1924 LEWIS, Sir Thomas (1881 – 1945); GRANT, Ronald Thomson (1892 – 1989)

Vascular reactions of the skin to injury. II. The liberation of a histamine-like substance in injured skin; the underlying cause of factitious urticaria and of wheals produced by burning; and observations upon the nervous control of certain skin reactions.

Lewis postulated that a histamine-like substance (“H-substance”) was responsible for the anaphylaxis symptom-complex. See also The blood-vessels of the human skin and their responses, 1927 (No. 797).

GMN 2602 · https://historyofmedicine.com/id/3024