The earliest surviving illustrated surgical codex was written and illuminated in Constantinople for the Byzantine physician Niketas (Nicetas) about 900 CE. It contains 30 full-page images illustrating the commentary of Apollonios of Kition on the Hippocratic treatise On Dislocations (Peri Arthron) and 63 smaller images scattered through the pages of the treatise on bandaging of Soranos of Ephesos. The Apollonian paintings represent various manipulations and apparatus employed in reducing dislocations; each of the images is framed in the Byzantine style in an archway of ornate design.
Apollonios of Kition's commentary on Hippocrates is the earliest surving commentary on any of the Hippocratic writings.
For more details about this manuscript see the entry at HistoryofInformation.com at this link.