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411 entries match Chemistry & Biochemistry [K01.900.200]
1978
#13986
Mutagenesis at a specific position in a DNA sequence.
Smith and Hutchison introduced site-directed mutagenesis, or oligonucleotide-directed mutagenesis, into molecular biology, resolving the problem of how to determine the effect of a single mutant gene with efficiency. …
1979
#6901
Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP.
Discovery of ubiquitin-mediated protein degradation. The paper is available at doi:10.1073/pnas.76.7.3107,PMC 383772, PMID 290989. See also Hershko, A.; Ciechanover, A.; Heller, H.; Haas, A.L.; Rose, I.A. (1980), "Pro…
1979
#14206
Experimental evidence in support of an extra-terrestrial trigger for the Cretaceous-Tertiary extinctions. (Abstract).
Iridium is a very rare element in the Earth's crust, but is found in anomalously high concentrations (around 1000 times greater than normal) in a thin worldwide layer of clay marking the boundary between the Cretaceou…
1980
#8175
Applications of artificial intelligence for organic chemistry: The Dendral project.
1980
#8794
The botany and chemistry of hallucinogens. By Richard Schultes and Albert Hofmann. With a forward by Heinrich Klüver. Revised and enlarged second edition.
1980
#14207
Extraterrestrial cause for the Cretaceous-Tertiary extinction.
Following up on No. 14206, the authors stated that the same excess iridium areas were found in two different areas of W. Europe and in New Zealand, and posited that “the anomalous iridium concentrations at the C [reta…
1981
#14183
Computer averaging of electron micrographs of the 405 ribosomal subunit.
Frank and colleagues developed a method that allows sorting of particle images into classes based on their orientation, as well as their structural features. Specifically Frank developed mathematical tools used for im…
1981
#14224
The crystallization of ribsomal proteins from the 50 S subunit of the Escherichia coli and Bacillus stearothermophilus ribosome.
The authors crystallized fragments of the 50S subunit of a thermophile bacterium’s ribosome to 3 angstroms resolution. Order of authorship in the original publication: Appelt, Dyck, et al., Yonath. Digital facsimile f…
1982
#1588.18
A bio-bibliography for the history of the biochemical sciences since 1800.
An index to bio-bibliographical articles listed alphabetically by scientist. Supplement published, Philadelphia, 1985.
1982
#11037
Origins of clinical chemistry: The evolution of protein analysis.
1982
#13932
Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena.
Discovery of ribozymes (ribonucleic acid enzymes). Cech discovered that RNA itself could cut strands of RNA, suggesting that life might have started as RNA. "In the 1970s, Cech had been studying the splicing of RNA in…
1983
#14140
Mammalian beta-adrenergic receptors. Structural differences in beta 1 and beta 2 subtypes revealed by peptide maps.
Lefkowitz and colleagues showed that there are two different types of beta receptors, distinguishing them as Beta-1 and Beta-2. They noticed that each has specific pharmacological characteristics. Order of authorship …
1985
#10785
Enzymatic amplication of B-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.
Polymerase chain reaction first published. With Randall K. Saiki, Stephen Scharf, Fred Faloona et al. Order of authorship in the original paper was Saiki, Scharf, Faloona, Mullis.... In 1993 the Nobel Prize in Chemist…
1985
#11060
Structure of the protein subunit in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3 Å resolution.
Discovery of the three-dimensional structure of a protein complex found in certain photosynthetic bacteria, called the photosynthetic reaction center. This was the first elucidation of the 3D crystal structure of any …
1985
#14339
Filamentous fusion phage: Novel expression vectors that display cloned antigens on the virion surface.
In this paper Smith invented "phage display technology," a technique where a specific protein sequence is artifically inserted into the coat protein gene of a bacteriophage, causing the protein to be expressed on the …
1987
#12997
Operation Everest II: Man at extreme altitude.
In 1985 Houston, Sutton and Cymerman and colleagues in Canada used a decompression chamber to simulate a seven week ascent of Mt. Everest. This appears to be their first paper summarizing the overall results. Many pub…
1990
#14340
Phage antibodies: Filamentous phage displaying antibody variable domains.
Working in the Laboratory of Molecular Biology at Cambridge University, Winter became interested in the idea that all antibodies have the same basic structure, with only small changes making them specific for one targ…
1991
#14208
Chicxulub Crater: A possible Cretaceous/Tertiary boundary impact crater on the Yucatán Peninsula, Mexico.
Eleven years after publication of No. 14207, Alan Hildebrand, working with Luis and Walter Alvarez, proposed that the Chicxulub Crater, discovered by Antonio-Camargo-Zanoguera and Glen T. Penfield during the 1970s, wa…
1992
#8773
A documentary history of biochemistry, 1770-1940. By Mikuláš Teich with Dorothy M. Needham.
1993
#14341
Tuning the activity of an enzyme for unusual environments: Sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide.
Arnold introduced a biochemical molecule manipulating technique to mimic the process of natural selection in creating new enzymes adapted to a specific catalytic reaction. She directed evolution of subtilisin E to obt…
1994
#8029
Afrikanische Arzneipflanzen und Jagdgifte.
Translated into English by Aileen Porter as African ethnobotany: Poisons and drugs. Chemistry - Pharmacology - Toxicology (Chapman & Hall, 1996).
1994
#11506
English manuscripts of Francis Glisson (1): from Anatomia hepatis (The anatomy of the liver), 1654. Cambridge Wellcome Texts and Documents, no. 3. Edited by Andrew Cunningham.
Publishes for the first time the surviving partial English text of Glisson's book on the liver, and of the work's postscript on the lymphatic system. Glisson wrote in English, but his text was translated into Latin fo…
1994
#13564
Green fluorescent protein as a marker for gene expression.
Chalfie and colleagues showed that the green fluorescent protein (GFP) from the jellyfish Aequorea victoria, could be used as a visible marker for protein localization and expression in vivo, in bacteria and worm cell…
1994
#14314
Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria.
Walker used X-ray crystallography to determine the structure of ATP synthase (ATPase or adenosine triphosphatase). In 1997 Walker shared the Nobel Prize in Chemistry with Paul Boyer and Jens C. Skou “for their elucida…
1995
#9572
Bibliotheca Lavoisieriana: The catalogue of the library of Antoine Laurent Lavoisier.
1995
#12430
Exploring the cell membrane: Conceptual developments. Edited by A. Kleinzeller. (Comprehensive biochemistry, Neuberger & van Deenen, eds., vol. 39).
1996
#12640
Collected works of Dorothy Crowfoot Hodgkin. Vol. I: Insulin. Vol. 2: Cholestrol, penicillin and other antibiotics. Vol. 3: General crystallography and essays. Edited by G. G. Dodson, J. P. Glusker, S. Ramaseshan and K. Venkatesan.
1996
#13565
Crystal structure of Aequorea victoria green fluorescent protein.
Tsien and colleagues published the crystal structure of the 238 A.A. long green fluorescent protein (GFP). With this data, the authors could determine what had to be modified within the protein in such a way that the …
1997
#8749
Moving questions: A history of membrane transport and bioenergetics.
"This book describes half a century of progress in two mainstream areas of biological research: membrane transport, initially a focus of physiologists, and oxidative phosphorylation, initially a focus of biochemists. …
1997
#12326
A devotion to their science: Pioneer women of radioactivity.
1998
#7780
High life: A history of high-altitude physiology and medicine.
1998
#14332
The structure of the potassium channel: Molecular basis of K+ conduction and selectivity.
The authors determined the first high resolution structure of an ion channel, called KcsA from the bacterium Streptomyces lividans. The structure that they revealed was perfectly adapted to allow entry of potassium io…
1999
#8752
Four centuries of clinical chemistry.
The first in-depth study of the development of this field that had such a profound impact on patient care beginning in the second half of the nineteenth century.
1999 –2000
#9573
The works of Robert Boyle. Edited by Michael Hunter and Edward B. Davis. 14 vols.
2000
#12133
Chemical biology. Selected papers of H. Gobind Khorana (with introductions).
Khorana edited this selection of his key papers and wrote the introductions to each paper.
2000
#13952
Structure of the 30S ribosomal subunit.
Ramakrishnan and colleagues determined the complete molecular structure of the 30S subunit of the ribosome and its complexes with several antibiotics. " The Abstract: "Genetic information encoded in messenger RNA is t…
2000
#13953
The structural basis of ribosome activity in peptide bond synthesis.
With Poul Nissen, Jeffrey Hansen, Nenad Ban, Peter B. Moore. Steitz shared the 2009 Nobel Prize in Chemistry with Venkatraman Ramakrishnan and Ada Yonath "for studies of the structure and function of the ribosome."
2000
#13982
Architecture of RNA polymerase II and implications for the transcription mechanism.
Kornberg devoted two decades to the development of methods to visualize the atomic structure of RNA polymerase and its associated protein components. Initially, Kornberg took advantage of expertise with lipid membrane…
2000
#14293
Cell surface engineering by a modified Staudinger reaction.
In 2022 Carolyn Bertozzi shared the Nobel Prize in Chemistry with Barry Sharpless and Morten Meldal for discovery of click chemistry. Bertozzi invented a biorthogonal variation of Sharpless and Meldal reactions. In th…
2001
#12890
Linus Pauling: Selected scientific papers. Vol. 1: Physical sciences. Vol. 2: Biomolecular sciences. Edited by Barclay Kamb, Linda Pauling Kamb, Peter Jeffress Pauling, Alexander Kamb, Linus Pauling, Jr.
2001
#14291
Click chemistry: Diverse chemical function from a few good reactions.
In 2022 Barry Sharpless shared the Nobel Prize in Chemistry with Carolyn Bertozzi and Morten Meldal for "the discovery of click chemistry." "Barry Sharpless coined the concept of click chemistry, where molecular build…
2002
#13768
Healing earths: The third leg of medicine. A history of minerals in medicine.
2002
#14292
Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides.
In 2022 Morten Meldal shared the Nobel Prize in Chemistry with Carolyn Bertozzi and Barry Sharpless for the discovery of click chemistry. Simultaneously, but independently of Sharpless, the authors discovered that cop…
2002
#14333
Crystal structure and mechanism of a calcium gated potassium channel.
The authors first obtained the crystal structure of a Ca2+ - gated K+ ion channel and then deciphered how ion channels open and close, a process called "gating" in response to cues in their environment. They determine…
2003
#12195
Human survival: Life and death in extreme environments.
2003
#14300
Design of a novel globular protein fold with atomic-level accuracy.
Called, "the breakthrough in computational de novo protein design." This was the proof of concept paper that computers and AI could be used to predict protein structures accurately and much faster than with convention…
2005
#10270
Theophrast und Galen – Celsus und Paracelsus. Medizin, Naturphilosophie und Kirchenreform im Basler Buchdruck bis zum Dreissigjährigen Krieg. Publikationen der Universitätsbibliothek, Nr. 36. 4 vols. plus index vol.
"The project began as a exhibition in the Basle University Library to commemorate the major anniversaries of the birth and death of Paracelsus (1493–1541). Not only did he work and teach in Basle, but many of his writ…
2005
#11193
Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: A double blind randomized placebo-controlled trial.
Order of authorship in the original paper: Taylor, Makunde, McGarry.... The authors treated infection by the parasitic worm Wuchereria bancrofti, cause of elephantiasis (lymphatic filariasis), by killing the Wolbachia…
2005
#13769
Essentials of medical geology: Impacts of the natural environment on public health. Editor-in-chief: Olle Selinus.
"... emphasizes the importance and interrelationships of geological processes to the health and diseases of humans and animals. Its accessible format fosters better communication between the health and geoscience comm…
2006
#11227