An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: December 10, 2024

Permanent Link for Entry #16498

  • 14183

Computer averaging of electron micrographs of the 405 ribosomal subunit.

Science, 214, 1353-1355, 1981.

Frank and colleagues developed a method that allows sorting of particle images into classes based on their orientation, as well as their structural features. Specifically Frank developed mathematical tools used for image analysis, which form the basis for single particle cryo-EM. He gathered them together in a suite of computer programs called “SPIDER”, making them readily available and useable for the scientific community. Order of authorship in the original publication: Frank, Verschoor, Boublik.

In 2017 Frank shared the Nobel Prize in Chemistry with Jacques Dubochet and Richard Henderson "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution."

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Structure, Microscopy › Cryogenic electron microscopy, NOBEL PRIZES › Nobel Prize in Chemistry (selected)
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