An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: December 10, 2024

Permanent Link for Entry #15803

  • 13526

Quantitative studies of tissue transplantation immunity. IV. Induction of tolerance in newborn mice and studies on the phenomenon of Runt Disease.

Phil. Trans. B., 242, 439-477, 1959.

First description of what became known as Graft-versus-host disease (GvDH). This the authors initially called "graft against host (GAH)." The authors cited three conditions, later known as the Billingham criteria, which must be met for GvHD to occur:

  • 'An immuno-competent graft is administered, with viable and functional immune cells.
  • The recipient is immunologically different from the donor – histo-incompatible.
  • The recipient is immunocompromised and therefore cannot destroy or inactivate the transplanted cells." (Wikipedia article on Graft-versus-host-disease, accessed 8-2021).
(Thanks to Juan Weiss for this reference and its interpretation.)


Subjects: IMMUNOLOGY, TRANSPLANTATION
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