An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: December 10, 2024

Permanent Link for Entry #16595

  • 14273

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.

Science, 292, 464-468, 2001.

Kaelin and colleagues identified aspects of the molecular machinery in Von Hippel-Landau disease that regulates the activity of genes in response to varying levels of oxygen.

In 2019 Kaelin shared the Nobel Prize in Physiology or Medicine with Sir Peter J. Ratcliffe and Gregg L. Semenza "for their discoveries of how cells sense and adapt to oxygen availability."

See also: Jaakkola, P., Mole, D., Tian, Y., Wilson, M., Gielbert, J., Gaskell, S., Kriegsheim, A., Hebestreit, H., Mukherji, M., Schofield, C., Maxwell, P., Pugh, C. & Ratcliffe, P. 2001. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science, 292, 468–72.

Ratcliffe and colleagues made essentially the same discovery simultaneously with Kaelin and colleagues.



Subjects: NOBEL PRIZES › Nobel Prize in Physiology or Medicine , PHYSIOLOGY › Physiology
Permalink: historyofmedicine.com/id/16595