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Browse across eight MeSH (opens in new tab) facets — era, geography, science, specialty, technology, history, culture, and reference. Select one tag per group; counts update across the others. What’s new in facet browse how facets relate to subjects and MeSH.
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924 entries match Physiology & Embryology [G07 / G02.149]
1989
#11198
A bibliography of the writings of Dr. William Harvey 1578-1657. Third edition, revised by Gweneth Whitteridge and Christine English.
This is the definitive edition of a bibliography first published by Sir Geoffrey Keynes in 1928 on the three hundredth anniversary of De motu cordis, and revised by him for a second edition in 1953. It contains a new …
1989
#12653
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome.
In this paper Houghton and colleagues named “hepatitis C” for the first time. They cloned and isolated the viral RNA genome and demonstrated that a patient who had high antibodies to a ‘native/wild strain’, reacted sp…
1989
#13245
Führer durch die Schausammlung Phonetisches Institut
1991
#10767
A conceptual history of modern embryology. Edited by Scott F. Gilbert. Developmental biology: A comprehensive synthesis, vol. 7.
1991
#13930
A novel multigene family may encode odorant receptors: A molecular basis for odor recognition.
"In their landmark paper published in 1991, Buck and Axel cloned olfactory receptors, showing that they belong to the family of G protein coupled receptors. By analyzing rat DNA, they estimated that there were approxi…
1992
#10671
A history of gastric secretion and digestion: Experimental studies to 1975.
1992
#11555
Mechanisierung des Herzen: Harvey und Descartes- Der Vitale und der mechanische Aspekt des Kreislaufs.
Translated into English by Marjorie Grene as The mechanization of the heart: Harvey and Descartes. Rochester, NY: University of Rochester Press, 2001.
1992
#14268
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
Honjo discovered the programmed cell death protein 1 (PD-1). This discovery significantly contributed to the establishment of cancer immunotherapy principle by PD-1 blockade. Order of authorship in the original public…
1993
#14010
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.
Ambros and colleagues discovered the first known microRNA (miRNA), a small single-stranded non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA sil…
1993
#14301
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans.
The authors cloned and generated the sequence of the lin-14 gene. They discovered that a segment in lin-14 mRNA (messenger RNA), was necessary for its inhibition by lin-4. Ruvkun and Ambros (No. 14010) then compared r…
1994
#9890
The physical and the moral: Anthropology, physiology, and philosophical medicine in France, 1750-1850.
1994
#11177
The embryonic human brain: An atlas of developmental stages.
"The first work devoted to the staged, embryonic human brain."
1994
#12638
Reader in the history of aphasia from [Franz] Gall to [Norman] Geschwind. Edited by Paul Eling.
1994
#14261
Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization.
Order of authorship in the original publication: Baba, M., Takeshige, Baba, N., Ohsumi. In 2016 Oshuni received the Nobel Prize in Physiology or Medicine "for his discoveries of mechanisms for autophagy."
1995
#14269
Purification and characterization of hypoxia-indicible factor 1.
Semenza and postdoctoral fellow Guang Wang discovered transcription factor HIF-1, a transcription factor that responds to decreases in available oxygen in the cellular environment, or hypoxia. IN 2019 Semenza shared t…
1996
#1588.4
The human brain and spinal cord: A historical study illustrated by writings from antiquity to the twentieth century. Second edition, revised and enlarged with a new preface by Edwin Clarke.
Massive anthology of primary source material on neuroanatomy and neurophysiology. Excellent commentaries and bibliographies. First edition, 1968.
1996
#7779
Respiratory physiology: People and ideas, edited by John B. West.
1996
#11183
Historic Embryology Papers.
https://embryology.med.unsw.edu.au/embryology/index.php/Historic_Embryology_Papers#Introduction "Introduction The linked papers are intended to give some historic background to Embryology. Historically, say pre-20th c…
1996
#14252
Toward a molecular definition of long-term memory storage.
"Abstract: The storage of long-term memory is associated with a cellular program of gene expression, altered protein synthesis, and the growth of new synaptic connections. Recent studies of a variety of memory process…
1996
#14267
Enhancement of antitumor immunity by CTLA-4 blockade.
In the early 1990s James Allison showed that CTLA-4 acts as an inhibitory molecule to restrict T-cell responses. In 1996, Allison was the first to show that antibody blockade of a T-cell inhibitory molecule (known as …
1997
#7457
Viable offspring derived from fetal and adult mammalian cells.
Cloning of the lamb Dolly, the first mammal to be cloned from an adult cell. Her birth established that the nuclei of at least some adult cells can be used to produce sheep or other animals that are genetically identi…
1997
#8749
Moving questions: A history of membrane transport and bioenergetics.
"This book describes half a century of progress in two mainstream areas of biological research: membrane transport, initially a focus of physiologists, and oxidative phosphorylation, initially a focus of biochemists. …
1997
#13229
The noblest animate motion: Speech, physiology and medicine in pre-Cartesian linguistic thought.
1997
#13541
Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA.
Rice and colleagues constructed a viral RNA genome with the 3’ region and a consensus region to exclude potential inactivating mutations, which was then injected into the liver of chimps. That RNA, specifically encode…
1997
#14274
The capsaicin receptor: a heat-activated ion channel in the pain pathway.
"Abstract: Capsaicin, the main pungent ingredient in ‘hot’ chilli peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central ner…
1998
#7780
High life: A history of high-altitude physiology and medicine.
1998
#12112
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in the Tlr4 gene.
Order of authorship in the original paper: Poltorak, Smirnova...Beutler. The authors, led by Beutler, showed that mice that harbor a mutation of the gene which codes for the production of the Toll-like receptor TLR4 q…
1998
#13286
Embryonic stem cell lines derived from human blastocysts.
Thomson and collaborators first isolated embryonic stem cells from human blastocysts. Order of authorship in original publication: Thomson, Itskovitz-Eldor, Shapiro et al. Available online from science.sciencemag.org …
1998
#13957
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.
The authors reported that tiny snippets of double-stranded RNA (dsRNA) effectively shut down specific genes, driving the destruction of messenger RNA (mRNA) with sequences matching the dsRNA. As a result, the mRNA can…
1998
#14251
DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission.
"Greengard's research focused on events inside the neuron caused by neurotransmitters. Specifically, Greengard and his fellow researchers studied the behavior of second messenger cascades that transform the docking of…
1999
#14262
A pdf Neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila.
In 2017 Hall shared the Nobel Prize in Physiology or Medicine with Michael Rosbash and Michael W. Young “for their discoveries of molecular mechanisms controlling the circadian rhythm.” Order of authorship in the orig…
1999
#14270
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
The focus of both Peter Ratcliffe’s and William Kaelin’s work, for which they shared the Nobel Prize with Gregg Semenza, was the relationship between pVHL and HIF. This led to an increased understanding of how cells s…
2001
#8748
Mechanisms of synaptic transmission: Bridging the gaps (1890-1990).
"Synaptic transmission plays a central role in the nervous system as the mechanism that allows for chemical and electrical communication between cells and thus connects discrete elements into the functioning whole. Th…
2001 –2011
#13227
A History of Speech - Language Pathology.
https://www.acsu.buffalo.edu/~duchan/new_history/overview.html "Organization of the website "The website is divided into six historical periods: History of the ancients: 3000 BC to 500 AD Middle ages: 400 to 1500 AD E…
2001
#14273
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
Kaelin and colleagues identified aspects of the molecular machinery in Von Hippel-Landau disease that regulates the activity of genes in response to varying levels of oxygen. In 2019 Kaelin shared the Nobel Prize in P…
2002
#7673
Embryos in wax: Models from the Ziegler studio.
2002
#13461
Origins of neuroscience: A history of explorations into brain function.
2003
#12195
Human survival: Life and death in extreme environments.
2004
#14205
Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst.
The authors in Korea, led by Woo-suk Hwang, reported the cloning of a human blastocyst using somatic cell nuclear transfer, and deriving pluripotent embryonic stem cells from that cloned blastocyst. In doing so they c…
2005
#9945
Hirnströme: Eine Kulturgeschichte der Elektroenzephalographie.
Translated into English by Ann M. Hentschel as Brainwaves: A cultural history of electroencephalography. Abingdon, Oxford and New York: Routledge, 2018.
2005
#10593
Profiles in cardiac pacing and electrophysiology.
2005
#12556
The embryo: Scientific discovery and medical ethics. Edited by Shraga Blazer and Etan Z. Zimmer.
Addresses 1: The beginning of life, 2: Embryonic stem cells, 3: Societal, ethical and religious views on genetic intervention in humans, 4: Genetics-From in vitro to in vivo, 5: Fetal surgical and pharmacological inte…
2005
#13622
Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA.
Karikó and Weissman discovered the nucleoside modifications that suppress the immungenicity of RNA, leading to their patents for the application of non-immunogenic, nucleoside-modified RNA (modRNA). This technology wa…
2005
#14257
Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release.
Südhof is credited with discovering much of the machinery mediating neurotransmitter release and presynaptic plasticity, beginning with the discovery of symaptotagmins and their role in neurostrasmitter release from t…
2005
#14259
Microstructure of a spatial map in the entorhinal cortex.
May-Britt Moser and Edvard Moser and colleagues discovered grid cells, specialized types of neurons that respond to specific locations in space. They are main components of the brain's GPS. Order of authorship in the …
2006
#8656
A most amazing scene of wonders: Electricity and enlightenment in early America.
"By examining the lives and visions of natural philosophers, spectacular showmen, religious preachers and medical therapists, he shows how electrical experiences of wonder, terror, and awe were connected to a broad ar…
2006
#8780
The great starvation experiment: Ancel Keys and the men who starved for science.
2006
#13287
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
Takahashi and Yamanaka reprogrammed mice fibroblast cells, which can produce only other fibroblast cells, to become pluripotent stem cells, which have the capacity to produce many different types of cells. This they a…
2008
#8308
Embodiments of will: Anatomical and physiological theories of voluntary animal motion from Greek antiquity to the Latin Middle Ages, 400 B.C - A.D.1300.
2008
#10550
Making visible embryos.
http://www.sites.hps.cam.ac.uk/visibleembryos/index.html "IMAGES OF HUMAN EMBRYOS Images of human embryos are everywhere. We see them in newspapers, clinics, classrooms, laboratories, family albums and on the internet…