An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: December 10, 2024

Permanent Link for Entry #15553

  • 13287

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Cell, 126, 663-676, 2006.

Takahashi and Yamanaka reprogrammed mice fibroblast cells, which can produce only other fibroblast cells, to become pluripotent stem cells, which have the capacity to produce many different types of cells. This they achieved by altering the expression of four genes. Full text available from Cell.com at this link.  See also No. 14063.

In 2012 Yamanaka shared the Nobel Prize in Physiology or Medicine with Sir John B. Gurdon "for the discovery that mature cells can be reprogrammed to become pluripotent."



Subjects: BIOLOGY › Cell Biology, EMBRYOLOGY, NOBEL PRIZES › Nobel Prize in Physiology or Medicine , Regenerative Medicine
Permalink: historyofmedicine.com/id/15553