An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: December 10, 2024

Permanent Link for Entry #15782

  • 13507

Efficacy and safety of the mRNA-1273 SARSCov-2 vaccine.

New Eng. J. Med., 384, 403-416, 2021.

mRNA-1273 is synonymous with the Moderna mRNA Covid-19 vaccine. The Moderna mRNA vaccine was produced from theoretical design to finished product and distribution in less than one year. This was the first published paper on that vaccine. It was first posted online on 12-30-20, updated on 1-15-21, and published in print on 2-4-2021. The vaccine was initially administered under "emergency use authorization" granted by the U.S. FDA.

This vaccine delivers the mRNA needed to code for the pre-fusion stabilized S (spike) protein to the inside of the host cell inside an encapsulating hollow lipid nanoparticle. That mRNA then instructs the host cell to produce S protein molecules which are then ferried out of the host cell and act as the antigen/immunogen for this vaccine once outside of the cell.

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: EPIDEMIOLOGY › Pandemics › COVID-19, IMMUNOLOGY › Immunization, IMMUNOLOGY › Vaccines, INFECTIOUS DISEASE › SARS CoV-2 (Cause of COVID-19), Nanotechnology in Medicine, VIROLOGY › Molecular Virology, VIROLOGY › VIRUSES (by Family) › Coronaviruses (Coronaviridae) › SARS CoV-2 (Cause of COVID-19)
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