1910 CARREL, Alexis (1873 – 1944); BURROWS, Montrose Thomas (1884 – 1947)
Cultures de sarcome en dehors de l’organisme.
Using the Rous chicken sarcoma, Carrel and Burrows were the first to grow tumor tissue in vitro.
GMN 2636 · https://historyofmedicine.com/id/3234
1910 ROUS, Francis Peyton (1879 – 1970)
A transmissible avian neoplasm (sarcoma of the common fowl).
Original description of the chicken sarcoma (Rous sarcoma). Rous demonstrated that sarcomatous tumors in hens could be transmitted to normal hens by the injection of cell-free filtrates (virus) of the original tumor. …
GMN 2637 · https://historyofmedicine.com/id/3238
1925 GYE, William Ewart (1884 – 1952)
The aetiology of malignant new growths.
Gye advanced the theory that an ultramicroscopic virus combined with an intrinsic chemical factor were concerned in the production of the Rous sarcoma.
GMN 2647 · https://historyofmedicine.com/id/3291
1970 TEMIN, Howard Martin (1934 – 1994); MIZUTANI, Satoshi
RNA-dependent DNA polymerase in virions of Rous sarcoma virus.
Discovery of reverse transcriptase. "In 1969, Temin and a postdoctoral fellow, Satoshi Mizutani, began searching for the enzyme that was responsible for the phenomenon of viral RNA being transferred into proviral DNA.…
GMN 2660.23 · https://historyofmedicine.com/id/3432
1978 ZAMECNIK, Paul Charles (1912 – 2009); STEPHENSON, Mary Louise (1921 – 2009)
Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide (tridecamer deoxyribonucleotide/hybridization competitor/hybridon).
Zamecnick and Stephenson reported the first example of specific inhibition of gene expression by an oligonucleotide when they demonstrated that a short oligonucleotide inhibited Rous sarcoma virus replication in cell …
GMN 13969 · https://historyofmedicine.com/id/16271
