Cadwalader, an American pupil of Cheselden, left a classical account of lead colic and lead palsy. This was later shown by Benjamin Franklin, printer of the above work, to be due to the consumption of Jamaica rum which had been distilled through lead pipes. The “extraordinary case” mentioned in the title refers to a case of osteomalacia. Cadwalader’s autopsy of the victim’s body is one of the earliest recorded in the United States. The above work is probably the first medical book containing significant original research to be published by an American physician in America. Digital facsimile from the National Library of Medicine, Internet Archive, at this link.