Addison was the first to draw attention to the importance of the adrenals in clinical medicine. The above work first appeared in the Lond. med. Gaz., 1849, 43, 517-18, and was later expanded into book form. It described the conditions, which later became known as “Addison’s disease” and pernicious anemia, which was later renamed “Addisonian anemia” by Trousseau. Text reprinted in Med. Classics, 1937, 2, 244-77. Facsimile edition, London, Dawson, 1968.