1974 COHEN, Stanley Norman (1935 – ); CHANG, Annie C.Y. (1936 – )

Genome construction between bacterial species in vitro: Replication and expression of staphylococcus plasmid genes in Escherichia coli.

Creation of the first transgenic organism: expression of Staphylococcus aureus genes in Escherichia coli. Digital facsimile from pnas.org at this link.

GMN 10047 · https://historyofmedicine.com/id/12236

1982 CHILTON, Mary-Dell (1939 – ); TEMPÉ, Jacques; TEPFER, David A.; ET AL

Agrobacterium rhizogenes inserts T-DNA into the genomes of the host plant root cells.

Chilton was the first (1977) to demonstrate the presence of a fragment of Agrobacterium Ti plasmid DNA in the nuclear DNA of crown gall tissue. Her research on Agrobacterium also showed that the genes responsible for …

GMN 14018 · https://historyofmedicine.com/id/16325

1983 BRINSTER, Ralph Lawrence (1932 – ); PALMITER, Richard (1942 – )

Metallothionein - human GH fusion genes stimulate growth of mice.

Brinster and Palmiter created the first "transgenic" animals, transferring non-native genes into mice through genetic engineering techniques. The cover of the issue of Science magazine in which this paper was publishe…

GMN 13975 · https://historyofmedicine.com/id/16278