2000 KORNBERG, Roger David (1947 – )
Architecture of RNA polymerase II and implications for the transcription mechanism.
Kornberg devoted two decades to the development of methods to visualize the atomic structure of RNA polymerase and its associated protein components. Initially, Kornberg took advantage of expertise with lipid membrane…
GMN 13982 · https://historyofmedicine.com/id/16285
2000 BERTOZZI, Carolyn Ruth (1966 – ); SAXON, Eliana
Cell surface engineering by a modified Staudinger reaction.
In 2022 Carolyn Bertozzi shared the Nobel Prize in Chemistry with Barry Sharpless and Morten Meldal for discovery of click chemistry. Bertozzi invented a biorthogonal variation of Sharpless and Meldal reactions. In th…
GMN 14293 · https://historyofmedicine.com/id/16616
2001 SHARPLESS, Karl Barry (1941 – ); KOLB, Hartmuth C. (1964 – ); FINN, M. G. (1958 – )
Click chemistry: Diverse chemical function from a few good reactions.
In 2022 Barry Sharpless shared the Nobel Prize in Chemistry with Carolyn Bertozzi and Morten Meldal for "the discovery of click chemistry." "Barry Sharpless coined the concept of click chemistry, where molecular build…
GMN 14291 · https://historyofmedicine.com/id/16614
2002 MELDAL, Morten Peter (1954 – ); TORNOE, Christian Wenzel; CHRISTENSEN, Christian A.
Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides.
In 2022 Morten Meldal shared the Nobel Prize in Chemistry with Carolyn Bertozzi and Barry Sharpless for the discovery of click chemistry. Simultaneously, but independently of Sharpless, the authors discovered that cop…
GMN 14292 · https://historyofmedicine.com/id/16615
2002 MACKINNON, Roderick (1956 – ); JIANG, Youxing; LEE, Alice; CHEN, Jiayun; ET AL
Crystal structure and mechanism of a calcium gated potassium channel.
The authors first obtained the crystal structure of a Ca2+ - gated K+ ion channel and then deciphered how ion channels open and close, a process called "gating" in response to cues in their environment. They determine…
GMN 14333 · https://historyofmedicine.com/id/16658
2003 BAKER, David (1962 – ); KUHLMAN, Brian A.; DANTAS, Gautam; IRETON, Gregory C.; VARANI, Gabriele; ET AL
Design of a novel globular protein fold with atomic-level accuracy.
Called, "the breakthrough in computational de novo protein design." This was the proof of concept paper that computers and AI could be used to predict protein structures accurately and much faster than with convention…
GMN 14300 · https://historyofmedicine.com/id/16625
2011 RASMUSSEN, Søren G. F.; DEVREE, Brian T.; KOBILKA, Brian Kent (1955 – ); ET AL
Crystal structure of the β2 adrenergic receptor–Gs protein complex.
Kobilka and colleagues published the crystal structure of a beta-2 receptor forming a complex with the G protein coupled receptor. This was the first time that a complete complex of an active receptor and it's Gs prot…
GMN 14134 · https://historyofmedicine.com/id/16445
2012 DOUDNA, Jennifer Anne (1964 – ); CHARPENTIER, Emmanuelle (1968 – ); JINEK, Martin; CHYLINSKI, Krzysztof; FONFARA, Ines; HAUER, Michael
A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity.
Order of authorship in the original publication: Jinek, Chylinski, Fonfar, Hauer, Doudna, Charpentier. Doudna, Charpentier and colleagues showed for the first time that the CRISPR evolutionary immune tool of bacteria …
GMN 11844 · https://historyofmedicine.com/id/14048
2021 EVANS, Richard; JUMPER, John; HASSABIS, Demis (1976 – ); ET AL
Highly accurate protein structure prediction with AlphaFold.
Abstract: "Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function. Through an enormous experimental effort1,2,3,4, the structures of around 100,0…
GMN 14026 · https://historyofmedicine.com/id/16333
