1918 ZONDEK, Hermann (1887 – 1979)
Das Myxödemherz
First systematic study of the characteristic changes of the heart in myxedema.
GMN 3849 · https://historyofmedicine.com/id/4880
1919 DUNHILL, Sir Thomas Peel (1876 – 1957)
Some considerations on the operation for exophthalmic goitre.
Dunhill’s operation of exophthalmic goitre is described above. He was a pioneer in thyroid surgery.
GMN 3849.1 · https://historyofmedicine.com/id/4881
1919 –1920 GOETSCH, Emil (1883 – 1963)
Epinephrin hypersensitiveness test in the diagnosis of hyperthyroidism.
Goetsch devised a skin reaction test for use in the diagnosis of hyperthyroidism
GMN 3850 · https://historyofmedicine.com/id/4883
1923 HUNT, Reid (1870 – 1948)
The acetonitril test for thyroid and of some alterations of metabolism.
The acetonitril test was introduced by Hunt in 1905 (J. biol. Chem., 1, 33) and later modified by him. It shows the activity of thyroid preparations to be proportional to their iodine content.
GMN 1134 · https://historyofmedicine.com/id/1320
1923 HANSON, Adolph Melanchton (1888 – 1959)
An elementary chemical study of the parathyroid glands of cattle.
Hanson isolated the first really potent parathyroid extract.
GMN 1135 · https://historyofmedicine.com/id/1322
1924 BOOTHBY, Walter Meredith (1880 – 1953); PLUMMER, Henry Stanley (1874 – 1937)
The value of iodine in exophthalmic goitre.
Plummer and Boothby recommended the pre-operative administration of iodine in exophthalmic goitre.
GMN 3851 · https://historyofmedicine.com/id/4885
1926 HARINGTON, Sir Charles Robert (1897 – 1972)
Chemistry of thyroxine I.
Harington showed that thyroxine is a derivative of tyrosine, and he gave its formula as C15H11O4NI4.
GMN 1137 · https://historyofmedicine.com/id/1329
1932 JOLL, Cecil Augustus (1885 – 1945)
Diseases of the thyroid gland, with special reference to thyrotoxicosis.
Second edition, 1951. Joll was a pioneer in the treatment of thyrotoxicosis by means of subtotal thyroidectomy.
GMN 3852 · https://historyofmedicine.com/id/4887
1933 BLUMGART, Hermann Ludwig (1895 – 1977); LEVINE, Samuel Albert (1891 – 1966); ET AL
Congestive heart failure and angina pectoris: The therapeutic effect of thyroidectomy on patients without clinical or pathologic evidence of thyroid toxicity.
Thyroidectomy for congestive heart failure and angina pectoris. With D. D. Berlin.
GMN 2899 · https://historyofmedicine.com/id/4387
1942 HERTZ, Saul (1905 – 1950); ROBERTS, A
Application of radioactive iodine in therapy of Graves’s disease.
GMN 3853 · https://historyofmedicine.com/id/4889
1943 ASTWOOD, Edwin Bennett (1909 – 1976)
Treatment of hyperthyroidism with thiourea and thiouracil.
Astwood was the first to treat human cases of hyperthyroidism with thiourea and thiouracil.
GMN 3854 · https://historyofmedicine.com/id/4891
1945 ASTWOOD, Edwin Bennett (1909 – 1976)
Some observations on the use of thiobarbital as an antithyroid agent in the treatment of Graves’s disease.
Clinical introduction of thiobarbital.
GMN 3855 · https://historyofmedicine.com/id/4893
1946 SEIDLIN, Samuel M. (1895 – 1955); MARINELLI, Leonidas D. (1906 – 1974); OSHRY, Eleanor
Radioactive iodine therapy: Effect on functioning metastases of adenocarcinoma of the thyroid.
Seidlin and Marinelli described the first successful treatment of a patient with thyroid cancer metastases using radioiodine (I-131). This paper demonstrated the potential of nuclear medicine as a medical specialty.
GMN 9338 · https://historyofmedicine.com/id/11520
1949 JONES, Reuben G.
Imidazoles. IV. The synthesis and antithyroid activity of some 1-substituted-2-mercaptoimidazoles.
Synthesis of methimazole (mercazole, thiamazole), an antithyroid drug more potent than methylthiouracil. With E. C. Kornfeld, K. C. McLaughlin, and R. C. Anderson.
GMN 3855.1 · https://historyofmedicine.com/id/4894
1951 LAWSON, Alexander
Antithyroid activity of 2-carbethoxythio-1-methylglyoxaline.
Synthesis of Carbimazole. With C. Rimington and C. E. Searle. For clinical application see Lancet, 1951, 2, 621.
GMN 3855.2 · https://historyofmedicine.com/id/4896
1953 GROSS, Jack (1921 – 1994); PITT-RIVERS, Rosalind Venetia Lane Fox (1907 – 1990)
3:5:3'-Triiodothyronine. I. Isolation from thyroid gland and synthesis.
Discovery of the second thyroid hormone, triiodothyronine. Digital facsimile from PubMedCentral at this link.
GMN 1138.1 · https://historyofmedicine.com/id/1350
1956 ROITT, Ivan Maurice (1927 – ); DONIACH, Deborah (1912 – 2004); ET AL
Autoantibodies in Hashimoto’s disease (lymphadenoid goitre).
Demonstration of autoantibodies. With P. N. Campbell, and R. V. Hudson.
GMN 2578.19 · https://historyofmedicine.com/id/4226
1956 WITEBSKY, Ernest (1901 – 1969); ROSE, Noel Richard (1927 – 2020)
Studies on organ specificity. IV. Production of rabbit thyroid antibodies in the rabbit.
Autoimmune thyroiditis
GMN 2578.20 · https://historyofmedicine.com/id/4230
1957 WITEBSKY, Ernest (1901 – 1969); ROSE, Noel Richard (1927 – 2020); ET AL
Chronic thyroiditis and autoimmunization.
"Witebsky helped develop procedures for the isolation and partial characterization of A and B blood antigens. He also began the practice of neutralization of certain antibodies in the blood of universal blood donors. …
GMN 13471 · https://historyofmedicine.com/id/15745
1970 BURGUS, Roger Cecil (1934 – ); DUNN, Thomas F.; DESIDERIO, Dominic; GUILLEMIN, Roger (1924 – 2024)
Characterization of ovine hypothalamic hypophysiotropic TSH-releasing factor.
Working with sheep preparations, the authors determined that the molecular structure of TRF (thyroid releasing hormone), is 2-pyrrolidone-5-carboxylyl-histidyl-L-proline amide. On page 324, they showed the molecular s…
GMN 14232 · https://historyofmedicine.com/id/16550
