1922 COLLIP, James Bertram (1892 – 1965); BANTING, Sir Frederick Grant (1891 – 1941); BEST, Charles Herbert (1899 – 1978)
Pancreatic extracts in the treatment of diabetes mellitus.
The first clinical application of insulin in the treatment of diabetes. Co-authored by W. R. Campbell, and A. A. Fletcher. Digital facsimile from PubMedCentral at this link.
GMN 3968 · https://historyofmedicine.com/id/5257
1923 COLLIP, James Bertram (1892 – 1965)
The original method as used for the isolation of insulin in semipure form for the treatment of the first clinical cases.
Collip improved insulin.
GMN 3969 · https://historyofmedicine.com/id/5261
1924 BANTING, Sir Frederick Grant (1891 – 1941)
Insulin.
GMN 3970 · https://historyofmedicine.com/id/5269
1927 WILDER, Russell Morse (1885 – 1959); ET AL
Carcinoma of the islands of the pancreas; hyperinsulinism and hypoglycemia.
R. M. Wilder, F. N. Allan, M. H. Power, and H. E. Robertson reported the occurrence of carcinoma with hyperinsulinism. They also reported the first operation for hyperinsulinism performed on December 2, 1926 by Willia…
GMN 3972 · https://historyofmedicine.com/id/5280
1930 RUIZ, Celestino L. (1904 – ); ET AL
Contribución al estudio sobre la composición quimica de la insulina. Estudio de algunos cuerpos sintéticos solfurados con acción hypoglucemiante.
Discovery of the hypoglycemic effect of certain sulphonamide derivatives. With L. L. Silva and L. Libenson.
GMN 3973 · https://historyofmedicine.com/id/5284
1936 INGRAM, Walter Robinson (1905 – 1978); ET AL
Experimental diabetes insipidus in the monkey.
With C. Fisher and S. W. Ransom.
GMN 3905 · https://historyofmedicine.com/id/4981
1936 WILSON, Clifford (1906 – 1997); KIMMELSTIEL, Paul (1900 – 1970)
Intercapillary lesions in the glomeruli of the kidney.
“Kimmelstiel–Wilson syndrome”. First description of nodular intercapillary glomerulosclerosis, the only known morphological alteration specific, or almost so, for diabetes mellitus.
GMN 4250 · https://historyofmedicine.com/id/5138
1936 HAGEDORN, Hans Christian (1888 – 1971); ET AL
Protamine insulinate.
Hagedorn created NPH insulin and founded Nordisk Insulinlaboratorium, known today as Novo Nordisk. NPH insulin is one of the earliest examples of engineering drug delivery. Hagedorn became interested in modifying the …
GMN 3974 · https://historyofmedicine.com/id/5285
1936 KERR, Robert Bews (1908 – 1997); ET AL
Protamine insulin.
R. B. Kerr, C. H. Best, W. R. Campbell, and A. A. Fletcher advocated the combination of zinc with insulin to delay its absorption rate. Later this was combined with protamine to form protamine zinc insulin.
GMN 3975 · https://historyofmedicine.com/id/5288
1937 YOUNG, Sir Frank George (1908 – 1988)
Permanent experimental diabetes produced by pituitary (anterior lobe) injections.
Anterior pituitary diabetogenic hormone.
GMN 1173 · https://historyofmedicine.com/id/1576
1939 BIGGART, Sir John Henry (1905 – 1979); ALEXANDER, George Lionel (1902 – 1970)
Experimental diabetes insipidus.
Production of diabetes insipidus in dogs by injury to the hypothalamus.
GMN 3907 · https://historyofmedicine.com/id/4983
1939 WHITE, Priscilla (1900 – 1989); ET AL
Prediction and prevention of late pregnancy accidents in diabetes.
First report of hormone treatment. Written with R.S. Titus, E.P. Joslin, and H. Hunt.
GMN 6231 · https://historyofmedicine.com/id/7860
1944 LOUBATIÈRES, Auguste-Louis (1912 – 1977)
Analyse du mécanisme de l’action hypoglycémiante de p-aminobenzène-sulfamido-isopropylthiodiazol (2254 RP).
Loubatières initiated work on the hypoglycaemic sulphonamides. See his historical account in Ann. N.Y. Acad. Sci., 1957, 71, 4-11.
GMN 3976.1 · https://historyofmedicine.com/id/5292
1948 DOHAN, Francis Curtis (1907 – 1991); LUKENS, Francis Dring Wetherill (1899 – 1978)
Experimental diabetes produced by the administration of glucose.
Experimental diabetes produced by artificially-induced hyperglycemia.
GMN 3977 · https://historyofmedicine.com/id/5294
1951 HALLAS-MØLLER, Knud (1914 – 1984); ET AL
Kliniske undersøgelser med nye retarderet virkende insulin-praeparater.
First clinical trials of lente, ultralente, and semilente insulin zinc suspension. See also Science, 1952, 116, 394-98; and J. Amer. med. Assoc., 1952, 150, 1667. With M. Jersild, K. Peterson, and J. Schlichtkrull.
GMN 3978 · https://historyofmedicine.com/id/4756
1955 FRANKE, Hans (1909 – 1955); FUCHS, J.
Ein neues antidiabetisches Prinzip. Ergebnisse klinischer Untersuchungen.
Introduction of carbutamide (BZ55), the first of the sulphonylureas. It was followed by tolbutamide and chlorpropamide.
GMN 3978.1 · https://historyofmedicine.com/id/4761
1956 MASKE, Helmut (1921 – )
Über die orale Behandlung des Diabetes mellitus mit N-(4-Methyl-Benzolsulfonyl)-N’Butyl-Harnstoff (D 860).
A Symposium on tolbutamide, introduced by H. Maske.
GMN 3978.2 · https://historyofmedicine.com/id/4766
1957 UNGAR, Georges (1906 – 1977); ET AL
Pharmacological studies of a new oral hypoglycemic drug.
Phenformin, a biguanide formerly used in diabetes. With L. Freedman and S. L. Shapiro. Clinical report on pp. 193-4.
GMN 3978.3 · https://historyofmedicine.com/id/4770
1961 SCHUMACHER, Joseph (1902 – 1966)
Index zum Diabetes mellitus. Eine internationale Bibliographie.
GMN 3978.4 · https://historyofmedicine.com/id/4779
1962 WRENSHALL, Gerald Alfred
The story of insulin: Forty years of success against diabetes.
With G. Hetenyi and W. R. Feasby.
GMN 3978.5 · https://historyofmedicine.com/id/4783
1964 PAPASPYROS, Nikos S.
The history of diabetes mellitus. 2nd ed.
GMN 3979 · https://historyofmedicine.com/id/4788
1976 KOENIG, Ronald Jay; PETERSON, Charles M.; CERAMI, Anthony (1940 – ); ET AL
Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus.
The authors studied 5 diabetic patients and first realized that A1c was an ideal index to reveal the overall control of a patient’s blood sugar over the past several months before a doctor’s visit. They were the first…
GMN 14222 · https://historyofmedicine.com/id/16539
1979 GOEDDEL, David V. (1951 – ); KLEID, Dennis G.; CREA, Roberto; BOLÍVAR ZAPATA, Francisco Gonzalo (1948 – ); ET AL
Expression in Escherichia coli of chemically synthesized genes for human insulin (plasmid construction / lac operon / fused proteins / radioimmunoassay / peptide purification).
Working at Genentech, Kleid and Goeddel and colleagues were the first scientists to apply genetic engineering techniques, incorporating chemically synthesized DNA encoding human insulin into E. coli, that expressed, a…
GMN 13980 · https://historyofmedicine.com/id/16283
1982 BLISS, Michael John William (1941 – 2017)
The discovery of insulin.
GMN 3979.1 · https://historyofmedicine.com/id/4791
1987 PEUMERY, Jean-Jacques
Histoire illustrée du diabète de l’antiquité à nos jours.
GMN 3979.2 · https://historyofmedicine.com/id/4795
1989 ENGELHARDT, Dietrich von (1941 – )
Diabetes, its medical and cultural history: Outlines — texts — bibliography. Edited by Dietrich von Engelhardt.
GMN 9465 · https://historyofmedicine.com/id/11648
2009 FURDELL, Elizabeth Lane (1944 – )
Fatal thirst: Diabetes in Britain until insulin.
GMN 9817 · https://historyofmedicine.com/id/12005