Browse by Entry Number 14300–14399
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Design of a novel globular protein fold with atomic-level accuracy.Science, 302, 1364-1368, 2003.Called, "the breakthrough in computational de novo protein design." This was the proof of concept paper that computers and AI could be used to predict protein structures accurately and much faster than with conventional cryoEM or crystallography. In 2024 Baker shared half of the Nobel Prize in Chemistry with Demis Hassabis and John Jumper for "revealing protein's secrets through computing and artificial intelligence." Subjects: Artificial Intelligence in Medicine , BIOLOGY › MOLECULAR BIOLOGY › Protein Structure, NOBEL PRIZES › Nobel Prize in Chemistry |
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Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans.Cell, 75, 855-862, 1993.The authors cloned and generated the sequence of the lin-14 gene. They discovered that a Subjects: BIOLOGY › MOLECULAR BIOLOGY › Molecular Biology, NOBEL PRIZES › Nobel Prize in Physiology or Medicine |
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Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA.Nature, 408, 86-89, 2000.Working with the let-7 gene, the authors led by Ruvkun showed that microRNA encoded by the let-7 gene was highly conserved, and present throughout the animal kingdom, proving that gene regulation by microRNA is universal among unicellular organisms on Earth. This paper, published seven years after the initial discovery (No. 14301) provided the evidence to convince skeptics of the existence of microRNA. Subjects: BIOLOGY › MOLECULAR BIOLOGY › Molecular Biology |
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Oral maintenance therapy for cholera in adults.Lancet, 292, 370-372, 1968.Abstract: Subjects: EPIDEMIOLOGY › Pandemics › Cholera, INFECTIOUS DISEASE › Cholera, THERAPEUTICS › Oral Rehydration Therapy |
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Oral or nasogastric maintenance therapy in pediatric cholera patients.J. Pediat., 78, 355-358, 1971.Subjects: EPIDEMIOLOGY › Pandemics › Cholera, INFECTIOUS DISEASE › Cholera, PEDIATRICS, THERAPEUTICS › Oral Rehydration Therapy |
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The genetic control of tertiary protein structure studies with mode systems.Cold Spring Harbor Symposium in Quantitative Biology, 28, 439-449, 1963.In 1972 Anfinsen shared half of the Nobel Prize in Chemistry with Stanford Moore and William H. Stein for "for his work on ribonuclease, especially concerning the connection between the amino acid sequence and biologically active conformation." Anfinsen's discovery became known as Anfinsen's dogma. Subjects: BIOLOGY › MOLECULAR BIOLOGY › Molecular Biology, BIOLOGY › MOLECULAR BIOLOGY › Protein Structure, NOBEL PRIZES › Nobel Prize in Chemistry |
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The sequence of the amino acid residues in performic acid-oxidized ribonuclease.J. Bio. Chem., 235, 633-647, 1960.In 1959 Moore and Stein announced the first determination of the complete amino acid sequence of an enzyme, ribonuclease. Subjects: BIOLOGY › MOLECULAR BIOLOGY › Molecular Biology, NOBEL PRIZES › Nobel Prize in Chemistry |
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Corps du papier. L'Anatomie en papier mâché du Docteur Auzoux. Text: Christophe Degueurce. Photos: Didier Gaillard. Préface: Philippe Comar.Paris: Éditions de la Martinière, 2012.Outstanding color photographs. Subjects: ANATOMY › 19th Century |