An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15793 entries, 13706 authors and 1920 subjects. Updated: October 6, 2022

Browse by Entry Number 14000–14099

57 entries
  • 14000

Plaque formation and isolation of pure lines with poliomyelitis viruses.

J. Exp. Med., 99, 167-182, 1954.

Dulbecco and Vogt were the first to successfully grow the poliovirus in vitro. They were also able to plaque purify it-- an essential step for subsequent vaccine production.

Subjects: IMMUNOLOGY › Vaccines, VIROLOGY › VIRUSES (by Family) › Picornaviridae › Poliovirus
  • 14001

Structure of tobacco mosaic virus.

Nature, 175, 379-381, 1955.

The first discovery of the geometry of a protein structure. Franklin, whose X-ray photographs of DNA were crucial to Watson and Crick's discovery of the molecule's double helix structure in 1953, began researching the molecular structure of the tobacco mosaic virus (TMV) after moving from King's College to Birkbeck College in mid-1953. Between 1953 and her death in 1958, Franklin and her team of researchers made significant advances in knowledge of the virus's molecular structure, beginning with the present paper announcing her discovery, based on her X-ray photographs, that the rod-shaped TMV units are all the same length and that they are made up of identical protein subunits. Preceding Perutz and Kendrew's mapping of the structures of myoglobin and hemoglobin by several years, this was the first discovery of the geometry of a protein structure.

Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Structure, VIROLOGY › VIRUSES (by Family) › Virgaviridae › Tobacco Mosaic Virus
  • 14002

G[othofredi]. G[uillelmi]. L[eibnitii]. Relatio ad inclytam Societatem Leopoldinam Naturae Curiosorum, de novo antidysenterico Americano magnis successibus comprobato.

Hannover & Wolfenbütte: Gottfried Freytag, 1696.

This study of the ipecacuanha root and its effects as a emetic, nauseant, expectorant and dispahoretic, Leibniz issued on what he called "the new American antidysentery drug" after reading about the root in Piso and Marggraf's Historia naturalis Brasilia (1648). The report is considered Leibniz's most comprehensive contribution to medicine. The printer of the work, Freytag, issued it in three different ways: As an appendix to Freytag's edition of Martin Lister's Sex exercitationes medicales de quibusdam morbis chronicis (Frankfurt, 1696), and also in Freytag's early periodical, Miscellanea curiosa, sive Ephemeridum medico-physicarum Germanicarum (Nuremberg, 1696). From that publication a separate pamphlet, or an early journal offprint, was also issued.

Subjects: PHARMACOLOGY › PHARMACEUTICALS › Botanic Sources of Single Component Drugs › Ipecacuanha
  • 14003

Le bactériophage et son comportement.

Paris: Masson & Cie, 1926.

In this book d'Hérelle reported on the results of quantitative work based on the plaque-count, and dilution methods of assay that he invented. He described a three-step process for the life history of the bacteriophage virus: 1. Attachment to the susceptible bacterium, 2. Multiplication in the cell, 3. Disintegration of the cell to free the progreny virus particles and attachment of the progreny to other susceptible bacteria, if they are present.
English translation as The bacteriophage and its behavior. Baltimore: Williams & Wilkins Co., 1926. 

Subjects: VIROLOGY › Bacteriophage
  • 14004

The identification and characterization of bacteriophages with the electron microscope.

Proc. Nat. Acad. Sci. (USA) 28, 127-130., 1942.

First identification, observation under the electron microscope, and reproduction of photomicrographs of bacteriophages taken through the electron microscope.

Digital facsimile, but with poor reproductions of the two plates, from PubMedCentral at this link.

Subjects: IMAGING › Photography / Photomicrography , VIROLOGY › Bacteriophage
  • 14005

Electron microscope studies of bacterial viruses.

J. Bacteriol., 46, 57-76, 1943.

This work demonstrated the absorption of the phages on the host cell, and the lysis of the host cell and the liberation of a hundred or so daughter paritcles from each cell. It also showed that the particles multiply inside the cells rather than at their surfaces, since unti lysis occurs the number of particles visible at the surface remains constant. 
Digital facsimile from PubMedCentral at this link. For an extensive commentary on this paper, including correspondence between Anderson and Delbruck before and after publication see T. F. Anderson, "Electronic microscopy of phages," Phage and the origins of molecular biology. Expanded Edition, edited by John Cairns, Gunther Stent and James D. Watson (1992) 63-78.

Subjects: IMAGING › Photography / Photomicrography , VIROLOGY › Bacteriophage
  • 14006

Application of synchrotron radiation to protein crystallography: Preliminary results.

Proc. Nat. Acad. Sci. (USA), 73, 128-132, 1975.

First report on the application of synchrotron radiation to protein crystallography. Order of authorship in the original publication: Phillips, Wlodwawer..., Hodgson. Digital facsimile from at this link.

"Synchrotrons can now produce X-rays that are one trillion times brighter than the X-rays Rosalind Franklin used for Photo 51, according to University of Liverpool biophysicist Samar Hasnain, editor in chief of the Journal of Synchrotron Radiation and other journals of the International Union of Crystallography. Indeed, synchrotrons have vastly expanded the scope and refinement of investigations of biological structures and dynamics. They have enabled dazzling biological discoveries, including those associated with five Nobel Prizes in the past 20 years. The most recent of these were Brian Walker and Robert Lefkowitz's 2012 Nobel Prize in Chemistry for their work on G protein–coupled receptors, membrane proteins that send signals of extracellular molecules to the cell's interior, and Thomas Steitz, Venki Ramakrishnan, and Ada Yonath's 2009 Nobel Prize in Chemistry for their work on the structure of the ribosome, the cell's organelle for synthesizing proteins for many purposes. Walker and Lefkowitz's synchrotron work was primarily done at the Advanced Photon Source (APS) synchrotron at Argonne National Laboratory, in Illinois, and the Steitz, Ramakrishnan, and Yonath ribosome work involved research at multiple synchrotrons, including APS and the European Synchrotron Radiation Facility (ESRF), in Grenoble, France" (

Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Crystallization, BIOLOGY › MOLECULAR BIOLOGY › Protein Structure
  • 14007

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40 transformed cells and uninfected embryonal carcinoma cells.

Cell, 17, 43-52, 1979.

Levine discovered the tumor suppressor protein p53, also known as Tumor protein P53. Because it prevents cancer formation TP 53 is classified as a tumor suppressor gene. The discovery was completed in 1989 and recorded in the following paper: Cathy A. Finlay, Philip W. Hinds, and Arnold J. Levine, "The p53 proto-onogene can act as a suppressor of transformation," Cell, 57 (1989), 1083-1093.

  • 14008

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Cell, 72, 971-983, 1993.

Identification by the many scientists in The Huntington's Disease Collaborative Research Group, including Gusella, of the single defective gene on chromosome 4 that causes the progressive brain disorder, Huntington's disease. The defect is dominant, meaning that anyone who inherits it from a parent with Huntington's will eventually develop the disease. The defective gene codes for a protein called huntingtin. Since identification of the defective gene, a diagnostic genetic test has been developed that can detect the defective gene in people who do not yet have symptoms of the disease.

Subjects: GENETICS / HEREDITY › HEREDITARY / CONGENITAL DISEASES OR DISORDERS › Inherited Neurological Disorders › Huntington's Chorea
  • 14009

Unusual resistance to peptidyl transferase to protein extraction procedures.

Science, 256,1416-1419, 1992.

Noller demonstrated that the ribosome is a ribozyme, a critical step in understanding how ribosomes translate the genetic information in DNA into the language of proteins.

Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Synthesis
  • 14010

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.

Cell, 75, 843-854, 1993.

Ambros and colleagues discovered the first known microRNA (miRNA), a small single-stranded non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression. The human genome may encode over 1900 miRNAs, although more recent analysis suggests that the number is closer to 2,300.

The first human disease associated with deregulation of miRNAs was chronic lymphocytic leukemia. In this disorder, the miRNAs work as both tumor suppressors and oncogenes.

Order of authorship in the original publication: Lee, Feinbaum, Ambros.

Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Synthesis
  • 14011

A history of neuro-oncology.

Montréal: DW Consulting, 2008.

Subjects: NEUROLOGY › History of Neurology, NEUROSURGERY › History of Neurosurgery, NEUROSURGERY › Neuro-oncology
  • 14012

Sir William Osler's Leonardo da Vinci collection: Flight, anatomy and art.

Montréal: [Privately Printed], 2019.

Subjects: ANATOMY › 16th Century, ART & Medicine & Biology
  • 14013

A physics-based virtual simulator for cranial microneurosurgery training.

Operative Neurosurgery, 71, 32-42, 2012.



"A virtual reality neurosurgery simulator with haptic feedback may help in the training and assessment of technical skills requiring the use of tactile and visual cues.


"To develop a simulator for craniotomy-based procedures with haptic and graphics feedback for implementation by universities and hospitals in the neurosurgery training curriculum.


"NeuroTouch was developed by a team of more than 50 experts from the National Research Council Canada in collaboration with surgeons from more than 20 teaching hospitals across Canada. Its main components are a stereovision system, bimanual haptic tool manipulators, and a high-end computer. The simulation software engine runs 3 processes for computing graphics, haptics, and mechanics. Training tasks were built from magnetic resonance imaging scans of patients with brain tumors.


"Two training tasks were implemented for practicing skills with 3 different surgical tools. In the tumor-debulking task, the objective is complete tumor removal without removing normal tissue, using the regular surgical aspirator (suction) and the ultrasonic aspirator. The objective of the tumor cauterization task is to remove a vascularized tumor with an aspirator while controlling blood loss using bipolar electrocautery."

Subjects: COMPUTING/MATHEMATICS in Medicine & Biology › Computer Simulation, COMPUTING/MATHEMATICS in Medicine & Biology › Visualization, Education, Biomedical, & Biomedical Profession, NEUROSURGERY › Neuro-oncology
  • 14014

Machine learning identification of surgical and operative factors associated with surgical expertise in virtual reality simulation.

JAMA Network Open, 2 (8): e198363., 2019.

"Importance  Despite advances in the assessment of technical skills in surgery, a clear understanding of the composites of technical expertise is lacking. Surgical simulation allows for the quantitation of psychomotor skills, generating data sets that can be analyzed using machine learning algorithms.

"Objective  To identify surgical and operative factors selected by a machine learning algorithm to accurately classify participants by level of expertise in a virtual reality surgical procedure.

"Design, Setting, and Participants  Fifty participants from a single university were recruited between March 1, 2015, and May 31, 2016, to participate in a case series study at McGill University Neurosurgical Simulation and Artificial Intelligence Learning Centre. Data were collected at a single time point and no follow-up data were collected. Individuals were classified a priori as expert (neurosurgery staff), seniors (neurosurgical fellows and senior residents), juniors (neurosurgical junior residents), and medical students, all of whom participated in 250 simulated tumor resections.

"Exposures  All individuals participated in a virtual reality neurosurgical tumor resection scenario. Each scenario was repeated 5 times.

"Main Outcomes and Measures  Through an iterative process, performance metrics associated with instrument movement and force, resection of tissues, and bleeding generated from the raw simulator data output were selected by K-nearest neighbor, naive Bayes, discriminant analysis, and support vector machine algorithms to most accurately determine group membership.

"Results  A total of 50 individuals (9 women and 41 men; mean [SD] age, 33.6 [9.5] years; 14 neurosurgeons, 4 fellows, 10 senior residents, 10 junior residents, and 12 medical students) participated. Neurosurgeons were in practice between 1 and 25 years, with 9 (64%) involving a predominantly cranial practice. The K-nearest neighbor algorithm had an accuracy of 90% (45 of 50), the naive Bayes algorithm had an accuracy of 84% (42 of 50), the discriminant analysis algorithm had an accuracy of 78% (39 of 50), and the support vector machine algorithm had an accuracy of 76% (38 of 50). The K-nearest neighbor algorithm used 6 performance metrics to classify participants, the naive Bayes algorithm used 9 performance metrics, the discriminant analysis algorithm used 8 performance metrics, and the support vector machine algorithm used 8 performance metrics. Two neurosurgeons, 1 fellow or senior resident, 1 junior resident, and 1 medical student were misclassified.

"Conclusions and Relevance  In a virtual reality neurosurgical tumor resection study, a machine learning algorithm successfully classified participants into 4 levels of expertise with 90% accuracy. These findings suggest that algorithms may be capable of classifying surgical expertise with greater granularity and precision than has been previously demonstrated in surgery."

Available at  doi:10.1001/jamanetworkopen.2019.8363.

Subjects: Artificial Intelligence in Medicine , COMPUTING/MATHEMATICS in Medicine & Biology › Computer Simulation, COMPUTING/MATHEMATICS in Medicine & Biology › Visualization, Education, Biomedical, & Biomedical Profession, NEUROSURGERY › Neuro-oncology
  • 14015

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

Science, 266, 66-71, 1994.

Discovery of the BRCA1 gene using the technique of restriction fragment length polymorphism (RFLP).

(Thanks to Juan Weiss for this reference and its interpretation.)

Subjects: BIOLOGY › MOLECULAR BIOLOGY › Genomics › Personalized Medicine, GENETICS / HEREDITY › HEREDITARY / CONGENITAL DISEASES OR DISORDERS › Hereditary Cancers › Breast Cancer 1 & 2, ONCOLOGY & CANCER › Carcinoma
  • 14016

Location of a breast cancer susceptibility gene, BRACA2, to chromosome 13q12-13.

Science, 265, 2088-2090, 1994.

Stratton and colleagues discovered the BRCA2 gene. Oder of authorship in the original publication: Wooster, Neuhausen, Mangion....Stratton.

(Thanks to Juan Weiss for this reference and its interpretation.)

Subjects: BIOLOGY › MOLECULAR BIOLOGY › Genomics › Personalized Medicine, GENETICS / HEREDITY › HEREDITARY / CONGENITAL DISEASES OR DISORDERS › Hereditary Cancers › Breast Cancer 1 & 2
  • 14017

Graphic illustrations of abortion and the diseases of menstruation. Consisting of twelve plates from drawings engraved on stone, and coloured by Mr. J. Perry, and two copperplates from the Philosophical transactions, coloured by the same artist. The whole representing forty-five specimens of aborted ova and adventitious productions of the uterus, with preliminary observations, explanations of the figures, and remarks anatomical and physiological.

London: John Churchill, 1834.

Concerns miscarriage and aberrant gestation rather than removal or expulsion of embryo or fetus. Digital facsimile from at this link.

  • 14018

Agrobacterium rhizogenes inserts T-DNA into the genomes of the host plant root cells.

Nature, 295, 432-434, 1982.

Chilton was the first (1977) to demonstrate the presence of a fragment of Agrobacterium Ti plasmid DNA in the nuclear DNA of crown gall tissue. Her research on Agrobacterium also showed that the genes responsible for causing disease could be removed from the bacterium without adversely affecting its ability to insert its own DNA into plant cells and modify the plant's genome. Chilton described what she had done as disarming the bacterial plasmid responsible for the DNA transfer. Using Agrobacterium carrying the disarmed Ti plasmid, in 1983 Chilton and her collaborators produced the first genetically modified plants.

Subjects: BOTANY, Biotechnology › Genetic Engineering / Genetic Modification
  • 14019

The topographical anatomy of the child.

Edinburgh: E. & S. Livingstone Ltd., 1887.

The first part of this work concerns cross-sectional anatomy; the second part systematically discusses the differences between anatomy in children and adults of different parts of the body.

Subjects: ANATOMY › 19th Century, ANATOMY › Child, ANATOMY › Cross-Sectional
  • 14020

The anatomical basis of medical practice.

Baltimore: Williams & Wilkins, 1971.

A notorious anatomy textbook that was pulled from the market by the publisher due to protest over its use of Playboy magazine type models to illustrate female external anatomy, as well as its sexist language. Preface: "Perhaps we should have included photographs of garden-variety, American males and females who have let their physiques go to pot. Instead, we used female models as model females. The student will see the ordinary specimen every day. Only on rare occasions will the attractive, well-turned specimen appear before him for consultation. He should be prepared for this pleasant shock. For the growing ranks of female medics, we included the body beautiful of a robust, healthy male. We are sorry that we cannot make available the addresses of the young ladies who grace our pages. Our wives burned our little address books at our last barbecue get-together" (p. vii). Rosalind A. Coleman & James Rolleston, "Anatomy Lessons: The Destiny of a Textbook, 1971-72", South Atlantic Quarterly,  90, (1991), 153-73. Edward C. Halperin, "The Pornographic Anatomy Book? The Curious Tale of 'The Anatomical Basis of Medical Practice'," (published in Duke Medicine). 

Subjects: ANATOMY › 20th Century
  • 14021

The anatomy of the infant head.

Baltimore, MD: The Johns Hopkins University Press, 1986.

Subjects: ANATOMY › 20th Century, ANATOMY › Child
  • 14022

The complete sequence of a human genome.

Science, 376, 44-53, 2022.

The first sequence of the complete human genome, telomere to telomere, including transcriptional and epigenetic state of the repeat elements, adding 8% novel genome information left unresolved since the 2001 draft sequence. Order of authorship in the original publication: Nurk, Koren, Rhie...Miga. 

(Thanks to Juan Weiss for this reference and its interpretation.)

  • 14023

An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.

Science, 374, 1586-1593, 2021.

The authors showed how a coronavirus specific protease inhibitor designed in the lab, that could be administered by mouth to humans, achieved excellent plasma concentrations and antiviral potency. This drug, marketed as Pfizer's Paxlovid, was the first successful outpatient medicine for the treatment of COVID-19.
Order of authorship in the original publication: Owen, Allerton, Anderson.

(Thanks to Juan Weiss for this reference and its interpretation.)

Subjects: EPIDEMIOLOGY › Pandemics › COVID-19, INFECTIOUS DISEASE › SARS CoV-2 (Cause of COVID-19) › Multisystem Inflammatory Disease in Children (MIS-C), PHARMACOLOGY › PHARMACEUTICALS › Antiviral Drugs, VIROLOGY › VIRUSES (by Family) › Coronaviruses (Coronaviridae) › SARS CoV-2 (Cause of COVID-19)
  • 14024

A brief history of macromolecular crystallography, illustrated by a family tree and its Nobel fruits.

FEBS Journal, 281, 3985-4009, 2014.

Free access from FEBS Press at this link.

Subjects: BIOLOGY › MOLECULAR BIOLOGY › History of Molecular Biology, BIOLOGY › MOLECULAR BIOLOGY › Protein Structure, BIOLOGY › MOLECULAR BIOLOGY › X-Ray Crystallography
  • 14025

The isolation and crystallization of the enzyme urease.

J. Biol. Chem., 69, 435-441, 1926.

Sumner (Nobel Prize 1946) first isolated and crystallized an enzyme (urease) and proved that enzymes are proteins.

Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Structure, BIOLOGY › MOLECULAR BIOLOGY › X-Ray Crystallography
  • 14026

Highly accurate protein structure prediction with AlphaFold.

Nature, 596, 583-589, 2021.

"Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function. Through an enormous experimental effort1,2,3,4, the structures of around 100,000 unique proteins have been determined5, but this represents a small fraction of the billions of known protein sequences6,7. Structural coverage is bottlenecked by the months to years of painstaking effort required to determine a single protein structure. Accurate computational approaches are needed to address this gap and to enable large-scale structural bioinformatics. Predicting the three-dimensional structure that a protein will adopt based solely on its amino acid sequence—the structure prediction component of the ‘protein folding problem’8—has been an important open research problem for more than 50 years9. Despite recent progress10,11,12,13,14, existing methods fall far short of atomic accuracy, especially when no homologous structure is available. Here we provide the first computational method that can regularly predict protein structures with atomic accuracy even in cases in which no similar structure is known. We validated an entirely redesigned version of our neural network-based model, AlphaFold, in the challenging 14th Critical Assessment of protein Structure Prediction (CASP14)15, demonstrating accuracy competitive with experimental structures in a majority of cases and greatly outperforming other methods. Underpinning the latest version of AlphaFold is a novel machine learning approach that incorporates physical and biological knowledge about protein structure, leveraging multi-sequence alignments, into the design of the deep learning algorithm."

Order of authorship in the original publication: Jumper, Evans...Hassabis.  Open access from Nature at this link.

Subjects: Artificial Intelligence in Medicine , BIOLOGY › MOLECULAR BIOLOGY › Protein Structure
  • 14027

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models.

Nucleic Acids Research, 50, D439-D444, 2022.

"The AlphaFold Protein Structure Database (AlphaFold DB, is an openly accessible, extensive database of high-accuracy protein-structure predictions. Powered by AlphaFold v2.0 of DeepMind, it has enabled an unprecedented expansion of the structural coverage of the known protein-sequence space. AlphaFold DB provides programmatic access to and interactive visualization of predicted atomic coordinates, per-residue and pairwise model-confidence estimates and predicted aligned errors. The initial release of AlphaFold DB contains over 360,000 predicted structures across 21 model-organism proteomes, which will soon be expanded to cover most of the (over 100 million) representative sequences from the UniRef90 data set."

Open access from at this link.

Subjects: Artificial Intelligence in Medicine , BIOLOGY › MOLECULAR BIOLOGY › Protein Structure
  • 14028

Experimental physiology: Its benefits to mankind, with an address on unveiling the statue of William Harvey at Folkestone 6th August 1881.

London: Longmans, Green & Co., 1882.

A little-known historical work on the history of physiology and the history of medicine by Owen, who, even though he was trained in medicine, most often wrote on topics in comparative anatomy, zoology, paleontology and evolution. Digital facsimile from the at this link.

  • 14029

Body counts: Medical quantification in historical and sociological perspective / La quantificattion medicale, perspectives historiques et sociologigues. Edited by Gérard Jorland, Annick Opinel and George Weisz.

Montréal: McGill-Queen's University Press, 2005.

Subjects: COMPUTING/MATHEMATICS in Medicine & Biology › History of Computing / Mathematics in Medicine & Biology, DEMOGRAPHY / Population: Medical Statistics › History of Demography
  • 14030

History of hospitals in Iran, 550-1950.

Washington, DC: Mage Publishers, 2021.

Subjects: COUNTRIES, CONTINENTS AND REGIONS › Iran (Persia), HOSPITALS › History of Hospitals
  • 14031

The beginnings of modern medicine in Iran.

Washington, DC: Mage Publishers, 2020.

Subjects: COUNTRIES, CONTINENTS AND REGIONS › Iran (Persia), Persian (Iranian) Islamic Medicine › History of Persian (Iranian) Islamic Medicine
  • 14032

Studies in the history of medicine in Iran.

Washington, DC: Mage Publishers, 2018.

Subjects: COUNTRIES, CONTINENTS AND REGIONS › Iran (Persia), Persian (Iranian) Islamic Medicine › History of Persian (Iranian) Islamic Medicine
  • 14033

Public health in Qajar Iran.

Washington, DC: Mage Publishers, 2004.

"Until Now, there have been no books and only a few articles available in English that deal with the actual practice of medicine in nineteenth and early twentieth-century Iran. Willem Floor’s Public Health in Qajar Iran fills this lacuna, giving a broad and comprehensive survey of the state of public health, medical practice, and its practitioners in 1800-1925. Based on firsthand accounts of European travelers and doctors who practiced and observed medical treatment, the study provides an overview of the major diseases the population suffered and how these were treated. It also includes the available evidence logged by Iranian patients abroad and at home, as well as contemporary Persian texts that comment on public health and its practice in Iran.

"Floor shuns the analysis of classic Islamic medical textbooks, explaining that their medical advice was hardly ever administered and that the authors often had ideological (religious) agendas in writing these treatises. Instead, Floor investigates the commonly accepted theories of diseases, disorders, and their cures, including Islamic Galenic medicine and pre-Islamic theurgic folk medicine based on traditional herb lore and trial-and-error. The book concludes with the impact of Western medicine on the traditional medical institutions and public health in Qajar Iran..." (publisher)

Subjects: COUNTRIES, CONTINENTS AND REGIONS › Iran (Persia), PUBLIC HEALTH › History of Public Health, Persian (Iranian) Islamic Medicine › History of Persian (Iranian) Islamic Medicine
  • 14034

Le passage du virus rabique à travers les filtres.

Ann. Inst. Pasteur, 17, 834-849, 1903.

By demonstrating that the rabies organism is filterable Remlinger proved that rabies is a virus. The rabies virus was the second virus causing disease in humans to be identified. Remlinger made his discovery by following Walter Reed's technique used to identify the yellow fever virus, published by Reed in 1902.

(Thanks to Juan Weiss for this reference and its interpretation.)

Subjects: VIROLOGY › VIRUSES (by Family) › Rhabdoviridae › Rabies Lyssavirus
  • 14035

The nature of the Negri Body.

J. Cell Biol., 27, 677-682, 1965.

The first visual proof, by publication of electron micrographs at 25,000 magnification, that Negri bodies contain enormous numbers of rabies virus particles. Digital facsimile from at this link.

(Thanks to Juan Weiss for this reference and its interpretation.)

Subjects: IMAGING › Photography / Photomicrography , VIROLOGY › VIRUSES (by Family) › Rhabdoviridae › Rabies Lyssavirus
  • 14036

Old English silver and its medical interest. Presidential Address, Liverpool Medical Institution, 14th October 1954.

Liverpool: Samuel Hill and Reader Ltd., 1955.

Digital facsimile from at this link.

Subjects: INSTRUMENTS & TECHNOLOGIES › History of Biomedical Instrumentation
  • 14037

Persien. Das Land und seine Bewohner. Ethnographische Schilderungen. 2 vols.

Leipzig: F. A. Brockhaus, 1865.

In this wide-ranging ethnographic study Polak provided the most authoritative account of his introduction of western medicine into Iran as well as the state of medicine in Iran generally. "Polak (1865, II, pp. 192-348) devoted five chapters to exclusively medical topics. He describes the various health care professionals, their income, status and methods of treatment, as well as narcotics, poisons, and antidotes. He provides an encyclopedic list of common diseases, followed by a practical section on travel advice for foreigners, even including psychological problems of acculturation (Polak, 1865, II, pp. 349-60). Although he is not completely free from Orientalist misconceptions and remains strongly convinced of the overall superiority of the West, his detailed observations are extremely valuable. His medical practice allowed him to gain unique insights into Qajar society. For example, Polak (1865, I, p. 204) soberly notes the occurrence of a perineal tear in girls as resulting from marriage before puberty—nowadays this is considered child rape" (Encyclopedia Iranica). Digital facsimile from the Internet Archive at this link.

Subjects: ANTHROPOLOGY › Ethnology, COUNTRIES, CONTINENTS AND REGIONS › Iran (Persia), Travels by Physicians, Surgeons & Scientsts
  • 14038

The process of tendon repair: An experimental study of tendon suture and tendon graft.

Archives of surgery, 25, 615-692, 1932.

Subjects: ORTHOPEDICS › Orthopedic Surgery & Treatments › Hand / Wrist, PLASTIC & RECONSTRUCTIVE SURGERY › Hand, Surgery of
  • 14039

Essai de géographie médicale de l'Ille Nosi-Bé près la cote nord-ouest de Madagascar (avec cartes). Thèse pour le doctorat en médicine.

Paris: A. Parent, 1883.

Subjects: Biogeography, COUNTRIES, CONTINENTS AND REGIONS › Madagascar, Geography of Disease / Health Geography
  • 14040

Deer Leibarzt des Schah Jacob E. Polak 1818-1891. Eine west-östliche Lebensgeschichte.

Vienna: New Academic Press, 2019.

Subjects: BIOGRAPHY (Reference Works) › Biographies of Individuals, Persian (Iranian) Islamic Medicine › History of Persian (Iranian) Islamic Medicine
  • 14041

Race and the odd history of human paleontology.

Anatomical Record (Pt. B: New Anat.), 2898, 225-240, 2006.

Abstract: "Although the late 17th century witnessed the recognition of fossils as the remains of extinct organisms—because they could be incorporated into the creation story embodied in the Great Chain of Being—acceptance of human antiquity through the indisputable demonstration of the contemporaneity of human bones, stone tools, and accepted fossils was not forthcoming for nearly 2 centuries thereafter. When it did occur, however, ancient humans were not seen as presenting a pattern of diversity similar to that seen in the fossil records of nonhuman organisms. Instead, human evolution then, as now, has typically been interpreted as being unilinear. This belief can be traced to Huxley (1863), who argued that the Feldhofer Grotto Neanderthal skullcap was merely an extension into the past of morphology seen in the Australian Aborigine, whom he took to represent the primitive end of an extreme range of variation he thought characterized Homo sapiens. During the mid-20th century, Mayr and Dobzhansky (mis)used their clout as founders of the evolutionary synthesis to cement in paleoanthropology the idea that human evolutionary history was characterized by nonspeciation. As such, anything that could be interpreted as potentially representing taxic diversity was relegated to the status of individual variation. Lack of understanding of the history of human paleontology, and the biases that constrained its perspective on human evolution, continue to affect the ways in which most paleoanthropologists pigeonhole human fossils."

Subjects: ANTHROPOLOGY › History of Anthropology, ANTHROPOLOGY › Paleoanthropology, ANTHROPOLOGY › Physical Anthropology
  • 14042

The reputed fossil man of the Neanderthal.

Quarterly Journal of Science, I, 88-97, 1864.

King believed that the Feldhofer Neanderthal skull discovered by Fuhrott and Schaafhausen differed significantly from all known ancient and modern human crania. In this paper he proposed the name Homo neanderthalensis in order to distinguish the Feldhofer specimen from anatomically modern Homo sapiens; thus this paper is the source of the term “Neanderthal Man.”

King "noted the differences in the curved ribs, the skull muscle attachment suggesting carnivory and suggested that the Neanderthal was a species different from modern humans. He supported a modified version of Darwin's Origin of Species but he gave considerable emphasis to place the Neanderthal as being close and on a "lower scale" than Andaman and Australian aborigines and suggested that like them, the Neanderthal was "incapable of moral and theoistic conception".  (Wikipedia article on William King (geologist) ).

Subjects: ANTHROPOLOGY › Paleoanthropology, ANTHROPOLOGY › Physical Anthropology
  • 14043

Patents on life: Religious, moral, and social justice aspects of biotechnology and intellectual property. Edited by Thomas C. Berg, Roman Cholij, and Simon Ravenscroft.

Cambridge & New York: Cambridge University Press, 2020.

Subjects: Biotechnology, Ethics, Biomedical, LAW and Medicine & the Life Sciences, RELIGION & Medicine & the Life Sciences
  • 14044

The orders of mammals. Part 1.- Typical stages in the history of the ordinal classification of mammals. Part II. - Genetic relations of the mammalian orders; with a discussion of the origin of the mammalia and of the problem of the auditory ossicles.

Bull. Amer. Mus. Nat. Hist., 27, 1-524, [1], 1910.

Gregory's PhD dissertation, of particular significance for its exhaustive analysis of prior taxonomic systems for mammalia. Digital facsimile from Google Books at this link.

Subjects: BIOLOGY › TAXONOMY › Taxonomy - Animals, ZOOLOGY › Mammalogy
  • 14045

On the extent and aims of a national museum of natural history.

London: Saunders, Otley & Co., 1862.

Owen was the prime mover behind the construction of the Natural History Museum, a project that occupied him for over two decades. His On the Extent and Aims of a National Museum of Natural History, containing the text of his lecture delivered before the Royal Institution in April 1861, was part of his long campaign to obtain political backing for the South Kensington Museum.

After Owen's appointment as superintendent of the Natural History department of the British Museum in 1856, dissatisfied with the cramped and disorganized confines of the existing British Museum (located in Bloomsbury), Owen began lobbying for a "separate but unified national museum of natural history . . . to represent the three kingdoms of nature" (Rupke, p. 34), to be housed in a building spacious enough to display even the largest specimens of both living and fossil species. The project did not really get off the ground until October 1861, when "manipulated future Prime Minster Gladstone into the opinion that the current exhibition facilities for the Natural History Department of the British Museum were inadequate for their task. Owen cultivated Gladstone's support in order to bring the issue before Parliament once the Trustees of the British Museum fell into agreement with his extravagant plans for building not just more display space, but an entirely new building to house the natural history collection (Johnson-Roehr, "The Natural History Museum-London" [internet reference]).

After much heated debate, Owen's plan was approved and the South Kensington museum, designed by Albert Waterhouse, began construction in 1873. The building was completed by late 1879, and the museum opened its doors to the public in 1881. The social and cultural impact of Owen's Natural History Museum cannot be overestimated: Bill Bryson, in his Short History of Nearly Everything (2003), stated that "by making the Natural History Museum an institution for everyone, Owen transformed our expectations of what museums are for" (p. 81).

Digital facsimile from Google Books at this link.

Subjects: MUSEUMS › Natural History Museums / Wunderkammern
  • 14046

The lac Operon: A short history of a genetic paradigm.

Berlin & New York: Walter de Gruyter, 1996.

Subjects: BIOLOGY › MOLECULAR BIOLOGY › History of Molecular Biology
  • 14047

The origin of human races and the antiquity of man deduced from the theory of “natural selection."

J. Anthrop. Soc. London, 2, xlviii-clxxxvii, 1864.

Wallace delivered this paper to the polygenist Anthropological Society of London on 1 March 1864. It represents “the first effort to connect natural selection to the touchy problem of the evolution of human races” (Wallace 1991, 26), a topic that Huxley broached in his Evidence of Man's Place in Nature (1863) but which Darwin avoided until his Descent of Man (1871).

Wallace argued that man is fundamentally different from all other species because of the nature of the human mind, which enabled him “to remove his body from the modifying influence of external conditions, and the cumulative action of natural selection.” Though Wallace shares credit with Darwin for the theory of evolution by natural selection, Wallace differed fundamentally from Darwin in his attempt to distinguish the effect of natural selection upon man from its effect on the rest of living things. 

Subjects: ANTHROPOLOGY › Anthropology, EVOLUTION
  • 14048

An inconvenient truth. The planetary emergency of global warming and what we can do about it.

New York: Rodale Press, 2006.

A politician, Gore was one of the first to draw popular attention to climate change. He supplemented the best-selling book with a film and DVD with the same title. Ten years later, recognizing that in spite of its wide circulation, his first effort had not had sufficient impact on governmental or social policies, Gore issued An inconvenient sequel, truth to power. Your action handbook to learn the science, find your voice and help solve the climate crisis. New York: Rodale Press, 2017. In spite of the social urgency expressed in the sequel, no film or DVD version was produced, and the impact of the sequel was limited.

(Thanks to Juan Weiss for this reference and its interpretation.)

Subjects: BIOLOGY › Ecology / Environment › Climate Change
  • 14049

Climate change increases cross-species viral transmission risk.

Nature, 607, 551-561, 2022.

1) Using a phylogeographical model of the mammal-virus network, and projections of geographical range shifts, the authors assert that 3,139 mammal species will aggregate in new combinations at high elevations, seeking respite from rising heat.

2) Further they state that most mammalian species will have a range that overlaps with that of at least one previously unfamiliar species, and that more than 300,000 new cross-species encounters will occur globally, especially in tropical Africa and southeast Asia. They project that this will lead to a doubling in the number of cross-species contacts. They add that tropical hotspots of novel viral sharing will broadly coincide with areas of high population density, such as India, Indonesia, eastern China and the Philippines, by 2070.

3) They state that bats will become key drivers of altered virus sharing under climate change. Bats are known for their ability to harbor and transmit emergent pathogens. Furthermore, as winged mammals, bats are well positioned to respond to changing environmental conditions by taking flight and migrating to higher elevations or elsewhere.

4) The authors indicate that these ecological transitions are already underway, and that holding warming under 2 degrees Celsius in the 21st century will not reduce viral sharing.

5) The authors indicate that birds have the best documented virome after mammals, and account for the majority of non-mammalian reservoirs of zoonotic viruses. Thus changing bird migration patterns in a warming world will have a special impact on transmission.

6) Lastly, they state that climate change could easily become the dominant anthropogenic force in viral cross-species transmission.

Order of authorship in the original publication: Carlson, Albery, Merow....

(Thanks to Juan Weiss for this reference and its interpretation.)

Subjects: BIOLOGY › Ecology / Environment › Climate Change, EPIDEMIOLOGY › Pandemics
  • 14050

The great pox. The French disease in Renaissance Europe.

New Haven, CT: Yale University Press, 1996.

Subjects: INFECTIOUS DISEASE › SEXUALLY TRANSMITTED DISEASES › History of Sexually Transmitted Diseases
  • 14051

Abrégé historique des hopitaux, contenant leur origine, les différentes especes d’hopitaux, d’hospitaliers et hospitalieres, et les suppressions et changemens faits dans les hôpitaux, en France, par les édits et réglemens de nos rois .…

Paris: Chez Guillot, 1784.

A history of hospitals in France from the earliest times, through charitable care for the poor by monks and nuns, to their evolution through legislation of the 16th and 17yh centuries. Includes a list of charitable institutions for the care of the poor no longer in existence by Recalde's time, arranged alphabetically by town from Aix to Verdun, and articles drawn from 17th and 18th century legislation, covering  hospital personnel, the keeping of records and accounts, attendance to the sick by doctors, surgeons and their students, bandaging of the wounded, patients’ diet (comprising meat of good quality, bread, cereal, red or white wine or beer, salt, vinegar, eggs, rice, and prunes), hospital beds and linen; spring cleaning (whitewashing, eradicating insects etc.)

Subjects: HOSPITALS › History of Hospitals
  • 14052

The arsenal of eighteenth-century chemistry: The laboratories of Antoine Laurent Lavoisier (1743-1794) by Marco Beretta and Paolo Brenni.

Leiden & Boston: Brill, 2022.

"The substantial collection of Antoine Laurent Lavoisier’s apparatus is not the only surviving collection of eighteenth-century chemical apparatus and instrumentation, but it is without question the most important. The present study provides the first scientific catalogue of Lavoisier’s surviving apparatus. This collection of instruments is remarkable not only for the quality of many of them but, above all, for the number of items that have survived (ca. 600 items). Given such a wealth and variety of instruments, this study also offers the first comprehensive attempt to reconstruct the cultural and social context of Lavoisier’s experimental activities" (publisher).

Subjects: Chemistry › History of Chemistry, INSTRUMENTS & TECHNOLOGIES › History of Biomedical Instrumentation
  • 14053

A preliminary atlas of early human fetal activity.

Pittsburgh, PA: For the Author, 1939.

The first published photographic study of fetal physiology using live human fetuses. Includes 20 full-age photographic plates, each with 6-12 images (189 total). The fetuses, all between 8.5 and 14 weeks gestation, were obtained by surgical abortion "undertaken in the interest of the health, sanity or life of the mother." During a secretive departmental study begun in 1932 Hooker and team used horse hairs to stroke the face, body, arms and legs of fetus and filmed their reflexes with a motion picture camera. When the studies were conducted the specimens were technically still alive but had been separated from the placenta, resulting in asphxia and death within 13 minutes. 

Subjects: OBSTETRICS & GYNECOLOGY › OBSTETRICS › Abortion, PHYSIOLOGY › Fetal Physiology
  • 14054

Tibetan medical thangka of the four medical tantras. Translator and compiler of the original edition: Byams-pa 'Phrin-Las, Wang lei. English translator and annotator Cai Jingfeng.

Lhasa, Tibet: People's Publishing House of Tibet, 1988.

Subjects: ART & Medicine & Biology, COUNTRIES, CONTINENTS AND REGIONS › Tibet
  • 14055

Preliminary examination of lunar samples from Apollo 11: A physical, chemical, mineralogical, and biological analysis of 22 kilograms of lunar rocks and fines.

Science, 165, 1211-1227, 1969.

On p. 1226 the massive number of authors reported that "microscopic, culture, injection and inoculation studies on many different organisms to include mice, fish, invertebrates, insects, plants and lower animals such as parmecium, found that as of September 11, 1969, no evidence of pathogenicity has been observed."

See also: Vance I. Oyama, Edward L. Merek and Melvin P. Silverman, "A search for viable organisms in a lunar sample," Science, 167, 773-775. 
The authors found that "no viable life forms, including terrestrial contaminants, were found when the sample was tested in 300 separate environments," ending with "we conclude for this sample of the moon that there was no viable life present."

(Thanks for Juan Weiss for these references and their interpretation.)

Subjects: BIOLOGY › Astrobiology / Exobiology / Abiogenesis
  • 14056

Pheromones (ectohormones) in insects.

Annual Review of Entomology, 4, 39-58, 1959.

Karlson and Butenandt (Nobel Prize 1939) defined pheromones as “substances which are secreted to the outside by an individual of the same species, in which they release a specific reaction, for example, a definite behavior or a developmental process.” They distinguished between pheromones acting via olfaction and those acting via oral or ingestive routes. The former produced immediate releasing responses (e.g., initiating and guiding the flight of the male silk worm moth, Bombyx mori, to the female) and the latter delayed endocrine or reproductive effects, such as the caste-determining substances of many social insects.

(Thanks to Juan Weiss for this reference and its interpretation.)

Subjects: BIOLOGY › Pheromones, ZOOLOGY › Arthropoda › Entomology