An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to Circa 2020 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15423 entries, 13280 authors and 1897 subjects. Updated: October 17, 2021

Browse by Entry Number 700–799

120 entries
  • 700

La fermentation alcoolique.

Rev. sci. (Paris), 16, 49-56, 1878.

Bernard disbelieved Pasteur’s definition of a ferment as “a living form originating from a germ”.



Subjects: BIOCHEMISTRY, Zymology (Zymurgy) (Fermentation)
  • 700.1

Erfahrungen und Bemerkungen über Enzyme und Fermente.

Untersuch. physiol. Inst. Univ. Heidelberg, 1, 291-324, 1878.

Kühne introduced the term “enzyme”.



Subjects: BIOCHEMISTRY, Zymology (Zymurgy) (Fermentation)
  • 701

Physiologische Chemie.

Berlin: A. Hirschwald, 1881.

Hoppe-Seyler, one of the greatest of the physiological chemists, founded the Zeitschrift für physiologische Chemie and wrote a classical textbook on the subject.



Subjects: BIOCHEMISTRY
  • 702

Zur Chemie des Zellkerns.

Hoppe-Seyl. Z. physiol. Chem., 7, 7-22; 1886.10, 248-64; 22, 176-87, 18821883, 18961897.

Among the many important contributions of Kossel was his study of the chemistry of the cell and cell-nucleus. He was professor of physiology at Marburg and Heidelberg and was awarded the Nobel Prize for Physiology in 1910.



Subjects: BIOCHEMISTRY, BIOLOGY › MOLECULAR BIOLOGY › Nucleic Acids
  • 703

Enny Methode til kvaelstofbestemmelse i organiske Stoffer.

Medd. Carlsberg Lab. (Kbh.), 2, 1-27, 1883.

Kjeldahl, a Danish chemist, devised a method of determining the amount of nitrogen in an organic compound (“Kjeldahl’s method”). A German translation is in Z. anal. Chem., 1883, 22, 366-82.



Subjects: BIOCHEMISTRY
  • 704

Ueber eine neue linksdrehende Säure (Pseudooxybuttersäure).

Z. Biol., 20, 165-78; 23, 329-39, 1884, 1887.

Isolation of (ß-oxybutyric acid. (Title of second paper: Beiträge zur Kenntniss der activen ß-Oxybuttersäure).



Subjects: BIOCHEMISTRY
  • 705

Ueber Ptomaine. 3 vols.

Berlin: A. Hirschwald, 18851886.

Brieger isolated and determined the composition of a number of the ptomaines.



Subjects: BIOCHEMISTRY
  • 706

Lois d’équilibre chimique dans l’état dilué, gazeux ou dissous.

K. Svenska vetensk Akad. Handl., Stockh., 21, No. 17, pp. 1-41, 1885.

Van’t Hoff stated that osmotic pressure is proportional to the concentration if the temperature remains invariable, and proportional to the absolute temperature if the concentration remains invariable.



Subjects: BIOCHEMISTRY
  • 707

A text-book of human physiology, including histology and microscopical anatomy....by L. Landois. Translated from the fifth German edition. With additions by William Stirling. 2 vols.

London: Charles Griffin and Company, 1886.

Second edition in English. Matthew Hay devised a test for the determination of bile acids in the urine, published in vol. 1, p. 381.
Digital facsimile from the Hathi Trust at this link.



Subjects: BIOCHEMISTRY, BIOCHEMISTRY › Clinical Chemistry
  • 708

Ueber den Niederschlag, welchen Pikrinsäure in normalen Harn erzeugt und über eine neue Reaction des Kreatinins.

Hoppe-Seyl. Z. physiol. Chem. 10, 391-400., 1886.

Jaffe’s creatinine test.



Subjects: BIOCHEMISTRY, BIOCHEMISTRY › Clinical Chemistry
  • 709

Ueber die Dissociation der in Wasser gelösten Stoffe.

Z. Physikal. Chem. 1, 631-48, 1887.

The electrolytic dissociation theory of Arrhenius.



Subjects: Chemistry
  • 710

Lehrbuch der physiologischen und pathologischen Chemie.

Leipzig: F. C. W. Vogel, 1887.


Subjects: BIOCHEMISTRY
  • 711

Die Rolle des osmotischen Druckes in der Analogic zwischen Lösungen und Gasen.

Z. physikal. Chem., 1, 481-508, 1887.


Subjects: Chemistry
  • 712

Ptomaines and leucomaines, or the putrefactive and physiological alkaloids.

Philadelphia: Lea Brothers & Co., 1888.


Subjects: BIOCHEMISTRY
  • 713

Ueber Nucleinsäuren.

Arch. Anat. Physiol., Physiol. Abt., 524-36, 1889.

Atlmann coined the term "nucleic acid", replacing Friedrich Miescher's term "nuclein" when it was demonstrated that nuclein was acidic.

 



Subjects: BIOLOGY › MOLECULAR BIOLOGY, BIOLOGY › MOLECULAR BIOLOGY › Nucleic Acids
  • 714

Fixation de l’azote par la terre végétale nue ou avec le concours des légumineuses.

Rev. sci. (Paris), 43, 450-54, 1889.

Berthelot showed that bacteria acting in clay soils are able to fix nitrogen.



Subjects: BIOCHEMISTRY, BIOLOGY › Ecology / Environment
  • 715

Ueber den Einfluss der Alkalien auf den menschlichen Stoffwechsel.

Stuttgart: Ferdinand Enke, 1890.


Subjects: BIOCHEMISTRY
  • 716

Der Abbau der Eiweissstoffe.

Arch. Anat. Physiol. Abt., 248-78, 1891.

Drechsel discovered that the protein molecule contains both mono and di-amino acids.



Subjects: BIOCHEMISTRY
  • 717

The behaviour of saccharine matter in the blood.

J. Physiol. (Lond.), 12, 391-408, 1891.

Destruction of sugar in the blood.



Subjects: BIOCHEMISTRY › Metabolism, HEMATOLOGY
  • 718

On the estimation of uric acid in the urine: a new process by means of saturation with ammonium chloride.

Proc. Roy. Soc., 52, 93-98, 1892.

Hopkins’s method of estimating uric acid in urine.



Subjects: BIOCHEMISTRY, BIOCHEMISTRY › Clinical Chemistry
  • 719

Ueber die Nucleinsaure.

Arch. Anat. Physiol., Physiol. Abt., 157-64; 194-203, 1893, 1894.

See No. 702.



Subjects: BIOCHEMISTRY, BIOLOGY › MOLECULAR BIOLOGY › Nucleic Acids
  • 719.1

Alkoholische Gärung ohne Hefezellen.

Ber. dtsch. chem. Ges., 30, 117-24, 1110-13, 2668-78, 1897.

Discovery of cell-free fermentation, the turning point in the study of enzymes. Buchner received the Nobel Prize for Chemistry in 1907 for this work. Third paper written with R. Rapp.



Subjects: BIOCHEMISTRY, Zymology (Zymurgy) (Fermentation)
  • 720

Bedeutung der Stereochemie fur die Physiologie.

Hoppe-Seyl. Z. physiol. Chem., 26, 60-87, 18981899.


Subjects: BIOCHEMISTRY
  • 721

Ueber die Eiweissstoffe.

Dtsch. med. Wschr., 24, 581-82, 1898.

Kossel forecast the polypeptide nature of the protein molecule.



Subjects: BIOCHEMISTRY, BIOLOGY › MOLECULAR BIOLOGY
  • 722

Concerning lipase, the fat-splitting enzyme, and the reversibility of its action.

Amer. chem. J., 24, 491-525, 1900.

Demonstration of the reversible action of lipase.



Subjects: BIOCHEMISTRY
  • 723

A contribution to the chemistry of proteids. I. A preliminary study of a hitherto undescribed product of tryptic digestion.

J. Physiol. (Lond.), 27, 418-28, 1901.

Isolation of tryptophan.



Subjects: BIOCHEMISTRY
  • 724

Physikalische Chemie der Zelle und Gewebe.

Leipzig: Wilhelm Engelmann, 1902.


Subjects: BIOCHEMISTRY
  • 725

Osmotischer Druck und Ionenlehre in den medicinischen Wissenschaften. 3 vols.

Wiesbaden: J. F. Bergmann, 19021904.

Includes an account of all the methods of determining osmotic pressure.



Subjects: BIOCHEMISTRY, BIOLOGY › Cell Biology
  • 725.1

Darstellung und Analyse einiger Nucleinsäuren. I.-VI. Mittheilung.

Hoppe-Seyl. Z. physiol. Chem., 32, 541-552; 37, 402-406; 38, 81-83; 39, 4-8, 133-35, 479-83, 19011903.

Chemical distinction between DNA and RNA. Levene elucidated the fundamentals of nucleic acid chemistry. His work led to the tetranucleotide hypothesis.



Subjects: BIOCHEMISTRY, BIOLOGY › MOLECULAR BIOLOGY › Nucleic Acids
  • 726

Ueber einen in biologischer Beziehung wichtigen Einfluss, den die Kohlensäurespannung des Blutes auf dessen Sauerstoffbindung übt.

Skand. Arch. Physiol, 16, 402-12, 1904.

Bohr, Hasselbalch, and Krogh showed, in the experimental animal, that the affinity of blood for oxygen depends upon carbon dioxide pressure. This became known as the Bohr effect, though the discovery may have been made by Krogh. English translation in No. 1588.16.



Subjects: BIOCHEMISTRY, HEMATOLOGY
  • 727

Abbau und Aufbau der Eiweisskörper im tierischen Organismus.

Hoppe Seyl. Z. physiol. Chem., 44, 17-52, 1905.


Subjects: BIOCHEMISTRY
  • 728

Die Abbau aromatischer Fettsäuren im Tierkörper.

Beitr. chem. Physiol. Path., 6, 150-62, 1905.

ß-oxidation theory.



Subjects: BIOCHEMISTRY
  • 729

Zur Erkenntnis der Kolloide.

Jena: Gustav Fischer, 1905.


Subjects: BIOCHEMISTRY
  • 730

Untersuchungen über Aminosäuren, Polypeptide und Proteine. 2 vols.

Berlin: Julius Springer, 19061923.

In a series of papers, Fischer showed that animal and vegetable proteins are composed of a series of amino-acids united by elimination of water.



Subjects: BIOCHEMISTRY
  • 730.1

Note upon the presence of amino-acids in the blood and lymph as determined by the ß naphthalinsulphochloride reaction.

Amer. J. Physiol., 17, 273-79, 1906.

Demonstration of the presence of amino-acids in the blood.



Subjects: BIOCHEMISTRY, HEMATOLOGY
  • 731

On carbohydrate metabolism.

London: J. & A. Churchill, 1906.


Subjects: BIOCHEMISTRY
  • 732

The importance of individual amino-acids in metabolism.

J. Physiol. (Lond.), 35, 88-102, 1906.

Demonstration of the importance of tryptophan in diet. The pioneer work of Hopkins led eventually to the discovery of vitamins.



Subjects: BIOCHEMISTRY, WOMEN, Publications by › Years 1900 - 1999
  • 733

Lactic acid in amphibian muscle.

J. Physiol. (Lond.), 35, 247-309, 1907.

Explanation of the production of lactic acid in normal muscular contraction.



Subjects: BIOCHEMISTRY, BIOCHEMISTRY › Metabolism
  • 734

The oxidation of butyric acid by means of hydrogen peroxide with formation of acetone, aldehydes, and other products.

J. biol. Chem., 4, 77-89, 1908.

See No. 735.



Subjects: BIOCHEMISTRY
  • 735

Comparative studies of the mode of oxidation of phenyl derivatives of fatty acids by the animal organism and by hydrogen peroxide.

J. biol. Chem. , 4, 419-35; 5, 173-85, 303-09; 6, 203-43, 1908, 1909.

Dakin’s oxidation theory.



Subjects: BIOCHEMISTRY
  • 736

Ueber die kleinsten Moleküle, welche die Leber zur Synthese des Glykogenes verwerten kann.

Pflüg. Arch. ges. Physiol, 121, 636-40, 1908.


Subjects: BIOCHEMISTRY
  • 737

Kapillarchemie.

Leipzig: Akademische Verlagsgesellschaft, 1909.


Subjects: BIOCHEMISTRY
  • 738

Grundriss der Kolloidchemie.

Dresden: Steinkopff, 1909.


Subjects: BIOCHEMISTRY
  • 739

The oxidases and other oxygen-catalysts concerned in biological oxidations.

Washington, DC: Government Printing Office, 1910.

Hygienic Laboratory.- Bulletin No. 59. December, 1909.  Digital facsimile from the Internet Archive at this link.



Subjects: BIOCHEMISTRY
  • 740

Die Theorie des Haftdrucks (Oberflächendrucks) und ihre Bedeutung für die Physiologie.

Pflüg. Arch. ges. Physiol., 132, 511-38; 140, 109-34, 1910, 1911.


Subjects: BIOCHEMISTRY, PHYSIOLOGY
  • 741

Oxidations and reductions in the animal body.

London: Longmans, 1912.


Subjects: BIOCHEMISTRY
  • 741.1

A new method for the determination of total nitrogen in urine.

J. biol. Chem., 11, 493-501, 1912.

Folin introduced several micro-methods for the determination of nitrogen, urea, creatine, etc.



Subjects: BIOCHEMISTRY, BIOCHEMISTRY › Clinical Chemistry
  • 741.2

On the removal of diffusible substances from the circulating blood of living animals by dialysis.

J. Pharmacol., 5, 275-316, 1914.

Hemodialysis. See also No. 1976. Preliminary communication in Trans Ass. Amer. Phycns., 1913, 28, 51-4.

"Together with L.G. Rowntree and B.B. Turner, Abel devised what they called a "vividiffusion" apparatus, consisting of a series of tubes surrounded by fluid. They first demonstrated the apparatus at the Physiological Congress in Groningen in 1914.[9] By allowing arterial blood to enter at one end of the connection, and later return to circulation through the venous connection after dialysis, they were able to demonstrate the existence of free amino acids in blood. By isolating these amino acids from blood circulation, Abel conducted various subsequent researches on the structure of proteins in the blood. Not only did Abel use the apparatus for his research work, he also realized the great clinical potential such dialysis machine would have on managing the damaging effects of renal failure.[10] The vividiffusion apparatus Abel devised is the precursor to the modern day dialysis machine" (Wikipedia article on John Jacob Abel, accessed 08-2017).



Subjects: BIOCHEMISTRY, NEPHROLOGY › Renal Disease › Dialysis
  • 742

Die Berechnung der Wasserstoffzahl des Blutes aus der freien und gebundenen Kohlensäure desselben, und die Sauerstoffbindung des Blutes als Funktion der Wasserstoffzahl.

Biochem. Zeit., 78, 112-144, 1917.

Henderson-Hasselbalch equation for the determination of pH concentration in the blood. English translation in No. 1588.16. For Henderson's papers see No. 9645



Subjects: BIOCHEMISTRY, BIOCHEMISTRY › Clinical Chemistry, HEMATOLOGY
  • 743

The action of the boiled pancreas extract on yeast nucleic acid.

Amer. J. Physiol., 52, 203-7, 1920.

Ribonudease.



Subjects: BIOCHEMISTRY
  • 744

Rapid colorimetric methods for the determination of phosphorus in urine and blood.

J. biol. Chem., 44, 55-67, 1920.


Subjects: BIOCHEMISTRY, BIOCHEMISTRY › Clinical Chemistry
  • 745

On an autoxidisable constituent of the cell.

Biochem. J., 15, 286-305, 1921.

Isolation of glutathione.



Subjects: BIOCHEMISTRY
  • 746

The possible significance of hexosephosphoric esters in ossification.

Biochem. J., 17, 286-93, 1923.

Records an important advance in the knowledge concerning the conversion of blood calcium into the insoluble calcium of bone.



Subjects: ORTHOPEDICS › Muskuloskeletal System › Physiology of Bone Formation
  • 747

Studies in nuclein metabolism. II. The isolation of a nucleotide from human blood.

J. biol. Chem., 59, 529-34, 1924.

Jackson demonstrated the existence of pentose nucleotides in normal blood.



Subjects: BIOCHEMISTRY, HEMATOLOGY
  • 748

Chemical dynamics of life phenomena.

Philadelphia: J. B. Lippincott, 1924.


Subjects: BIOCHEMISTRY
  • 749

A study of the oxidation of the ammonium salts of normal saturated fatty acids and its biological significance.

Biochem. J., 19, 385-96, 1925.


Subjects: BIOCHEMISTRY
  • 750

Ueber die katalytischen Wirkungen der lebendigen Substanz.

Berlin: Julius Springer, 1928.


Subjects: BIOCHEMISTRY
  • 751

Phosphorus compounds of muscle and liver.

Science, 70, 381-382, 1929.

Discovery of adenosine-5′-triphosphate (ATP).



Subjects: BIOCHEMISTRY
  • 751.1

Citric acid in intermediate metabolism in animal tissues.

Enzymologia, 4, 148-56, 1937.

Citric acid cycle (CAC) of aerobic carbohydrate metabolism (Krebs cycle). Three months after his initial publication on CAC Krebs published a supplementary paper aimed at the medical audience, rather than the biochemical audience that read Enzymologia:  "The intermediate metabolism of carboyhdrates," Lancet, 230 (1937) 736-41. Krebs shared the Nobel Prize with Fritz Lipmann (No. 751.3) in 1953.

(Thanks to Juan Weiss for recommending the supplementary paper.)



Subjects: BIOCHEMISTRY › Metabolism
  • 751.2
  • 912.4

Chemical, clinical, and immunological studies on the products of human plasma fractionation. I. The characterization of the protein fractions of human plasma.

J. clin. Invest., 23, 417-32, 1944.

Cohn invented fractionation of plasma proteins, also called blood fractionation. (Order of authorship in the original publication: Cohn, Oncley, Strong, Hughes, Armstrong.) Digital facsimile from PubMedCentral at this link.



Subjects: BIOCHEMISTRY, HEMATOLOGY
  • 751.3

A common factor in the enzymatic acetylation of sulfanilamide and of choline.

J. biol. Chem., 162, 743-44, 1946.

For his co-discovery in 1945 of coenzyme A, together with other research on coenzyme A,  Lipmann shared the 1953 Nobel Prize in Physiology or Medicine with Sir Hans Krebs.



Subjects: BIOCHEMISTRY
  • 751.4

Enzymatic reactions in carbohydrate metabolism.

Harvey Lect. (1945-46), 41, 253-72, 1947.

Carl Cori and his wife Gerty Cori (1896-1957) shared the Nobel Prize (with Houssay) in 1947 for their researches on the course of the catalytic transformation of glycogens. They are more often remembered for the Cori cycle (see No. 12327).



Subjects: BIOCHEMISTRY › Metabolism
  • 752.3

Enzymatic synthesis and breakdown of polynucleotides; polynucleotide phosphorylase.

J. Amer. chem. Soc., 77, 3165-66, 1955.

Ochoa shared the Nobel Prize with Kornberg in 1959 for their artificial synthesis of nucleic acids by means of enzymes. The above paper describes the discovery of an enzyme able to catalyse the removal of a terminal phosphate group from ribonucleoside diphosphates.



Subjects: BIOCHEMISTRY, BIOLOGY › MOLECULAR BIOLOGY › Nucleic Acids, WOMEN, Publications by › Years 1900 - 1999
  • 752.4

Enzymic synthesis of deoxyribonucleic acid.

Biochim. Biophys. Acta., 21, 197-98, 1956.

With I. R. Lehman, M. J. Bessman, and E. S. Simms. Komberg shared the Nobel Prize with Ochoa in 1959.



Subjects: BIOCHEMISTRY, BIOLOGY › MOLECULAR BIOLOGY › Nucleic Acids
  • 752.5

The nature and mode of action of oxidation enzymes. Nobel Lecture, December 12, 1955. In: Festschrift Arthur Stoll, pp. 35-47.

Basel: Birkhäuser, 1957.

Theorell was awarded a Nobel Prize in 1955 for his discoveries relating to the nature and mode of action of oxidizing enzymes. The above paper summarizes his work in this field.



Subjects: BIOCHEMISTRY
  • 752.6

Studies on polynucleotides. I. A new and general method for the chemical synthesis of the C5'-C3' intemucleotide linkage. Synthesis of deoxyribo-dinucleotides.

J. Amer. chem. Soc., 80, 6212-22, 1958.

Khorana shared the Nobel Prize (Physiology) with R. W. Holley and M. W. Nirenberg in 1968 for the techniques he established for the synthesis of polynucleotides. H. G. Khorana, T. M. Jacob, and S. Nishimura were principally responsible for producing evidence confirming the genetic code.



Subjects: BIOCHEMISTRY, BIOLOGY › MOLECULAR BIOLOGY › Genetic Code, BIOLOGY › MOLECULAR BIOLOGY › Nucleic Acids
  • 752.7

Cyclic AMP.

Ann. Rev. Biochem., 37, 149-74, 1968.

Sutherland elucidated the role of cyclic adenosine monophosphate, the second messenger mediating actions in a wide range of hormonal effects. He received the Nobel Prize in 1971.



Subjects: BIOCHEMISTRY
  • 753

Ibn an Nafis und seine Theorie des Lungenkreislaufs.

Quell. Stud. Gesch. Med., 4, 37-88, 1935.

Ibn-al-Nafis, a Syrian physician, described the lesser circulation in his commentary on the anatomy of the Canon of Avicenna, 1268. This was discovered in three Arabic MSS by Mohyi el Din el Tatawi, who included a German translation in his inaugural dissertation, Der Lungenkreislauf nach el-Koraschi, Freiburg, 1924. According to E. J. Brill's First Encyclopaedia of Islam (1913-1936) p. 95, this dissertation was issued in only 5 manuscript copies. Meyerhof included 29 pages of Arabic text in the above paper, which appears to represent the first appearance of the relevant Arabic text of Ibn-al-Nafis in print. English translations are in Ann. Surg., 1936, 104, 1-8, and in Bull. med. Hist., 1955, 29, 430-40. See John B. West, "Ibn al-Nafis, the pulmonary circulation, and the Islamic Golden Age," J Appl Physiol (1985). 2008 Dec; 105(6): 1877–1880.



 


Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System, CARDIOLOGY › History of Cardiology, ISLAMIC OR ARAB MEDICINE › History of Islamic or Arab Medicine, MEDIEVAL MEDICINE › History of Medieval Medicine, PHYSIOLOGY › History of Physiology
  • 754

Christianismi restitutio.

Vienne, France: Balthasar Amoullet, 1553.

Contains (pp. 168-73) the first printed description of the lesser circulation. Because of the heretical nature of this book on the reform of Christianity, it was printed secretly and anonymously at Vienne, France. Copies had circulated in manuscript as early as 1546.

As a punishment for heresy, Servetus, a physician, was burnt at the stake at Champel, Geneva, by order of Calvin, soon after publication. Virtually the entire edition of 1000 copies was burned with him. Only three copies survive: Richard Mead’s copy in the Bibliothèque nationale de France, a copy in the Imperial Library, Vienna, and a copy lacking the title page and the first 16pp., said to be Calvin’s personal copy, at Edinburgh University Library.

Servetus's passage on the lesser circulation was first reprinted by William Wotton in Reflections upon ancient and modern learning (1694), pp. 211-12. Wotton provided the Latin text on pp. 230-31 of the second edition of Reflexions.... (1697), and in an added "Postscript" that prefixed the second edition he provided the first English translation on pp. xxvi-xxxii. Interestingly, Wotton printed Servetus's text from a transcription provided to him by Charles Bernard; neither Wotton nor Bernard were able to view a copy of the actual book from which it had been copied.

Servetus's complete work was reprinted in type facsimile in 1790 at Nuremberg. Servetus’s passages describing the pulmonary circulation are also translated in J. F. Fulton’s Selected readings in the history of physiology, 2nd ed., 1966, pp. 44-45. See Fulton & Stanton, Michael Servetus, humanist and martyr. With a bibliography of his works, New York: Reichner, 1953.

Digital facsimile of the 1694 edition of Wotton from the Internet Archive at this link. Digital facsimile of the 1697 edition of Wotton at this link. Digital facsimile of the 1790 facsimile from Google Books at this link.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System
  • 755

Peripateticarum quaestionum libri quinque.

Venice: apud Iuntas, 1571.

Cesalpino preceded Harvey in the discovery of the concept of the circulation, and Harvey must have known of his ideas, but Cesalpino’s idea of the circulation was not supported by convincing experimental work or quantitative evidence.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System
  • 756

Quaestionum peripateticum, libri V.

Venice: apud Juntas, 1593.

A greatly expanded second edition. The results of tying a vein and the centripetal flow in veins were first recorded in print by Cesalpino (lib. ii, Qu. xvii, p. 234). See the English translation, with commentary, of the portions of this work relevant to the circulation by Clark, Nimis and Rochefort in J. hist. med. & all. sci., 1978, 33, 185-213.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System
  • 757

De venarum ostiolis.

Padua: L. Pasquati, 1603.

Fabricius, teacher of Harvey at Padua, discovered the venous valves, and illustrated them in life-size copperplates in this monograph. He failed to recognize their true function, however, considering this to be merely a delaying of the blood flow. This work must have influenced Harvey to turn his experimental efforts toward an accurate explanation for the existence of the venous valves. This line of research eventually led him to develop an accurate knowledge of how the circulation worked. Facsimile edition, with English translation, edited by K. J. Franklin, 1933.



Subjects: ANATOMY › 17th Century, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Anatomy of the Heart & Circulatory System, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System
  • 758

Praelectiones anatomiae universalis.

London: John Churchill, 1886.

Facsimile reproduction with transliteration of Harvey’s manuscript notes for a Lumleian Lecture, 1616. These show that at that date Harvey had already completed his demonstration of the circulation of the blood. English translation with annotations, Berkeley, 1961. Edited, with an introduction, translation, and notes by G. Whitteridge, Edinburgh, 1964.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System
  • 759

Exercitatio anatomica de motu cordis et sanguinis in animalibus.

Frankfurt: sumpt. Guilielmi Fitzeri, 1628.

Discovery and experimental proof of the circulation of the blood. Together with Vesalius’s Fabrica (1543), Harvey’s De motu cordus shares the honor as the greatest book in the history of medicine. Since antiquity, ideas about the physiology and pathology of most parts of the body had been based to an important degree on assumptions made about the function of the heart and blood vessels. In fundamentally changing the conception of these functions, Harvey pointed the way to reform of all of physiology and medicine.

Why Harvey chose a European publisher for his book has long provoked speculation— the most plausible conjecture is that Harvey wanted his book published on the Continent so that it would more easily gain international distribution and acceptance. His choice of the Frankfurt publisher William Fitzer seems to have arisen from his long acquaintance with Robert Fludd, whose books were then being published by Fitzer.The physical distance between Harvey and his publisher seems to have precluded Harvey from correcting proofs, as he was compelled to issue an errata leaf with no less than 126 corrections. Since very few copies of De motu cordis include this errata leaf, it has been argued that it was probably added after a large portion of the edition had already been sold. Even so, Harvey's errata list must have been compiled with some haste, as the Latin text edited by Akenside for the College of Physicians in 1766 contains 246 emendations. Fitzer had Harvey's book printed on paper of poor quality, which has deteriorated in virtually all surviving copies. The first edition must have been relatively small since only about 68 copies have survived, nearly all in institutions. Reprinted in facsimile in 1928 (Monumenta medica, Vol. 5, Florence). The Latin text, with an English translation by K. J. Franklin, was published in Oxford, 1957, and a translation with introduction and notes was published by G. Whitteridge in 1976 (Oxford, Blackwell). See also No. 6l.l.  Digital facsimile from The Warnock Library at this link.

 



Subjects: CARDIOLOGY, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System, PHYSIOLOGY
  • 760
  • 915

De pulmonibus observations anatomicae.

Bologna: B. Ferronius, 1661.

Discovery of the capillary circulation. Malpighi demonstrated that the pulmonary tissues are vesicular in nature and showed that the trachea ends in bronchial filaments. His De pulmonibus includes his demonstration of the capillary anastomosis between arteries and veins. This book, which is very rare, consists of two letters to Borelli describing observations made through the microscope on the lung of a living frog. In the second letter Malpighi described small channels connecting arteries with veins, the capillaries. This was the first proof that blood circulation occurred within a closed hydraulic system. The second edition was published as an appendix to Thomas Bartholin’s De pulmonum substantia et motu diatribe, 1663. It is republished in his Opera omnia, Lugduni Batavorum, 1687, ii, 331. A facsimile was published in Milan in 1958; English translation by J. Young in Proc. roy. Soc. Med., 1929-30, Sect. Hist. Med., 23, 1-11. See No. 915



Subjects: ANATOMY › 17th Century, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Anatomy of the Heart & Circulatory System, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System, MICROBIOLOGY, RESPIRATION
  • 761

Tractatus de corde.

London: J. Allestry, 1669.

Lower was the first to demonstrate the scroll-like structure of the cardiac muscle. He was one of the first to transfuse blood. Chapter III of the above work records how Lower injected dark venous blood into the insufflated lungs; he concluded that its subsequent bright red color was due to its absorption of some of the air passing though the lungs. The British Museum copy of this book bears the signature of Walter Charleton, followed by the date “1668”; it is possible, therefore, that the book actually appeared in that year and not in 1669. Facsimile, with translation, London, 1932.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Anatomy of the Heart & Circulatory System, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System
  • 3669.3
  • 762

De motu animalium. 2 pts.

Rome: A. Bemabo, 16801681.

Borelli originated the neurogenic theory of the heart’s action and first suggested that the circulation resembled a simple hydraulic system. He was the first to insist that the heart beat was a simple muscular contraction. One of the founders of biomechanics, Borelli was a representative of the Iatro-Mathematical School, which treated all physiological happenings as rigid consequences of the laws of physics and mechanics.

Borelli’s experiments included what are probably the first measurements of masticatory force.

English translation by P. Maquet from the 1743 edition as On the movement of animalsBerlin: Springer, 1989. 

Digital facsimile of the 1743 edition from the Internet Archive at this link.



Subjects: Biomechanics, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System, DENTISTRY, Iatrophysics
  • 4162
  • 762.1

De urinis et pulsibus de missione sanguinis de febribus de morbis capitis, et pectoris.

Bologna: Ex typographia Antonii Pisarii, 1683.

Bellini began to develop his hydraulic iatromechanics in this work, in which he considered the blood as a physical fluid with simple mechanical and mathematicizable properties.  He realized the value of the urine as an aid to diagnosis and insisted on its chemical analysis in pathological conditions.



Subjects: BIOCHEMISTRY, Biomechanics, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, Iatrophysics, UROLOGY
  • 763

Disputatio medica inauguralis de circulo sanguinis in corde.

Leiden: A. Elzevier, 1708.

First description of the coronary valves and the venae thebesii.



Subjects: ANATOMY › 18th Century, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Anatomy of the Heart & Circulatory System
  • 764

Mémoire dans lequel il est démontré que les nerfs intercostaux fournissent des rameaux que portent des espirits dans les yeux.

Hist. Acad. roy. Sci. (Paris) (Mém), 1-19., 1727.

Discovery of the vasomotor nerves (see also No. 1313).



Subjects: ANATOMY › Neuroanatomy
  • 765

Vegetable staticks: Or, an account of some statical experiments on the sap in vegetables. Statical essays, containing haemastaticks. 2 vols.

London: W. Innys & R. Manby, 17271733.

Hales initiated a new stage in physiological experimentation with his "statical" methods, which were characterized by precise quantitative measurements, repetition and the used of controls, and were based on the assumption that that the known laws of matter operated in the bodies of plants and animals as well as in non-living materials. In his investigations of plant physiology, described in Vegetable Staticks, Hales studied the movement of water in plants, determining that leaf suction is the main force by which water is raised through a plant, and showing that plants lose water constantly via transpiration through their leaves. He also demonstrated that plants do not have a true circulation, and developed techniques to measure the varying rates of growth in different plant structures.

Vegetable Staticks is the first volume of Hales's Statical Essays, the second volume of which (Haemastaticks) appeared in 1733. Haemastaticks ecords Hales' invention of the manometer, with which he was the first to measure blood-pressure. His work is the greatest single contribution to our knowledge of the vascular system after Harvey, and led to the development of the blood-pressure measuring instruments now in universal use.

In the course of his work Hales indirectly discovered vasodilatation and vasoconstriction. Concluding that the force of the arterial blood in the capillaries could not be sufficient to produce muscular motion, he suggested a force regulated by the nerves, and perhaps electrical. "Hales was therefore the first physiologist to suggest, with some evidence to support it, the role of electricity in neuromuscular phenomena" (Dictionary of Scientific Biography). Digital facsimile from the Biodiversity Heritage Library at this link.

 



Subjects: BOTANY, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System, INSTRUMENTS & TECHNOLOGIES › Medical Instruments, PHYSIOLOGY
  • 765.1

Dissertationem inauguralem de vera nervi intercostalis origine.

Gottingen: Abram Vandenhoeck, 1743.

Taube described the carotid body and named it “ganglion minutum”, See J. Pick, J. Hist. Med., 1959, 14, 61-73.



Subjects: ANATOMY › 18th Century, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System
  • 765.2

An inquiry into the causes of the motion of the blood; with an appendix, in which the process of respiration and its connexion with the circulation of the blood are attempted to be elucidated.

Liverpool: Longman, 1815.

Carson recognized the vital effect on venous return played by the negative pressure in the pleural cavity.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY
  • 766

Wellenlehre auf Experimente gegründet oder über die Wellen tropfbarer Flüssigkeiten mit Anwendung auf die Schall- und Lichtwellen.

Leipzig: Gerhard Fleischer, 1825.

The first work to apply hydrodynamics to the circulation of the blood.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY
  • 767

Recherches sur la force du coeur aortique.

Paris: De L'Imprimerie de Didot le jeune, 1828.

Poiseuille was the first after Stephen Hales to make any important addition to the knowledge of the physiology of circulation. In his graduation thesis, above, he described a “hemodynamometer” invented by himself and which he used to repeat some of Hales’s blood-pressure experiments. With his hemomanometer, a mercury manometer, which was a great improvement on the long tube used by Hales, Poiseuille showed that the blood-pressure rises and falls on expiration and inspiration, and measured the degree of arterial dilatation produced by each heart beat. English translation in Edinb. med. surg. J., 1829, 32, 28-38. See also his paper in J. Physiol. exp. path., 1828, 8, 272-305. Digital facsimile from the Internet Archive at this link.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, INSTRUMENTS & TECHNOLOGIES › Medical Instruments
  • 768

Recherches expèrimentales sur le mouvement des liquides dans les tubes de très petits diamètres.

C. R. Acad. Sci. (Paris), 11, 961-67, 1041-48; 12, 112-15, 1840, 1841.

Poiseuille’s law of the flow of liquids in tubes – fundamental in blood viscosimetry. Abstract; complete monograph in Mém. Acad. roy. Sci. (Paris), 1846, 9, 433-544. First book-form edition, Paris, 1844.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY
  • 768.1

A critical and experimental essay on the circulation of the blood.

London: R. B. Seeley & W. Burnside, 1831.

Marshall Hall clearly distinguished arterioles and venules from capillaries, and he described arteriovenous shunts.



Subjects: ANATOMY › 19th Century, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Anatomy of the Heart & Circulatory System, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System
  • 543
  • 769

Allgemeine Anatomie. Lehre von den Mischungs- und Formbestandtheilen des menschlichen Körpers.

Leipzig: Leopold Voss, 1841.

Many of the histological discoveries of Henle are described in the above. He classified tissues histologically. In the section on Gefässnerven (pp. 510, 690) Henle demonstrated the presence of smooth muscle in the endothelial coat of small arteries. Digital facsimile from the Hathi Trust at this link.

 

 



Subjects: ANATOMY › 19th Century, ANATOMY › Microscopic Anatomy (Histology), CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Anatomy of the Heart & Circulatory System
  • 770

Beiträge zur Kenntniss des Einflusses der Respirationsbewegungen auf den Blutlauf im Aortensystem.

Arch. Anat. Physiol. wiss. Med., 242-302, 1847.

Ludwig changed Poiseuille’s hemodynamometer into the kymograph by the addition of a float and caused this float to write on a recording cylinder. Abridged English translation in Ruskin (No. 3160.1).



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, INSTRUMENTS & TECHNOLOGIES
  • 771

Die Hämodynamik nach Versuchen.

Leipzig: Breitkopf & Härtel, 1850.


Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System
  • 2759
  • 772

Die bildliche Darstellung des menschlichen Arterienpulses.

Arch. physiol. Heilk., 13, 284-87, 1854.

Vierordt invented a sphygmograph which acted on the principle that indirect estimation of blood-pressure could be accomplished by measuring the counter-pressure necessary to obliterate the arterial pulsation. This was the first instrument with which a tracing of the human pulse could be made. The paper is the first record of a study with an instrument of precision of the pulse in health and disease. Vierordt expanded this work into book form: Die Lehre von Arterienpuls, Braunschweig, Vieweg, 1855.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, CARDIOLOGY › Tests for Heart & Circulatory Function › Sphygmogram, INSTRUMENTS & TECHNOLOGIES › Medical Instruments
  • 773

Études expérimentales sur les lésions organiques du coeur.

Ann. Soc. Méd. Lyon, 2 sér., 4, 180-88, 1856.

Faivre made the first accurate estimation of the blood-pressure in man, by connecting the artery with a mercury manometer and making direct readings. These investigations were important, since they established normal values. The paper was republished in book form in 1856. English translation of part 2 in Ruskin (No. 3160.1).



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, INSTRUMENTS & TECHNOLOGIES
  • 774

De l’influence de deux ordres de nerfs qui déterminent les variations de couleur du sang veineux dans les organes glondulaires.

C. R. Acad. Sci., (Paris), 47, 245-53; 393-400, 1858.

Discovery of the vasoconstrictor and vasodilator nerves and description of their function of regulating the blood supply to the different parts of the body.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System, NEUROSCIENCE › Neurophysiology
  • 775

Die Erscheinungen und Gesetze der Stromgeschwindigkeiten des Blutes.

Frankfurt: Meidinger Sohn & Co., 1858.

Vierordt estimated, by means of a “hemotachometer” of his own invention, the rate of the blood flow in various arteries, and also the influence of the blood volume, pulse rate and respiratory rate upon it.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, INSTRUMENTS & TECHNOLOGIES
  • 776

Recherches sur le pouls au moyen d’un nouvel appareil enregistreur le sphygmographe.

Paris: E. Thunot et Cie, 1860.

Invention of the modern sphygmograph. Also published in C.R. Acad. Sci. (Paris), 1860, 51, 281-309. Preliminary paper in same journal, 1860, 50, 634-37.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, CARDIOLOGY › Tests for Heart & Circulatory Function › Sphygmogram, INSTRUMENTS & TECHNOLOGIES
  • 777

Sur la pression du sang dans le système artériel.

C. R. Acad. Sci. (Paris), 51, 238-42, 1860.


Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY
  • 778

Die physiologischen Leistungen des Blutdrucks.

Leipzig: S. Hirzel, 1865.

Ludwig’s inaugural address at Leipzig, in which he introduced the idea of keeping alive excised portions of organs by means of artificial circulation, or perfusion. He suggested that the blood-pressure had a stimulating effect on the vagus.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY
  • 779

Die Ausmessung der strömenden Blutvolumina.

Arb. physiol. Anst. Lpz. (1867), 2, 196-271, 1868.

Invention of the Stromuhr, for measurement of the velocity of the blood. Dogiel was a pupil of Ludwig.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, INSTRUMENTS & TECHNOLOGIES
  • 780

Die beiderseitige mechanische Reizung des Nv. vagus beim Menschen.

Zbl. med. Wiss., 13, 403-06, 1875.


Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY
  • 781

Ueber den Druck in den Blutcapillaren der menschlichen Haut.

Arb. physiol. Anst. Lpz. (1875), 10, 69-80, 1876.

Kries attempted to measure blood pressure in the capillaries by using a skin blanching method.



Subjects: CARDIOLOGY › CARDIOVASCULAR DISEASE › Hypertension (High Blood Pressure), CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, DERMATOLOGY
  • 782

Untersuchungen über die Gefässernerven-Wurzeln des Ischiadicus.

S. B. k. Akad. Wiss. Wien, math.-nat. Cl., 3 Abt., 74, 173-85, 1876.

Stricker was the first to describe vasodilatation on stimulation of the posterior nerve roots.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, NEUROSCIENCE › Neurophysiology
  • 782.1

Sur la contractilité capillaires sanguins.

C. R. Acad. Sci. (Paris), 88, 916-18, 1879.

Rouget made an important investigation of the control of capillary circulation. He described cells (“Rouget’s cells”) on the outer surfaces of capillary walls, considered to be contractile. English translation in No. 1588.3.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Anatomy of the Heart & Circulatory System
  • 783

La circulation du sang à l’état physiologique et dans les maladies.

Paris: G. Masson, 1881.


Subjects: CARDIOLOGY › CARDIOVASCULAR DISEASE, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY
  • 784

Das Venensystem des menschlichen Körpers. 2 pts. and atlas.

Leipzig: Veit & Co., 18841889.

Like Braune’s other anatomical works, this is notable for its excellent illustrations.



Subjects: ANATOMY › 19th Century, ANATOMY › Anatomical Illustration, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Anatomy of the Heart & Circulatory System
  • 785

Der Einfluss der Systems der Vena portae auf die Vertheilung des Blutes.

Arch. Anat. Physiol. Abt., 409-53, 1892.

Translated into English as "The contraction of the vena portae and its influence upon the circulation," Johns Hopkins Hospital Reports, I (1896) 111-157. Digital facsimile of the English translation from Google Books at this link.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Anatomy of the Heart & Circulatory System, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System
  • 786

On the results of ligation of the coronary arteries.

J. Physiol. (Lond.), 15, 121-38, 1893.

“Following coronary ligation Porter noted that the procedure frequently resulted in fibrillary contractions of the heart and sudden death. However, death did not always occur and this led him to conclude that Cohnheim’s (1881) consistently fatal results were due to operative trauma and that the coronary arteries were not end arteries” (Willius & Dry).
Digital facsimile from PubMedCentral at this link.

Continued with his "Further researches on the closure of the coronary arteries," J. exp. Med., 1 (1896) 46-70. Digital facsimile from PubMedCentral at this link.



Subjects: CARDIOLOGY › CARDIOVASCULAR DISEASE › Coronary Artery Disease, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System
  • 787

Lehrbuch der Physiologie des Kreislaufes.

Leipzig: Veit & Co., 1893.


Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY
  • 788

The significance of a hitherto undescribed wave in the jugular pulse.

Lancet, 2, 1380-82, 1907.

The physiological wave sometimes found in mid-diastole, when the pulse is slow, was first described by Gibson. He termed it the b-wave.
Gibson worked with William Osler at the Radcliffe Infirmary in Oxford, and cared for the Regius Professor during his last illness. Gibson also performed Osler's autopsy.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiac Electrophysiology
  • 789

Some considerations upon high amputation of the rectum.

Ann. Surg., 50, 1091-94, 1909.

“Hartmann’s critical point”, the site on the large intestine where the lowest sigmoid artery meets the superior rectal arterial branch.



Subjects: SURGERY: General
  • 790

The blood-vessels in the arterioles, capillaries and small veins of the human skin.

Amer. J. Physiol, 29, 335-62, 19111912.

Lombard soaked the skin in cedarwood oil, rendering transparent the superficial epidermal layers, and thus making possible many direct observations on it.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Anatomy of the Heart & Circulatory System, DERMATOLOGY
  • 791

The blood pressure fall produced by traction on the carotid artery.

Amer. J. Physiol., 30, 88-104, 1912.

First description of the carotid sinus depressor reflex.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY
  • 792

The vasodilator action of histamine and of some other substances.

J. Physiol. (Lond.), 52, 110-65, 19181919.

Dale and Richards studied the effect of histamine on the control of the circulation and showed its peripheral action to be located in the capillaries and smaller arterioles.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System
  • 793

The anatomy and physiology of the capillaries.

New Haven, CT: Yale University Press, 1922.

Silliman Lectures. A second edition appeared in 1929. Krogh received the Nobel Prize for Physiology in 1920. His most important work was on the physiology of capillaries.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY
  • 794

Der Karotisdruckversuch.

Münch med. Wschr., 70, 1287-90, 1923.


Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System
  • 795

Die Aenderung der Herzschlagzahl durch Aenderung des arteriellen Blutdruckes erfolgt aus reflektorischem Wege; gleichzeitig eine Mitteilung über die Funktion des Sinus caroticus, beziehungsweise der Sinusnerven.

Pflüg. Arch. ges. Physiol., 206, 721-3, 1924.

First description of the structure and function of the sinus nerve and the reflex character of carotid pressure.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY › Cardiovascular System, NEUROSCIENCE › Neurophysiology
  • 795.1

The capillary pressure in frog mesentery as determined by micro-injection methods.

Amer. J. Physiol., 75, 548-70, 1926.

Direct measurement of the blood pressure within the capillaries.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY
  • 796

Studies in the velocity of blood flow.

J. Clin. Invest., 4, 1-13, 15-31, 149-71, 173-97, 199-209, 389-425, 555-74, 19261927.

First practical method of measuring circulation time. 

"In 1925, Hermann Blumgart performed the first diagnostic procedure using radioactive indicators on humans; this first is well recognized. Less well recognized is the fact that Blumgart and his coworker Otto C. Yens, then a medical student, developed the first instrumentation used in a diagnostic procedure involving radioactive indicators. The instrumentation, a modified Wilson cloud chamber, turned out to be the detector most suitable for their purpose. Blumgart also showed remarkable foresight in outlining the requirements both for a satisfactory indicator (tracer) and for a satisfactory detector—requirements that still hold true today. The Blumgart–Yens modified cloud chamber was the birth of nuclear medicine instrumentation" (http://jnm.snmjournals.org/content/44/8/1362.long, accessed 03-2018).

 

Digital facsimile of most of the papers in this series are available from PubMedCentral.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, Nuclear Medicine
  • 797

The blood-vessels of the human skin and their responses.

London: Shaw, 1927.


Subjects: ALLERGY, CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, DERMATOLOGY
  • 798

Die Thermo-Stromuhr. Ein Verfahren zur fortlaufenden Messung der mittleren absoluten Durchfulssmengen in uneröffneten Gefässen in situ.

Z. Biol, 87, 394-418, 1928.

Introduction of the Thermostromuhr, an instrument for measuring the velocity of the blood flow.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, INSTRUMENTS & TECHNOLOGIES
  • 799

The pressure pulses in the cardiovascular system.

London: Longmans, Green & Co., 1928.

Wiggers, professor of physiology at the Western Reserve University, Cleveland, contributed much to the knowledge of the circulation and devised several instruments to promote the study of this subject.



Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, INSTRUMENTS & TECHNOLOGIES