An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16018 entries, 14076 authors and 1941 subjects. Updated: July 14, 2024

Browse by Entry Number 3800–3899

107 entries
  • 3800

Oestrogenic activity of alkylated stilboestrols.

Nature (Lond.), 142, 34, 1938.

Introduction of dienoestrol. With L. Gol[d]berg, W. Lawson.

  • 3801

Oestrogenic activity of anol; a highly active phenol isolated from the byproducts.

Nature (Lond.) , 142, 1121, 1938.

Isolation of hexoestrol. With E. C. Dodds and W. Lawson.

  • 3801.1

A syndrome of infantilism, congenital webbed neck, and cubitus valgus.

Endocrinology, 23, 566-74, 1938.

“Turner’s syndrome”.

  • 3802

The endocrine glands

New York: Appleton-Century, 1939.

Goldzieher dealt very fully with the history, theory, and practice of endocrinology.

Subjects: ENDOCRINOLOGY, ENDOCRINOLOGY › History of Endocrinology
  • 3803

Clinical use of triphenylchlorethylene.

Lancet, 2, 1362-66, 1939.

  • 3804

Syndrome characterized by gynecomastia, aspermatogenesis without A-Leydigism, and increased excretion of follicle-stimulating hormone.

J. clin. Endocr., 2, 615-27, 1942.

Klinefelter syndrome. With E. C. Reifenstein and F. Albright.

  • 3805

De generatione stultorum. In his Opera, 2, 174-82.

Strassburg, Austria, 1603.

Paracelsus was the first to note the coincidence of cretinism and endemic goitre. It was not until the 19th century that the possibility of the occurrence of cretinism in adults was entertained. Partial English translation in No. 2241

Subjects: ENDOCRINOLOGY › Thyroid
  • 3806

De mirabili strumas sanandi.

Paris: M. Orry, 1609.

An early historical record of goitre which du Laurens maintained was contagious. Du Laurens was at one time physician to Henri IV.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3807

An account and method of cure of the bronchocele or Derby neck.

London: W. Owen, 1769.

Prosser gave the prescription of a powder containing calcined sponge, to be taken for the cure of goitre. This is probably the first recorded use of an iodine preparation in England.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3808

Cases and remarks in surgery: to which is subjoined an appendix containing the method of curing the bronchocele in Coventry.

London: T. Longman, 1779.

The “Coventry treatment” for goitre, which introduced the burnt sponge remedy into England, is mentioned on pp. 249-54. Digital facsimile from the Hathitrust at this link.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3809

Su i gozzi e sulla stupidità che in alcuni paesi gli accompagna tentativi

Torino: Dalla Stamperia Reale, 1789.

Hirsch considered this the first important work on cretinism and goitre. See also Malacarne’s Lettre, in J. P. Frank: Delectus opusculorum medicorum, 1789, 6, 241-58. Digital facsimile of Malacarne's pamphlet from Google Books at this link.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3810

Essai sur le goitre et le crétinage. Où l'on recherche particulièrement quelles son les causes de ces deux maladies des habitans des vallées, et quels sont les moyens physiques et moraux qu'il convient d'employer pour s'en préserver entièrement à l'avenir.

Turin: De l'Imprimerie Royale, 1792.

Fodéré considered cretinism to be due to the concentrated air in deep valleys, rather than to water. He also drew attention to the skeletal changes. Digital facsimile from Google Books at this link

Subjects: ENDOCRINOLOGY › Thyroid
  • 3811

Sopra un tumor freddo nell’anterior parte del collo detto broncocele.

In his Collezione d’osservazione e riflessioni di chirurgia, Roma , 3, 270-73, 1802.

One of the earliest accounts of exophthalmic goitre. The author noted cardiac disturbances in thyroid enlargement.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3812

Découverte d’un nouveau remède contre le goitre.

Bibliothèque universelle, 14, 190-98; also in Ann. Chim. Phys., 15, 49-59, 1820, 1820.

Coindet is usually regarded as the first to administer iodine in cases of goitre, with beneficial results. It had previously been prepared from seaweed by B. Courtois in 1812 (Ann. Chim. (Paris), 1813, 88, 304-10), and both Ampère and Humphry Davy were interested in it. W. Prout, however, in his Chemistry, meteorology, etc., London, 1834, p. 113, claimed that he had recommended it to John Elliotson, who had used it in 1819 at St. Thomas’s Hospital. There is an English translation of his paper in Lond. med. Phys. J., 1820, 44, 486-89.

Subjects: ENDOCRINOLOGY › Thyroid
  • 2210
  • 3813
  • 4522

Collections from the unpublished writings of the late Caleb Hillier Parry. 3 vols.

London: Underwoods , 1825.

Includes Parry’s interesting description of eight cases of exophthalmic goitre, the first of which was observed in 1786, and his notes on four cases of angina pectoris. Parry's paper, "Enlargement of the thyroid gland in connection with enlargement or palpitation of the heart," appears in vol. 2, pp. 111-129. This is classic account of exophthalmic goitre. Although Graves and Basedow have both been credited with the first description of the condition, giving their names to it, Osler called attention to the priority of Parry’s claim, and it is now sometimes referred to as “Parry’s disease”. Garrison says that Parry first noted the condition in 1786; he briefly reported it in his Elements of pathology and therapeutics, 1815. Reprinted in Med. Classics, 1940, 5, 8-30. See No. 2210.

Parry was a copious note-taker, and many of these notes are here published for the first time. His careful records of many years’ observation in practice were intended to form a large work, Elements of pathology and therapeutics, of which only the first volume appeared, in 1815; this was republished, together with the unfinished vol. 2, in 1825. In vol. 1, pp. 478-80 Parry was the first to record cases of facial hemiatrophy.

This posthumous work was seen through the press by Parry's son, the physician and writer Charles Henry Parry, who added the following supplementary volume, which is not always noticed: Introductory Essays to Collections from the unpublished Medical Writings of the late Caleb Hillier Parry, M.D.,  also published in 1825. 

Subjects: CARDIOLOGY, CARDIOLOGY › CARDIOVASCULAR DISEASE › Coronary Artery Disease › Angina Pectoris, ENDOCRINOLOGY › Thyroid , NEUROLOGY › Diseases of the Nervous System
  • 3814

Removal of the right lobe of the thyroid gland.

Lancet, 2, 351-52, 18281829.

To Joseph Green, of St. Thomas’s Hospital, London, is accredited the first thyroidectomy, the patient succumbing 15 days later from sepsis.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3815

Palpitation of the heart with enlargement of the thyroid gland.

Lond. med. surg. J. (Renshaw), 7, 516-17, 1835.

This is considered the first accurate account of exophthalmic goitre, later known as “Parry’s disease”, “Graves’s disease”, and “Basedow’s disease”. An interesting fact about the London Medical & Surgical Journal is that after the first five volumes had been published by Renshaw and edited by M. Ryan, these two separated, each continuing to publish a separate edition of the same journal. Graves’s paper appeared in the series published by Renshaw. Reprinted in Med. Classics, 1940, 5, 33-36.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3816

Exophthalmos durch Hypertrophie des Zellgewebes in der Augenhöhle.

Wschr. ges. Heilk., 6, 197-204, 220-28, 1840.

In Europe, outside the British Isles, exophthalmic goitre, or Graves’s disease, is known as “Basedow’s disease”. His accurate description of four cases in which he described exophthalmos, goitre and palpitation led to the phrase “Merseburg triad”, associating these conditions with the name of his own town. He also mentioned emaciation, excessive perspiration, and nervousness as additional symptoms and anticipated later methods of treatment by his advocacy of mineral waters containing iodide and bromide of sodium. Partial English translation in No. 2241.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3817

Existence de l’iode dans les plantes d’eau douce. Conséquences de ce fait pour la géognosie, la physiologie végétale, la thérapeutique et peut-être pour l’industrie.

C. R. Acad. Sci. (Paris), 30, 352-54, 1850.

Chatin was the first to show that iodine could prevent endemic goitre and cretinism.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3818

Two cases of absence of the thyroid body and symmetrical swellings of fat tissue at the sides of the neck, connected with defective cerebral development.

Med.-chir. Trans., 33, 303-06, 1850.

Curling, of the London Hospital, was the first accurately to note the clinical picture of cretinism, which Ord was later to name “myxedema”. Curling was also the first to suggest deficiency of the thyroid as a case of cretinism.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3819

Untersuchungen über die Zuckerbildung in der Leber und den Einfluss des Nervensystems auf die Erzeugung des Diabetes.

Würzburg: Stahel, 1859.

Schiff’s reports on his experimental thyroidectomies, which were attended with fatal results. Subsequently (Arch. exp. Path. Pharmak., 1884, 18, 25) he showed that intra-abdominal transplantation of the gland would obviate fatal results in thyroidectomy.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3820

Ueber Basedow’sche Krankheit.

Dtsch. Klinik, 16, 158-59, 1864.

“Graefe’s sign” – the discovery by von Graefe of the failure of the eyelid to follow the eye when it is rolled downward – diagnostic of exophthalmic goitre. Partial English translation in No. 2241.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3821

Ueber die totale Exstirpation einer kropfig entarteten Schilddrüse, und über die Rückwirkung dieser Operation auf die Circulationsverhältnisse im Kopfe.

Med. CorrespBl. württemb. ärztl. Vereins, 37, 199-205, 1867.

Sick is credited with being the first to notice symptoms of loss of thyroid function following thyroidectomy. According to Halsted, the above is the first report of total thyroidectomy and “the first report of the condition which we now recognize as status thyreoprivus”.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3822

On sporadic cretinism.

Med.-chir. Trans., 54, 155-70, 1871.

In this paper Fagge, nephew of John Hilton of Guy’s Hospital, described sporadic cretinism as distinct from the endemic variety.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3823

On a cretinoid state supervening in adult life in women.

Trans. clin. Soc. Lond., 7, 180-85, 18731874.

Gull was among the first to point out the cause of myxedema, of which the above paper gives a classic description. Gull was associated with Guy’s Hospital, London, for most of his life.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3824

Excision of the thyroid gland.

Edinb. med. J., 19, 252-55, 1874.

Watson was a pioneer of thyroidectomy in the treatment of goitre, although Green (No. 3814) was the first to perform the operation. Also in Brit. med. J., 1875, 2, 386-88.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3825

On myxoedema.

Med.-chir. Trans., 61, 57-78, 1878.

Ord coined the term “myxedema” for the condition noted earlier by Curling and Gull.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3826

Exstirpation einer Struma retroesophagea.

KorrespBl. Schweiz. Aerzte, 8, 702-05, 1878.

Kocher, a pupil of Billroth, was a pioneer of thyroidectomy for goitre. Before his time the operation was seldom performed. Garrison says that Kocher performed this difficult operation 2,000 times, with a mortality rate of only 4.5 per cent.

In 1909 Kocher was awarded the Nobel Prize in Physiology or Medicine "for his work in the physiology, pathology and surgery of the thyroid."

Subjects: ENDOCRINOLOGY › Thyroid , NOBEL PRIZES › Nobel Prize in Physiology or Medicine
  • 3827

Ueber Kropfexstirpation und ihre Folgen.

Arch. klin. Chir., 29, 254-337, 1883.

Kocher coined the term “cachexia strumipriva” to describe the myxedema following total extirpation of the thyroid. His work on the subject led to a better understanding of the cause of myxedema.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3828

Accidents consécutifs à l’ablation totale du goitre.

Rev. méd. Suisse rom., 2, 539, 1882.

Reverdin produced myxedema by removal of the thyroid as a whole or in part. This confirmed the earlier work of Schiff, of which Reverdin had probably not heard. See also No. 3836.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3829

Note sur vingt-deux opérations de goitre.

Rev. méd. Suisse rom., 3, 169-98, 233-78, 309-64, 1883.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3830

Sur la nature et sur quelques-uns des symptomes de la maladie de Basedow.

Arch. Neurol. (Paris), 6, 79-85, 1883.

The fourth cardinal sign in exophthalmic goitre – tremor – was first mentioned by Pierre Marie.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3831

A typical case of myxoedema.

Brit. med. J., 2, 1072, 1883.

Semon argued that cachexia strumipriva, myxedema, and cretinism were all due to loss of function of the thyroid. His contention, at first criticized, was later fully endorsed by the report of a committee set up by the Clinical Society of London to investigate the subject of myxoedema.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3832

Ueber die Entwickelung und den Bau des Kropfes.

Arch. klin. Chir., 29, 1-97, 1883.

Important classification of thyroid tumors; fetal adenoma is described on p. 40.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3833

Ueber die Exstirpation des Kropfs bei Morbus basedowii.

Berl. klin. Wschr., 21, 163-66, 1884.

First thyroidectomy for exophthalmic goitre. The operation reported was performed in 1880.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3834

A recent specimen of artificial myxoedema in a monkey.

Lancet, 2, 827, 1884.

By experimental removal of the thyroid Horsley produced artificial myxedema, confirming previous work by Reverdin and others. At the time his results were regarded as proof that total thyroidectomy produces operative myxedema, but some of the symptoms he described are now known to have been due to removal of the parathyroids.

Subjects: ENDOCRINOLOGY › Parathyroids , ENDOCRINOLOGY › Thyroid
  • 3835

Functional nervous disorders due to the loss of thyroid gland and pituitary body.

Lancet, 1, 5, 1886.

Subjects: ENDOCRINOLOGY › Pituitary, ENDOCRINOLOGY › Thyroid
  • 3836

Contribution à l’étude du myxoedème consécutif à l’extirpation totale ou partielle du corps thyroïde.

Rev. méd. Suisse rom., 7, 275-91, 318-30, 1887.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3837

Transplantation du corps thyroïde sur l’homme.

Bull. méd., 4, 225, 1890.

First thyroid transplantation (for treatment of cretinism).

  • 3838

Note on the treatment of myxoedema by hypodermic injections of an extract of the thyroid gland of a sheep.

Brit. med. J., 2, 796-97, 1891.

Murray injected thyroid extract subcutaneously in the treatment of myxedema with highly successful results.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3839

Beiträge zur Kenntniss der Basedow’schen Krankheit.

Dtsch. Arch. klin. Med., 51, 335-412, 1893.

Müller demonstrated that an increased metabolism accompanies exophthalmic goitre.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3840

Ueber den respiratorischen Gaswechsel unter dem Einfluss der Thyreoidea sowie unter verschiedenen pathologischen Zuständen.

Berl. klin. Wschr., 32, 650-52, 1895.

Magnus-Levy demonstrated the increased metabolic rate in toxic goitre, confirming the work of Müller. His experimental investigations laid the foundation for the modern conception of thyroid function. See also Z. klin. Med., 1897, 33, 269-314.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3840.1

Deaf-mutism and goitre.

Lancet, 2, 532, 1896.

Pendred syndrome, a genetic disorder leading to congenital bilateral (both sides) sensorineural hearing loss and goitre with euthyroid or mild hypothyroidism (decreased thyroid gland function). 

  • 3841

Die chronische, zur Bildung eisenharter Tumoren führende Entzündung der Schilddrüse.

Verh. dtsch. Ges. Chir., 25, 101-05, 1896.

Riedel described a type of chronic inflammation of the thyroid (“Riedel’s disease”).

Subjects: ENDOCRINOLOGY › Thyroid
  • 3842

Ueber Thyreoaplasie (kongenitales Myxoedem und infantiles Myxoedem)

Wien. klin. Wschr., 15, 1129-36, 1902.

Pineles differentiated endemic (familial) cretinism associated with goitre from sporadic cretinism.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3843

L’infantilisme vrai.

N. Iconogr. Salpêt., 20, 1-17, 1907.

Brissaud described thyroid infantilism.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3844

The relation of iodin to the structure of the thyroid gland.

Arch. intern. Med., 1, 349-84, 1908.

Marks the beginning of Marine’s lifelong study of the thyroid.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3845

Zur Kenntniss der lymphomatösen Veränderung der Schilddrüse (Struma lymphomatosa).

Arch. klin. Chir., 97, 219-48, 1912.

“Hashimoto’s disease”, struma lymphomatosa, lymphoid infiltration of the thyroid.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3846

Myxödem und Kretinismus.

Leipzig: Franz Deuticke, 1912.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3847

The pathogenesis of experimentally produced goitre.

Indian J. med. Res., 2, 183-213, 1914.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3848

Experimental hyperthyroidism.

Amer. J. Physiol., 36, 363-64, 1915.

First successful experimental production of exophthalmic goitre. With C. A. L. Binger and R. Fitz.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3849

Das Myxödemherz

Münch. med. Wschr., 65, 1180-82, 1918.

First systematic study of the characteristic changes of the heart in myxedema.

  • 3849.1

Some considerations on the operation for exophthalmic goitre.

Brit. J. Surg., 7, 195-210, 1919.

Dunhill’s operation of exophthalmic goitre is described above. He was a pioneer in thyroid surgery.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3850

Epinephrin hypersensitiveness test in the diagnosis of hyperthyroidism.

Penn. med. J., 23, 431-37, 19191920.

Goetsch devised a skin reaction test for use in the diagnosis of hyperthyroidism

Subjects: ENDOCRINOLOGY › Thyroid , Laboratory Medicine › Diagnostic Skin Tests
  • 3851

The value of iodine in exophthalmic goitre.

J. Iowa med. Soc., 14, 66-73, 1924.

Plummer and Boothby recommended the pre-operative administration of iodine in exophthalmic goitre.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3852

Diseases of the thyroid gland, with special reference to thyrotoxicosis.

London: Heinemann, 1932.

Second edition, 1951. Joll was a pioneer in the treatment of thyrotoxicosis by means of subtotal thyroidectomy.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3853

Application of radioactive iodine in therapy of Graves’s disease.

J. clin. Invest., 21, 624, 1942.

Subjects: ENDOCRINOLOGY › Thyroid , ONCOLOGY & CANCER › Radiation (Radiotherapy)
  • 3854

Treatment of hyperthyroidism with thiourea and thiouracil.

J. Amer. med. Assoc., 122, 78-81, 1943.

Astwood was the first to treat human cases of hyperthyroidism with thiourea and thiouracil.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3855

Some observations on the use of thiobarbital as an antithyroid agent in the treatment of Graves’s disease.

J. clin. Endocr., 5, 345-52, 1945.

Clinical introduction of thiobarbital.

Subjects: ENDOCRINOLOGY › Thyroid
  • 3855.1

Imidazoles. IV. The synthesis and antithyroid activity of some 1-substituted-2-mercaptoimidazoles.

J. Amer. chem. Soc., 71, 4000-02, 1949.

Synthesis of methimazole (mercazole, thiamazole), an antithyroid drug more potent than methylthiouracil. With E. C. Kornfeld, K. C. McLaughlin, and R. C. Anderson.

  • 3855.2

Antithyroid activity of 2-carbethoxythio-1-methylglyoxaline.

Lancet, 2, 619-20, 1951.

Synthesis of Carbimazole. With C. Rimington and C. E. Searle. For clinical application see Lancet, 1951, 2, 621.

Subjects: ENDOCRINOLOGY › Thyroid
  • 2578.20
  • 3855.3

Studies on organ specificity. IV. Production of rabbit thyroid antibodies in the rabbit.

J. Immunol., 76, 408-16, 1956.

Autoimmune thyroiditis

  • 3856

Lieber erfolgreiche Einheilung der Katzenschilddrüse in die Bauchdecke und Auftreten von Tetanie nach deren Exstirpation.

Wien. klin. Wschr., 5, 81-85, 1892.

Experimental production of tetany by excision of the thyroid of a cat, previously successfully transplanted into the abdomen.

Subjects: ENDOCRINOLOGY › Parathyroids
  • 3857

Sugli effeti dell’ estirpazione delle ghiandole paratiroidee.

Riv. Patol. nerv. ment., 1, 95-99, 1896.

Demonstration that tetany follows removal of the parathyroids. A French translation of the paper is in Arch. ital. Biol., 1896, 25, 459-64.

Subjects: ENDOCRINOLOGY › Parathyroids
  • 3858

Ueber Ostitis deformans ohne osteoides Gewebe.

Arb. path.-anat. Inst. Tübingen, 4, 398-422, 1904.

Askanazy was the first to associate osteitis fibrosa cystica with parathyroid tumors.

Subjects: ENDOCRINOLOGY › Parathyroids
  • 3859

On the relation of tetany to the parathyroid glands and to calcium metabolism.

J. exp. Med., 11, 118-51, 1909.

Proof that the parathyroids control calcium metabolism. MacCallum and Voegtlin were able to demonstrate the removal of post-parathyroidectomy tetany by administration of calcium.

Subjects: ENDOCRINOLOGY › Parathyroids
  • 3860

Auto- and isotransplantation, in dogs, of the parathyroid glandules.

J. exp. Med., 11, 175-99, 1909.

  • 1136
  • 3861

The extraction of a parathyroid hormone which will prevent or control parathyroid tetany and which regulates the level of blood calcium.

J. biol. Chem., 63, 395-438, 1925.

Isolation of parathormone, the active principle of the parathyroids.

Collip’s “parathormone”. He showed that it raises the calcium level in para-thyroidectomized dogs.

Subjects: Ductless Glands: Internal Secretion › Thyroid, Parathyroids, ENDOCRINOLOGY › Parathyroids
  • 3862
  • 4837

A case of tetany treated with parathyrin.

Canad. med. Ass. J., 15, 59-60, 1925.

First use of parathyroid hormone in the treatment of tetany.

Subjects: ENDOCRINOLOGY › Parathyroids , NEUROLOGY › Tetany
  • 3863

Therapeutischer Versuch bei Ostitis fibrosa generalisata mittels Exstirpation eines Epithelkörperchentumors.

Wien. klin. Wschr., 38, 1343-44, 1925.

Mandl was the first successfully to treat generalized osteitis fibrosa by extirpation of a parathyroid tumor.

Subjects: ENDOCRINOLOGY › Parathyroids
  • 3864

On the constitutional and local effects of disease of the supra-renal capsules.

London: S. Highley, 1855.

Addison was the first to draw attention to the importance of the adrenals in clinical medicine. The above work first appeared in the Lond. med. Gaz., 1849, 43, 517-18, and was later expanded into book form. It described the conditions, which later became known as “Addison’s disease” and pernicious anemia, which was later renamed “Addisonian anemia” by Trousseau. Text reprinted in Med. Classics, 1937, 2, 244-77. Facsimile edition, London, Dawson, 1968.

Subjects: ENDOCRINOLOGY › Adrenals, HEMATOLOGY › Anemia & Chlorosis
  • 3865

Ein Fall von doppelseitigem, völlig latent verlaufenen Nebennieren-tumor und gleichzeitiger Nephritis mit Veränderungen am Circulationsapparat und Retinitis.

Virchows Arch. path. Anat., 103, 244-63, 1886.

Pheochromocytoma first described. Republished in book form.

Subjects: ENDOCRINOLOGY › Adrenals, NEPHROLOGY › Renal Disease, NEPHROLOGY › Renal Disease › Nephritis, ONCOLOGY & CANCER
  • 3866

A study of congenital sarcoma of the liver and suprarenal. With report of a case.

Amer. J. med. Sci., 121, 287-99, 1901.

Pepper’s type of adrenal medullary tumor.

  • 3867

On the relation of the suprarenal capsules to the sex organs.

Trans. path. Soc. Lond., 56, 189-208, 1905.

First recognition of the “adrenogenital syndrome”. This paper showed a relationship to exist between the adrenals and the sex organs.

Subjects: ENDOCRINOLOGY › Adrenals
  • 3868

On suprarenal sarcoma in children with metastases in the skull.

Quart. J. Med., 1, 33-38, 1907.

Hutchison’s tumors.

Subjects: ENDOCRINOLOGY › Adrenals, ONCOLOGY & CANCER, ONCOLOGY & CANCER › Sarcoma › Soft Tissue Sarcoma, PEDIATRICS
  • 3869

A tentative test for pheochromocytoma.

Amer. J. med. Sci., 210, 653-60, 1945.

The Roth–Kvale histamine test for the diagnosis of pheochromocytoma.

Subjects: ENDOCRINOLOGY › Adrenals, ONCOLOGY & CANCER, WOMEN, Publications by › Years 1900 - 1999
  • 3870

La virilisme pilaire et son association à l’insuffisance glycolytique (Diabète des femmes à barbe).

Bull. Acad. Méd., 3 sér., 86, 51-66, 1921.

“Achard–Thiers syndrome”. These writers established as a definite syndrome the combination of hirsutism with diabetes.

Subjects: ENDOCRINOLOGY › Adrenals, Metabolism & Metabolic Disorders › Diabetes
  • 3871

Crises solaires et hypertension paroxystique en rapport avec une tumeur surrénale.

Bull. Soc. méd. Hôp. Paris, 3 sér., 46, 982-90, 1922.

First full description of chromaffin cell tumors of the adrenal medulla. With J. Tinel and E. Doumer.

Subjects: ENDOCRINOLOGY › Adrenals, NEPHROLOGY › Renal Disease › Renal Hypertension, ONCOLOGY & CANCER
  • 3872

A case of virilism associated with a suprarenal tumour: recovery after its removal.

Quart. J. Med., 18, 143-52, 1925.

Records the first removal (by P. Sargent) of an adrenal cortical tumor. This was followed by disappearance of the heterosexual symptoms, thus establishing the relationship of sexual abnormality and adrenal tumors.

Subjects: ENDOCRINOLOGY › Adrenals
  • 3873

Suprarenal cortical extracts in suprarenal insufficiency (Addison’s disease).

J. Amer. med. Assoc., 92, 1569-71, 1929.

Rogoff and Stewart were the first to use adrenal cortical extract (“inter-renalin”) in the treatment of adrenal insufficiency. See also No. 1148.

Subjects: ENDOCRINOLOGY › Adrenals
  • 3874

The adrenal cortical hormone.

Medicine, 11, 371-433, 1932.

The cortical hormone prepared by Swingle and Pfiffner (“eschatin”) was found to be very effective in the treatment of Addison’s disease. Their first paper on the subject appeared in Science, 1930, 71, 321.

Subjects: ENDOCRINOLOGY › Adrenals
  • 3875

The adrenal cortex; a surgical and pathological study.

London: H. K. Lewis, 1933.

Includes the demonstration, by Vines, of virilism with the aid of a new stain; cortical cells of the adrenals removed at operation stained an abnormal (red) color – the so-called Ponceau fuchsin stain.

Subjects: ENDOCRINOLOGY › Adrenals
  • 3876

Genital abnormalities, hermaphroditism and related adrenal diseases.

Baltimore, MD: Williams & Wilkins, 1937.

Subjects: ENDOCRINOLOGY › Adrenals, SEXUALITY / Sexology › Intersex
  • 3877

Treatment of adrenal insufficiency by means of subcutaneous implants of pellets of desoxycorticosterone acetate (a synthetic adrenal cortical hormone).

Bull. Johns Hopk. Hosp., 64, 155-66, 1939.

With L. L. Engel and H. Eisenberg. For treatment of Addison’s disease by the same method, see the same journal, pp. 339-65.

Subjects: ENDOCRINOLOGY › Adrenals
  • 3877.1

Primary aldosteronism, a new clinical syndrome.

J. Lab. clin. Med., 45, 661-64, 1955.

Primary aldosteronism (“Conn’s syndrome”).

Subjects: ENDOCRINOLOGY › Adrenals
  • 3878

De cranii ustione in pertinacioribus capitis vitiis. In his: Ratio medendi in nosocomio practico, 6, 239-287. 8 vols.

Vienna: Herman Joseph Krüchten, 17581763.

Haen provided the first description of amenorrhea in connection with a pituitary tumor. He recorded the case history of a young woman suffering from amenorrhea as well as many neurological symptoms assumed to result from increased intracranial pressure, and a tumor in the area of the optic chiasma and the pituitary gland. Autopsy revealed a tumor in that location, and the tumor was correctly assumed to be the cause of the patient's illness and death. Digital facsimile from the Internet Archive at this link.

  • 3879

De curandis hominum morbis epitome. Liber V.

Mannheim: C. F. Schwann & C. G. Goetz, 1794.

Frank was the first to define diabetes insipidus (pp. 38-67).

Subjects: ENDOCRINOLOGY › Pituitary, Metabolism & Metabolic Disorders › Diabetes
  • 3880

Accroissement singulier en grosseur des os d’un homme âgé de 39 ans. In: Mélanges de chirurgie, 407-11.

Paris: E. Gay , 1801.

Saucerotte described before the Académie de Chirurgie in 1772 a case of what is now known to have been acromegaly. This is the first known clinical description of the disease, and is one of the five cases included in Pierre Marie’s classic account (No. 3884). Digital facsimile from the Internet Archive at this link.

Subjects: ENDOCRINOLOGY › Pituitary, SURGERY: General
  • 3881

Observations sur les maladies de l’appendice sus-sphenoïdal (glande pituitaire) du cerveau.

Arch. gén. Méd., 3, 350-67., 1823.

Includes description of pituitary obesity.

Subjects: ENDOCRINOLOGY › Pituitary
  • 3882

Hypertrophie der Hypophysis cerebri und dadurch bedingter Druck auf die Hirngrundfläche, insbesondere auf die Sehnerven, das Chiasma derselben und den linkseitigen Hirnschenkel.

Wschr. ges. Heilk., 6, 565-71, 1840.

The first case of pituitary obesity with infantilism (Fröhlich’s syndrome) was reported by Mohr. Coincidentally, this appears in the same volume of the Wochenschrift as does Basedow’s classic description of exophthalmic goitre.

Subjects: ENDOCRINOLOGY › Pituitary, ENDOCRINOLOGY › Thyroid
  • 3883

Du féminisme et de l’infantilisme chez les tuberculeux.

Paris: A. Parent, 1871.

In a letter prefaced to Faneau de La Cour’s thesis, Paul Joseph Lorain (1827-1875) described the idiopathic arrest of growth now known as “Lorain’s type”. It was subsequently ascribed to hypopituitarism. The word “infantilism” first appeared in this work. Digital facsimile from at this link.

Subjects: ENDOCRINOLOGY › Pituitary, INFECTIOUS DISEASE › Tuberculosis
  • 3884

Sur deux cas d’acromégalie. Hypertrophie singulière non congénitale des extrémités supérieures, inférieures et céphalique.

Rev. Méd., 6, 297-333, 1886.

In this, the first complete clinical description of the condition, Marie suggested the name “acromegaly”. The paper excited much interest and was translated into English and published by the New Sydenham Society, 1891.

Subjects: ENDOCRINOLOGY › Pituitary
  • 3885

Lieber einen Fall von Akromegalie.

Berl. klin. Wschr., 24, 371-74, 1887.

Minkowski called attention to the constancy of pituitary enlargement on acromegaly; he was the first definitely to note this relationship.

Subjects: ENDOCRINOLOGY › Pituitary
  • 3886

Notes on a case of acromegaly treated by operation.

Brit. Med. J., 2, 1421-23, 1893.

First attempt (unsuccessful) to treat acromegaly operatively. Decompression was performed to relieve cranial pressure.

Subjects: ENDOCRINOLOGY › Pituitary
  • 3887

Tumeur du corps pituitaire sans acromégalie et avec arrêt de développement des organes génitaux.

Rev. neurol. (Paris), 8, 531-33, 1900.

Babinski preceded Fröhlich in describing dystrophia adiposo-genitalis.

Subjects: ENDOCRINOLOGY › Pituitary
  • 3888

Beiträge zur normalen und pathologischen Histologie der menschlichen Hypophysis cerebri.

Berl. klin. Wschr., 37, 1205-10, 1900.

Benda showed that the pituitary tumor in acromegaly consists of chromophil cells.

  • 3889

Ein Fall von Tumor der Hypophysis cerebri ohne Akromegalie.

Wien. klin. Rdsch., 15, 883-86, 906-08, 1901.

Fröhlich’s classic description of dystrophia adiposogenitalis, pituitary tumor, with obesity and sexual infantilism (“Fröhlich’s syndrome”). Reprinted (in German) in Research Publications, Association for Nervous and Mental Disease, XX: The hypothalamus, Baltimore, 1940, pp. xvi-xxviii. Partial English translation in No. 2241.

  • 3890

Sexual infantilism with optic atrophy in cases of tumor affecting the hypophysis cerebri.

J. nerv. ment. Dis., 33, 704-16, 1906.

Subjects: ENDOCRINOLOGY › Pituitary, NEUROLOGY › Brain & Spinal Tumors
  • 3891

Zur Frage der Operationen an der Hypophyse.

Beitr. klin. Chir., 50, 767-817, 1906.

Schloffer’s Operation for acromegaly. He was the first successfully to operate upon a pituitary tumor in man (See No. 3892).

Subjects: ENDOCRINOLOGY › Pituitary, NEUROLOGY › Brain & Spinal Tumors
  • 3892

Erfolgreiche Operation eines hypophysen Tumors auf nasalem Wege.

Wien. klin. Wschr., 20, 621-24, 670-71, 1075-78, 1907.

Schloffer’s Operation by the nasal route.

Subjects: ENDOCRINOLOGY › Pituitary, NEUROLOGY › Brain & Spinal Tumors
  • 3893

Insuffisance thyro-ovarienne et hyperactivité hypophysaire (troubles acromégaliques).

Bull. Soc. méd. Hôp. Paris, 3 sér., 25, 973-79, 1908.

Rénon–Delille syndrome – dyspituitarism manifested by lowered blood-pressure, tachycardia, oliguria, insomnia, hyperhidrosis, and intolerance to heat.

Subjects: ENDOCRINOLOGY › Pituitary
  • 1160
  • 3894

Experimental hypophysectomy.

Johns Hopk. Hosp. Bull, 21,127-69, 1910.

First experimental evidence of the relationship between the pituitary and the reproductive system; demonstration that hypophysectomy causes genital atrophy. 

Subjects: Ductless Glands: Internal Secretion › Pituitary, ENDOCRINOLOGY › Pituitary
  • 3895

Eine neue Methode der endonasalen operation von Hypophysentumoren.

Wien med. Wschr., 59, 646-637, 1909.

Hirsch first demonstrated the transnasal transseptal exposure of the sphenoid sinus and pituitary gland in a cadaveric specimen in front of the medical society of Vienna.

Subjects: ENDOCRINOLOGY › Pituitary, NEUROLOGY › Brain & Spinal Tumors
  • 3896
  • 4883.1

The pituitary body and its disorders.

Philadelphia: J. B. Lippincott, 1912.

The first clinical monograph on the hypophysis. Cushing, outstanding neurological surgeon of the early 20th century, added much to our knowledge of the pituitary body and its disorders. The above work includes a description of his own method of operating on the pituitary. He assumed that in diabetes insipidus the pituitary was involved. Cushing also described obesity caused by basophil pituitary tumor. See No. 1161.


Subjects: ENDOCRINOLOGY › Pituitary, Metabolism & Metabolic Disorders › Diabetes, NEUROSURGERY, Obesity Research
  • 3897

Ueber Beziehungen der Hypophyse zum Diabetes insipidus.

Berl. klin., Wschr., 49, 393-97, 1912.

Frank was the first definitely to connect the posterior lobe of the pituitary with diabetes insipidus.

Subjects: ENDOCRINOLOGY › Pituitary, Metabolism & Metabolic Disorders › Diabetes
  • 3898

Acromegaly: a personal experience.

London: Baillière, Tindall & Cox, 1912.

Mark, a medical practitioner, suffered from acromegaly from the age of 24. The condition was obvious to his friends, but Mark was 50 before he realized the cause of the symptoms of which he had kept a record for many years. He left an interesting account of his personal experience and also drew attention to several sculptural and pictorial representations of acromegalics.

Subjects: BIOGRAPHY (Reference Works) › Autobiography, ENDOCRINOLOGY › Pituitary
  • 3899

Infantilism hypophysaire.

Nouv. Iconogr. Salpêt, 26, 69-80, 1913.

Classic account of pituitary infantilism.

Subjects: ENDOCRINOLOGY › Pituitary