1932 –1934 FISCHL, Viktor; SCHLOSSBERGER, Hans (1887 – 1960)

Handbuch der Chemotherapie. 2 vols.

GMN 1921 · https://historyofmedicine.com/id/2705

1946 GOODMAN, Louis Sanford (1906 – 2000); GILMAN, Alfred Zack (1908 – 1984); WINTROBE, Maxwell Myer (1901 – 1986); DAMESHEK, William (1900 – 1969)

Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders.

Widely considered the first uses of chemotherapy for the treatment of malignant diseases.

GMN 10133 · https://historyofmedicine.com/id/12322

1953 EVERETT, James Lionel

Aryl-2-halogenoalkylamines. Part XII. Some carboxylic derivatives of NN-Di 2-chloroethylaniline.

Chlorambucil (a nitrogen mustard) used in the chemotherapy of cancer. With J. R. Roberts and W. J. C. Ross.

GMN 2660.4 · https://historyofmedicine.com/id/3380

1954 BERGEL, Franz (1900 – 1987); STOCK, J. A.

Cytoactive amino-acid and peptide derivatives. I. Substituted phenylalanines.

Melphalan (a nitrogen mustard) later used in the chemotherapy of cancer.

GMN 2660.7 · https://historyofmedicine.com/id/3387

1970 DE VITA, Vincent Theodore Jr. (1935 – ); ET AL

Combination chemotherapy in the treatment of advanced Hodgkin’s disease.

Combination chemotherapy with nitrogen mustard (mustine hydrochloride), vincristine sulphate, procarbazine hydrochloride and prednisone, introduced in 1964 for the treatment of advanced Hodgkin’s disease. With A. A. S…

GMN 2660.24 · https://historyofmedicine.com/id/3434

1991 FREIREICH, Emil J. (1927 – ); LEMAK, Noreen Ann (1921 – 2013)

Milestones in leukemia research and therapy.

Freireich was part of the team that first introduced combined-drug cancer chemotherapy in 1965.

GMN 8650 · https://historyofmedicine.com/id/10827