1666 MALPIGHI, Marcello (1628 – 1694)
De viscerum structura exercitatio anatomica.
Includes (pp. 71-100) his essay, De renibus, in which he described the uriniferous tubules and the “Malpighian bodies”. The great detail and clarity of Malpighi’s description was unsurpassed until Bowman (No. 1231). T…
GMN 1230 · https://historyofmedicine.com/id/153
1832 HODGKIN, Thomas (1798 – 1866)
On some morbid appearances of the absorbent glands and spleen.
First full description of lymphadenoma, which Wilks in 1865 referred to as “Hodgkin’s disease”. This is more typically designated as Hodgkin's lymphoma. In 1666 Malpighi had vaguely outlined the condition. Hodgkin was…
GMN 3762 · https://historyofmedicine.com/id/4624
1856 WILKS, Sir Samuel (1824 – 1911)
Cases of a peculiar enlargement of the lymphatic glands frequently associated with disease of the spleen.
Wilks really put Hodgkin’s disease “on the map”; the second paper for the first time attached Hodgkin’s name to the disease
GMN 3764 · https://historyofmedicine.com/id/4641
1872 LANGHANS, Theodor (1839 – 1915)
Das maligne Lymphosarkom (Pseudoleukämie).
Langhans noted the presence of giant cells in the lesions of Hodgkin’s disease.
GMN 3767 · https://historyofmedicine.com/id/4651
1892 DRESCHFELD, Julius (1845 – 1907)
Clinical lecture on acute Hodgkin’s disease
Dreschfeld preceded Kundrat in differentiating Hodgkin’s disease and lymphosarcoma.
GMN 3772 · https://historyofmedicine.com/id/4659
1902 MENDENHALL, Dorothy Mabel Reed (1874 – 1964)
On the pathological changes in Hodgkin’s disease, with especial reference to its relation to tuberculosis.
Dorothy Reed’s classic work on Hodgkin’s disease included a study of the histological picture. She described the proliferation of the endothelial and reticular cells, and the formation of lymphadenoma cells – “Dorothy…
GMN 3780 · https://historyofmedicine.com/id/4677
1939 GILBERT, René
Radiotherapy in Hodgkin’s disease (malignant granulomatosis). Anatomic and clinical foundations; governing principles; results.
Gilbert was among the first to achieve durable responses to radiotherapy in Hodgkin’s disease.
GMN 3787.2 · https://historyofmedicine.com/id/4696
1946 GILMAN, Alfred Zack (1908 – 1984); PHILLIPS, Frederick Stanley (1916 – )
The biological actions and therapeutic applications of the ß-chloroethyl amines and sulfides.
Introduction of nitrogen mustard in treatment of Hodgkin’s disease
GMN 3788 · https://historyofmedicine.com/id/4698
1946 GOODMAN, Louis Sanford (1906 – 2000); GILMAN, Alfred Zack (1908 – 1984); WINTROBE, Maxwell Myer (1901 – 1986); DAMESHEK, William (1900 – 1969)
Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders.
Widely considered the first uses of chemotherapy for the treatment of malignant diseases.
GMN 10133 · https://historyofmedicine.com/id/12322
1955 GALTON, David Abraham Goiten (1922 – 2007)
Clinical trials of p-(DI-2-chloroethylamino)-phenylbutyric acid (CB 1348) in malignant lymphoma.
Clinical use of chlorambucil for chronic lymphatic leukemia. With L. G. Israels, J. D. N. Nabarro, and M. Till.
GMN 3108.6 · https://historyofmedicine.com/id/3831
1956 HATA, Toju (1908 – 2004); ET AL
Mitomycin, a new antibiotic from streptomyces.
Isolation of mitomycin C, effective in Hodgkin’s disease and lymphoma. With six co-authors.
GMN 1947.3 · https://historyofmedicine.com/id/2817
1958 –1959 BURKITT, Denis Parsons (1911 – 1993)
A sarcoma involving the jaws in African children.
Burkitt’s lymphoma (African lymphoma), first described in detail by Sir Albert Cook, a medical missionary, but not published by him.
GMN 2660.12 · https://historyofmedicine.com/id/3397
1964 EPSTEIN, Michael Anthony (1921 – ); BARR, Yvonne (1932 – 2016)
Cultivation in vitro of human lymphoblasts from Burkitt’s malignant lymphoma.
Order of authorship in the original publication: Epstein, Barr. Discovery of the Epstein-Barr virus, a human herpes virus causing infectious mononucleosis, and implicated in Burkitt’s lymphoma and other forms of cance…
GMN 2660.17 · https://historyofmedicine.com/id/3410
1964 EPSTEIN, Michael Anthony (1921 – ); BARR, Yvonne (1932 – 2016); ACHONG, Bert Geoffrey (1928 – 1996)
Virus particles in cultured lymphoblasts from Burkitt’s lymphoma.
Order of authorship in the original publication: Epstein, Achong, Barr. Presence of herpes-like virus particles in Burkitt’s tumor cells reported. The Epstein-Barr virus was the first human cancer-causing virus to be …
GMN 2660.18 · https://historyofmedicine.com/id/3414
1964 PULVERTAFT, Robert James Valentine (1897 – 1990)
Cytology of Burkitt’s tumour (African lymphoma).
GMN 2660.19 · https://historyofmedicine.com/id/3415
1970 DE VITA, Vincent Theodore Jr. (1935 – ); ET AL
Combination chemotherapy in the treatment of advanced Hodgkin’s disease.
Combination chemotherapy with nitrogen mustard (mustine hydrochloride), vincristine sulphate, procarbazine hydrochloride and prednisone, introduced in 1964 for the treatment of advanced Hodgkin’s disease. With A. A. S…
GMN 2660.24 · https://historyofmedicine.com/id/3434
1973 SHOPE, Thomas
Malignant lymphoma in cottontop marmosets after inoculation with Epstein–Barr virus.
Epstein-Barr virus as a cause of Burkitt’s lymphoma. With D. DeChairo and G. Miller.
GMN 2660.25 · https://historyofmedicine.com/id/3436
1980 GALLO, Robert Charles (1937 – ); POIESZ, Bernard J.; RUSCETTI, Francis W.; ET AL
Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.
Order of authorship in the original publication: Poiesz, Ruscetti,... Gallo. Gallo and associates announced the discovery of a human retrovirus with type C morphology causing a cutaneous T-cell lymphoma. Gallo named t…
GMN 11057 · https://historyofmedicine.com/id/13253
1998 CERRONI, Lorenzo (1959 – ); KERL, Helmut; GATTER, Kevin
An illustrated guide to skin lymphoma.
GMN 7322 · https://historyofmedicine.com/id/9492
2018 BARDINET, Thierry
Médecins et magiciens á la cour du pharaon. Une étude du papyrus médical Louvre E 32847.
Transcription, French translation, and study of this papyrus dating from the reign of Amenophis II (1424-1398 BCE). The papyrus, written for teaching purposes, concerns diagnosis of pathology in the elderly, tumors (i…
GMN 9711 · https://historyofmedicine.com/id/11898
