1757 LE DRAN, Henri François (1685 – 1770)
Mémoire avec un précis de plusieurs observations sur le cancer.
Le Dran discarded the humoral conception of cancer for the first time. He regarded cancer as a local disease in its early stage and knew that it spread via the lymphatics to regional nodes, and from there into the gen…
GMN 2607 · https://historyofmedicine.com/id/3056
1817 LANGSTAFF, George (1780 – 1846)
Cases of Fungus haematodes, with observations.
Prostatic carcinoma first reported (p. 279).
GMN 4258 · https://historyofmedicine.com/id/5207
1851 ADAMS, John (1806 – 1877)
The anatomy and diseases of the prostate gland.
Adams was the first to distinguish between hypertrophy and carcinoma of the prostate. Digital facsimile from the Internet Archive at this link.
GMN 4260 · https://historyofmedicine.com/id/5215
1863 –1867 VIRCHOW, Rudolf Ludwig Karl (1821 – 1902)
Die krankhaften Geschwülste. Vol. 1-3, Heft 1.
Although tumours were perhaps his greatest interest, Virchow never completed this work which was intended to have 30 lectures. Instead he stopped with the 25th lecture, on carcinoma, probably because of the vigorous a…
GMN 2617 · https://historyofmedicine.com/id/3127
1867 WALDEYER-HARTZ, Heinrich Wilhelm Gottfried von (1836 – 1921)
Die Entwicklung der Carcinome.
Waldeyer confirmed the work of Thiersch (No. 2618) on the epithelial origin of cancer, disproving Virchow’s theory (No. 2617). So great was the authority of the latter that it was not until the appearance of the secon…
GMN 2620 · https://historyofmedicine.com/id/3141
1877 CHIARI, Hans (1851 – 1916)
Uber drei Fälle von primärem Carcinom im Fundus und Corpus des Uterus.
Choriocarcinoma first reported.
GMN 6066.1 · https://historyofmedicine.com/id/7442
1879 PÉAN, Jules-Émile (1830 – 1898)
De l’ablation des tumeurs de l’estomac par la gastrectomie.
First gastrectomy for carcinoma; unsuccessful.
GMN 3472 · https://historyofmedicine.com/id/5644
1880 KOCHER, Emil Theodor (1841 – 1917)
Ueber Radicalheilung des Krebses.
Kocher’s operation of radical extirpation of the tongue for carcinoma.
GMN 3473 · https://historyofmedicine.com/id/5647
1886 MIKULICZ-RADECKI, Jan (Johann Freiherr von) (1850 – 1905)
Ein Fall von Resection des carcinomatösen Oesophagus mit plastischem Ersatz des excidierten Stückes.
Von Mikulicz was the first to make a plastic reconstruction of the oesophagus after the resection of its cervical portion for carcinoma.
GMN 3487 · https://historyofmedicine.com/id/3881
1887 KRASKE, Paul (1851 – 1930)
Die sacrale Methode der Exstirpation von Mastdarmkrebsen und die Resectio recti.
Kraske introduced the sacral method of resection of the rectum for carcinoma.
GMN 3490 · https://historyofmedicine.com/id/3889
1893 FRANK, Rudolf (1862 – 1913)
Eine neue Methode der Gastrostomie bei Carcinoma oesophagi.
See No. 3512.
GMN 3508 · https://historyofmedicine.com/id/3966
1894 –1895 HALSTED, William Stewart (1852 – 1922)
The results of operations for the cure of cancer of the breast performed at the Johns Hopkins Hospital from June, 1889, to January, 1894.
Halsted’s operation invariably excised the pectoralis major muscle in radical mastectomy. His operation, modified by the retention of the pectoral muscles, remains the cornerstone of surgical treatment of carcinoma of…
GMN 5640 · https://historyofmedicine.com/id/7262
1895 REHN, Ludwig (1849 – 1930)
Blasengeschwülste bei Fuchsin-Arbeitem.
Rehn noted the frequent appearance of papilloma and carcinoma of the bladder among men employed in the aniline dye industry.
GMN 2128.1 · https://historyofmedicine.com/id/2659
1895 MARCHAND, Felix Jacob (1846 – 1928)
Über die sogenannten “decidualen” Geschwülste im Anschluss an normale Geburt, Abort, Blasenmole und Extrauterinschwangerschaft.
Marchand’s theory of the histogenesis of choriocarcinoma (chorionepithelioma). He considered that such tumors derived from trophoblast and not from decidua.
GMN 6097.1 · https://historyofmedicine.com/id/7522
1895 WILLIAMS, John Whitridge (1866 – 1931)
Deciduoma malignum.
First case of choriocarcinoma reported in North America.
GMN 6100 · https://historyofmedicine.com/id/7529
1896 BEATSON, Colonel Sir George Thomas (1848 – 1933)
On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment, with illustrative cases.
Öophorectomy in the treatment of breast cancer.
GMN 5778.1 · https://historyofmedicine.com/id/6824
1903 PERTHES, Georg Clemens (1869 – 1927)
Ueber den Einfluss der Röntgenstrahlen auf epitheliale Gewebe, insbesondere auf das Carcinom.
Perthes was among the first to study the inhibitory effect of x rays on carcinoma; he was a pioneer in radiotherapy.
GMN 2627.1 · https://historyofmedicine.com/id/3198
1903 SCHMIDT, Martin Benno (1863 – 1949)
Die Verbreitungswege der Karzinome und die Beziehung generalisierter Sarkome zu den leukämischen Neubildungen.
Schmidt supported the theory of the hematogenous origin of carcinoma metastases.
GMN 2629 · https://historyofmedicine.com/id/3209
1903 ALBARRAN Y DOMINGUEZ, Joaquin Maria (1860 – 1912); IMBERT, Léon (1868 – 1955)
Les tumeurs du rein.
Seminal work on renal tumors with unsurpassed descriptions of the clinical semiology of these diseases. In 1903 Albarran was the first "... to diagnose transitional cell carcinoma of the renal pelvis by detecting mali…
GMN 7217 · https://historyofmedicine.com/id/9384
1905 YOUNG, Hugh Hampton (1870 – 1945)
The early diagnosis and radical cure of carcinoma of the prostate. Being a study of 40 cases and presentation of a radical operation which was carried out in four cases.
First radical prostatectomy for carcinoma.
GMN 4266.1 · https://historyofmedicine.com/id/5245
1906 –1907 GRAY, Alfred Leftwich (1873 – 1932)
The treatment of malignant diseases of the bladder through suprapubic incision, with report of a case.
Radiotherapy for carcinoma of bladder.
GMN 4194.1 · https://historyofmedicine.com/id/6134
1908 MILES, William Ernest (1869 – 1947)
A method of performing abdomino-perineal excision for carcinoma of the rectum and of the terminal portion of the pelvic colon.
Miles devised the operation of abdomino-perineal resection.
GMN 3528.1 · https://historyofmedicine.com/id/4023
1908 SCHAUTA, Friedrich (1849 – 1919)
Die erweiterte vaginale Totalexstirpation des Uterus bei Kollumkarzinom.
Radical vaginal hysterectomy for carcinoma of the cervix.
GMN 6120 · https://historyofmedicine.com/id/7577
1909 LAZARUS-BARLOW, Walter Sydney (1865 – 1950)
The Croonian Lectures on radioactivity and carcinoma.
GMN 2635 · https://historyofmedicine.com/id/3227
1910 MAYO, William James (1861 – 1939)
Removal of the rectum for cancer: statistical report of 120 cases.
Mayo’s radical operation for carcinoma of the rectum.
GMN 3534 · https://historyofmedicine.com/id/4031
1911 TROTTER, Wilfred Batten Lewis (1872 – 1939)
On certain clinically obscure malignant tumours of the naso-pharyngeal wall.
“Trotter’s syndrome”; deafness, palatal paralysis, and facial neuralgia, usually due to a nasopharyngeal carcinoma.
GMN 3319.1 · https://historyofmedicine.com/id/4542
1913 FIBIGER, Johannes (1867 – 1928)
Untersuchungen über eine Nematode (Spiroptera sp. n.) und deren Fähigkeit papillomatöse und carcinomatose Geschwulstbildungen im Magen der Ratte hervorzurufen.
Fibiger demonstrated that the roundworm, which he called Spiroptera carcinoma (but is correctly named Gongylonema neoplasticum), could cause stomach cancer (squamous cell carcinoma) in rats and mice. His experimental …
GMN 2640 · https://historyofmedicine.com/id/3257
1913 TOREK, Franz John A. (1861 – 1938)
The first successful case of resection of the thoracic portion of the oesophagus for carcinoma.
See also Arch. Surg. (Chicago), 1925, 10, 353-60, which reported that the patient was still living.
GMN 3540 · https://historyofmedicine.com/id/4045
1913 WARTHIN, Aldred Scott (1866 – 1931)
Heredity with reference to carcinoma: As shown by the study of the cases examined in the pathological laboratory of the University of Michigan, 1895-1913.
"In 1895, a young seamstress of his [Warthin's] acquaintance told him about her family's long history of cancer deaths.[6] Intrigued, he researched her family's history, searching death records and administering quest…
GMN 9443 · https://historyofmedicine.com/id/11626
1916 TYZZER, Ernest Edward (1875 – 1965); LITTLE, Clarence Cook (1888 – 1971)
Further experimental studies on the inheritance of susceptibility to a transplantable tumour, carcinoma (J. W. A.) of the Japanese waltzing mouse.
Marks the beginning of the study of histocompatibility antigens.
GMN 2570 · https://historyofmedicine.com/id/3701
1921 COUTARD, Henri (1876 – 1950)
Un cas d’épithélioma spino-cellulaire de la région latérale du pharynx, avec adénopathie angulo-maxillaire, guéri depuis six mois par la röntgenthérapie.
Carcinoma of pharynx cured by the Coutard method of Röntgen therapy.
GMN 3196 · https://historyofmedicine.com/id/4263
1926 BARNARD, William George (1892 – 1956)
The nature of the “oat-celled sarcoma” of the mediastinum.
An important study of the histology of “oat-celled sarcoma” which Barnard showed to be primary carcinoma of the lung.
GMN 3201 · https://historyofmedicine.com/id/4298
1927 WILDER, Russell Morse (1885 – 1959); ET AL
Carcinoma of the islands of the pancreas; hyperinsulinism and hypoglycemia.
R. M. Wilder, F. N. Allan, M. H. Power, and H. E. Robertson reported the occurrence of carcinoma with hyperinsulinism. They also reported the first operation for hyperinsulinism performed on December 2, 1926 by Willia…
GMN 3972 · https://historyofmedicine.com/id/5280
1932 KEYNES, Sir Geoffrey Langdon (1887 – 1982)
The radium treatment of carcinoma of the breast.
Keynes’s successes with radium in breast cancer established this method of conservative treatment. His first paper on the subject, with the same title, was published in St. Barth. Hosp. Rep., 1927, 60, 91-95.
GMN 5786 · https://historyofmedicine.com/id/6846
1933 GRAHAM, Evarts Ambrose (1883 – 1957); SINGER, Jacob Jesse (1882 – 1954)
Successful removal of entire lung for carcinoma of the bronchus.
First reported case: April 5, 1933.
GMN 3205 · https://historyofmedicine.com/id/4326
1933 ADAIR, Frank Earl (1887 – 1981)
Plasma cell mastitis–a lesion simulating mammary carcinoma.
First description of plasma-cell mastitis.
GMN 5788 · https://historyofmedicine.com/id/6854
1933 SCHILLER, Walter (1887 – 1960)
Early diagnosis of carcinoma of the cervix.
Schiller’s test for carcinoma of the cervix.
GMN 6132 · https://historyofmedicine.com/id/7637
1935 WHIPPLE, Allen Oldfather (1881 – 1963); ET AL
Treatment of carcinoma of the ampulla of Vater.
Pancreaticoduodenectomy for cancer of pancreas. With W. B. Parsons and C. R. Mullins.
GMN 3659.1 · https://historyofmedicine.com/id/4789
1937 BONSER, Georgiana May (1898 – 1979)
The carcinogenic action of oestrone: induction of mammary carcinoma in female mice of a strain refractory to the spontaneous development of mammary tumours.
With L. H. Stickland and K. I. Connal.
GMN 2659 · https://historyofmedicine.com/id/3339
1937 BRUNSCHWIG, Alexander (1901 – 1969)
Resection of head of pancreas and duodenum for carcinoma – pancreatoduodenectomy.
See also the same journal, 1943, 77, 581-84.
GMN 3660 · https://historyofmedicine.com/id/4804
1939 MÜLLER, Franz Hermann
Tabakmissbrauch und Lungencarcinom.
In the first case-control epidemiological study of the effects of tobacco Müller recorded a statistically significant correlation between cigarette smoking and lung cancer. See Alfredo Morabia, "Quality, originality, …
GMN 3213 · https://historyofmedicine.com/id/4354
1941 HUGGINS, Charles Brenton (1901 – 1997); HODGES, Clarence Vernard (1914 – 2001)
Studies on prostatic cancer. I. The effect of castration, of estrogen, and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate.
In 1966 Huggins was awarded the Nobel Prize for Physiology or Medicine for discovering in 1941 "for his discoveries concerning hormonal treatment of prostatic cancer."
GMN 4276 · https://historyofmedicine.com/id/5291
1941 PAPANICOLAOU, George Nicholas (1883 – 1962); TRAUT, Herbert Frederick (1894 – 1963)
The diagnostic value of vaginal smears in carcinoma of the uterus.
The first cytopathology test, smear diagnosis of carcinoma of the cervix: the "Pap" test. Papanicolaou first reported in 1928 that he could recognize cancer cells (Proc. Third Race Betterment Conf., p. 528) but the im…
GMN 6135 · https://historyofmedicine.com/id/7663
1943 PAPANICOLAOU, George Nicholas (1883 – 1962); TRAUT, Herbert Frederick (1894 – 1963)
Diagnosis of uterine cancer by the vaginal smear.
"In 1943, after a three-year period of concentrated collaborative experience with the vaginal smear for the diagnosis of gynecologic cancer, Papanicolaou and Traut published their widely heralded monograph, Diagnosis …
GMN 13597 · https://historyofmedicine.com/id/15876
1945 HUGGINS, Charles Brenton (1901 – 1997); SCOTT, William Wallace (1913 – 2000)
Bilateral adrenalectomy in prostatic cancer; clinical features and urinary excretion of 17-ketosteroids and estrogen.
Adrenalectomy for carcinoma of the prostate.
GMN 4276.1 · https://historyofmedicine.com/id/5295
1950 GRAHAM, Evarts Ambrose (1883 – 1957); WYNDER, Ernst Ludwig (1922 – 1999)
Tobacco smoking as a possible etiologic factor in bronchogenic carcinoma: A study of 684 proved cases.
A case-control study proving an association between heavy prolonged cigarette smoking and bronchogenic carcinoma. See also the following paper on pp. 336-38. Reprinted in J. Amer. med. Assoc. 1985, 253, 2986-97.
GMN 3215.1 · https://historyofmedicine.com/id/4362
1950 DOLL, Sir William Richard Shaboe (1912 – 2005); HILL, Sir Austin Bradford (1897 – 1999)
Smoking and carcinoma of the lung. Preliminary report.
A study of 1,465 cases of lung cancer and 1,465 matched controls, which confirmed and extended the studies of Wynder and Graham, and others. See also later papers by the same authors in Brit. med. J., 1952, 2,1271-86;…
GMN 3215.2 · https://historyofmedicine.com/id/4373
1952 GEY, George Otto (1899 – 1970); COFFMAN, Ward D.; KUBICEK, Mary T.; LACKS, Henrietta (1920 – 1951)
Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium.
A cell biologist at Johns Hopkins Hospital, Gey propagated the HeLa cell line from Henrietta Lacks' cervical tumor. This cell line, which maintained a continuous growth phase, was the first immortal human cell line to…
GMN 14100 · https://historyofmedicine.com/id/16411
1978 MOHS, Frederick Edward (1910 – 2002)
Chemosurgery: Microscopically controlled surgery for skin cancer.
Mohs surgery for common types of skin cancer.
GMN 11440 · https://historyofmedicine.com/id/13639
1983 HAUSEN, Harald zur (1936 – ); DÜRST, Matthias; GISSMANN, Lutz (1949 – ); IKENBERG, Hans (1954 – )
A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions,
Zur Hausen and colleageus identified HPV 16 DNA in cervical cancer tumors by Southern blot hybridization. Digital facsimile from PubMedCentral at this link.
GMN 12663 · https://historyofmedicine.com/id/14907
