1921 D'HÉRELLE, Félix Hubert (1873 – 1949)

Le bactériophage: Son rôle dans l'immunité.

D'Hérrelle cited several actual reports of successful treatment of bacterial infections by the injection of bacteriophages in animals and humans. These may be considered early attempts at direct gene transfer in vivo …

GMN 10196 · https://historyofmedicine.com/id/12385

1980 BERG, Paul (1926 – ); MULLIGAN, Richard C. (1954 – )

Expression of a bacterial gene in mammalian cells.

(Order of authorship in the original publication: Mulligan, Berg.) In an understated paper the authors suggested the potential of treating recessive diseases like Lesch-Nyhan syndrome by gene therapy. (Thanks to Juan …

GMN 12304 · https://historyofmedicine.com/id/14526

1980 CLINE, Martin J. (1934 – ); STANG, Howard J.; MERCOLA, Karen E.; SALSER, Winston; ET AL

Gene transfer in intact animals.

Cline and colleagues were the first to successfully transfer a functioning gene into a living mouse, creating the first transgenic organism.

GMN 13918 · https://historyofmedicine.com/id/16212

1994 LEDERBERG, Joshua (1925 – 2008); WOLFF, Jon Asher (1956 – 2020)

A history of gene transfer and therapy by Jon A. Wolff and Joshua Lederberg in: Wolff, Jon A. (ed.) Gene therapeutics: Methods and applications of direct gene transfer, pp.3-25.

Valuable for its detailed, but highly compressed discussion of the earliest history of these subjects, co-authored by Lederberg, who played a significant role during that period.

GMN 10195 · https://historyofmedicine.com/id/12384

2000 FISCHER, Alain (1949 – ); CAVAZZANA, Marina (1959 – ); HACEIN-BEY-ABINA, Salima

Gene therapy of severe combined immunodeficiency (SCID)-XI disease.

In 1999, With Marina Cavazzana-Calvo and Salima Hacein-Bey, Fischer achieved the first clinical successes in the world of gene therapies for about ten bubble children,[8] two of whom unfortunately developed leukaemias…

GMN 13943 · https://historyofmedicine.com/id/16241