1982 ALLISON, James Patrick (1948 – ); MCINTYRE, B. W.; BLOCH, D.

Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody.

In 1982 Allison discovered the T-cell receptor. Order of authorship in the original publication: Allison, Bloch, McIntyre.

GMN 14266 · https://historyofmedicine.com/id/16587

1992 HONJO, Tasuko (1942 – ); ISHIDA, Yasumasa; AGATA, Yasutoshi; SHIBAHARA, Keiichi

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

Honjo discovered the programmed cell death protein 1 (PD-1). This discovery significantly contributed to the establishment of cancer immunotherapy principle by PD-1 blockade. Order of authorship in the original public…

GMN 14268 · https://historyofmedicine.com/id/16589

1996 LEMAITRE, Bruno (1965 – ); NICOLAS, Emmanuelle; HOFFMANN, Jules A. (1941 – ); ET AL

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults.

Order of authorship in the original publication: Lemaitre, Nicolas,... Hoffmann. This paper represented the foundation of molecular immunology. Hoffmann and colleagues found that flies with mutated Toll genes were una…

GMN 12111 · https://historyofmedicine.com/id/14320

1996 ALLISON, James Patrick (1948 – ); LEACH, D. R.; KRUMMEL, Matthew F. (1968 – )

Enhancement of antitumor immunity by CTLA-4 blockade.

In the early 1990s James Allison showed that CTLA-4 acts as an inhibitory molecule to restrict T-cell responses. In 1996, Allison was the first to show that antibody blockade of a T-cell inhibitory molecule (known as …

GMN 14267 · https://historyofmedicine.com/id/16588

1998 POLTORAK, Alexander; SMIRNOVA, Irina; BEUTLER, Bruce Alan (1957 – ); ET AL

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in the Tlr4 gene.

Order of authorship in the original paper: Poltorak, Smirnova...Beutler. The authors, led by Beutler, showed that mice that harbor a mutation of the gene which codes for the production of the Toll-like receptor TLR4 q…

GMN 12112 · https://historyofmedicine.com/id/14321

2005 KARIKÓ, Katalin (1955 – ); WEISSMAN, Drew; BUCKSTEIN, Michael; NI, Houping

Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA.

Karikó and Weissman discovered the nucleoside modifications that suppress the immungenicity of RNA, leading to their patents for the application of non-immunogenic, nucleoside-modified RNA (modRNA). This technology wa…

GMN 13622 · https://historyofmedicine.com/id/15902

2020 JIANG, Chenyang; LIAN, Xiadong; GAO, Ce; ET AL

Distinct viral reservoirs in individuals with spontaneous control of HIV-1.

The authors describe a mechanism for the observed natural viral "immunity" of individuals with spontaneous control of HIV-1. A very few exceptional people have the molecular ability to steer the incoming/infecting cel…

GMN 13479 · https://historyofmedicine.com/id/15753