1941 HAGGIS, Alec William (1889 – 1946)
Fundamental errors in the early history of cinchona.
GMN 2060 · https://historyofmedicine.com/id/2326
1941 ABRAHAM, Sir Edward Penley (1913 – 1999); CHAIN, Sir Ernst Boris (1906 – 1979); FLOREY, Howard Walter (1898 – 1968); HEATLEY, Norman George (1911 – 2004); GARDNER, Andrew Duncan (1884 – 1977); JENNINGS, Margaret Augusta (1904 – 1994); FLETCHER, Charles M.
Further observations on penicillin.
First report of the chemotherapeutic action of penicillin on humans (10 cases).
GMN 1934.1 · https://historyofmedicine.com/id/2785
1941 FINLAND, Maxwell (1902 – 1987); ET AL
Sulfadiazine. Therapeutic evaluation and toxic effects on four hundred and forty-six patients.
Introduction of sulphadiazine. With E. Strauss and O. L. Peterson.
GMN 1956 · https://historyofmedicine.com/id/2839
1941 POTH, Edgar Jacob (1899 – ); KNOTTS, Frank Louis (1912 – 1989)
Succinyl sulfathiazole, a new bacteriostatic agent locally active in the gastrointestinal tract.
Introduction of sulfasuxidine.
GMN 1957 · https://historyofmedicine.com/id/2842
1941 WYMAN, Leland Clifton (1897 – 1988); HARRIS, Stuart K.
Navajo Indian medical ethnobotany. University of New Mexico Bulletin, Anthropological Series, Vol. 3, No. 5.
Digital facsimile from herbaltherapeutics.net at this link.
GMN 9281 · https://historyofmedicine.com/id/11463
1942 MACARTNEY, Donald William; ET AL
Sulphamethazine: Clinical trial of a new sulphonamide.
Sulfadimidine (also spelled Sulphadimidine) with G. S. Smith, R. W. Luxton, W. A. Ramsay, and J. Goldman. [Also designated as Vol. 239 by publishers of The Lancet.]
GMN 1958 · https://historyofmedicine.com/id/2844
1942 RICH, Arnold Rice (1893 – 1968)
The rôle of hypersensitivity in periarteritis nodosa; as indicated by seven cases developing during serum sickness and sulfonamide therapy.
Rich considered hypersensitivity to be an important factor in the aetiology of periarteritis nodosa.
GMN 2924 · https://historyofmedicine.com/id/4922
1942 ABRAHAM, Sir Edward Penley (1913 – 1999); CHAIN, Sir Ernst Boris (1906 – 1979)
Purification of penicillin.
Abraham and Chain first announced the purification of penicillin, a critical step before production of the drug could begin, in a two paragraph paper published on a single page of Nature on March 21, 1942. The method,…
GMN 14282 · https://historyofmedicine.com/id/16605
1943 STOLL, Arthur (1887 – 1971); HOFMANN, Albert (1906 – 2008)
Partialsynthese von Alkaloiden vom Typus des Ergobasins.
Synthesis of lysergic acid diethylamide (LSD).
GMN 1928.1 · https://historyofmedicine.com/id/2727
1943 ABRAHAM, Sir Edward Penley (1913 – 1999); CHAIN, Sir Ernst Boris (1906 – 1979); ROBINSON, Sir Robert (1886 – 1975); ET AL
Penicillamine, a characteristic degradation product of penicillin.
With W. Baker.
GMN 1934.2 · https://historyofmedicine.com/id/2786
1943 FAGET, Guy Henry (1891 – 1947); ET AL
The promin treatment of leprosy. A progress report.
Promin (sodium glucosulphone) introduced in the treatment of leprosy. With R. C. Pogge, F. A. Johansen, J. F. Dinan, B. M. Prejean, and C. G. Eccles.
GMN 2441 · https://historyofmedicine.com/id/2921
1943 MAHONEY, John Friend (1889 – 1957); ARNOLD, Richard C. (1906 – 1992); HARRIS, Ad
Penicillin treatment of early syphilis. A preliminary report.
Mahoney and colleagues introduced penicillin in treatment of syphilis. This was the report of the first four cases of patients with early stages of the disease. Digital facsimile of the version published in the the Am…
GMN 2418 · https://historyofmedicine.com/id/3422
1943 HERRELL, Wallace Edgar (1909 – 1992); ET AL
Use of penicillin in sulfonamide resistant gonorrheal infections.
With E. N. Cook and L. Thompson.
GMN 5214.1 · https://historyofmedicine.com/id/7820
1944 ROSENBERG, David Harry (1903 – ); ARLING, Philip Arthur (1908 – 1955)
Penicillin in the treatment of meningitis.
GMN 4689.1 · https://historyofmedicine.com/id/970
1944 DODD, Matthew Charles (1910 – 1981); STILLMAN, William Barlow (1904 – 1987)
The in vitro bacteriostatic action of some simple furan derivatives.
Nitrofuran (nitrofurazone).
GMN 1928.2 · https://historyofmedicine.com/id/2729
1944 SCHATZ, Albert (1920 – 2005); WAKSMAN, Selman Abraham (1888 – 1973); GREGORY, Elizabeth Bugie
Streptomycin, a substance exhibiting antibiotic activity against Grampositive and Gram-negative bacteria.
Introduction of streptomycin. Order of authorship: Schatz, Gregory, Waksman. In 1952 Waksman was awarded the Nobel Prize in Physiology or Medicine "for ingenious, systematic, and successful studies of the soil microbe…
GMN 1935 · https://historyofmedicine.com/id/2788
1944 MUIR, Ernest (1880 – 1974)
Preliminary report on diasone in the treatment of leprosy.
Muir found diasone (a sulphone) valuable in the treatment of leprosy.
GMN 2442 · https://historyofmedicine.com/id/2923
1944 HADDOW, Sir Alexander (1907 – 1976); ET AL
Influence of synthetic oestrogens upon advanced malignant disease.
Administration of synthetic estrogens in advanced mammary cancer caused regression of tumors. With J. M. Watkinson, E. Paterson, and P. C. Koller.
GMN 2659.3 · https://historyofmedicine.com/id/3355
1944 FLEMING, Sir Alexander (1881 – 1955)
Micro-methods of estimating penicillin blood serum and other bodily fluids.
Fleming was the first to measure blood levels of penicillin after intramuscular, intradermal, inravenous and continuous drip administration in order to determine the correct dosage. He described his micro-measurement …
GMN 12598 · https://historyofmedicine.com/id/14838
1944 FLEMING, Sir Alexander (1881 – 1955); SUCHET, Jack (1908 – 2001); ET AL
Penicillin content of blood serum after various doses of penicillin by various routes.
In this paper Fleming and colleagues explained how to choose routes of administration of penicillin as well as dosage, and reproduced the graphs/figures that showed blood levels achieved with different doses and route…
GMN 12599 · https://historyofmedicine.com/id/14839
1945 TAYLOR, Norman (1883 – 1967)
Cinchona in Java: The story of quinine.
GMN 2061 · https://historyofmedicine.com/id/2330
1945 CHRISTENSEN, Lauritz Royal (1915 – 1997)
Streptococcal fibrinolysis. A proteolytic reaction due to a serum enzyme activated by streptococcal fibrinolysin.
Purification and concentration of Tillett and Garner’s (No. 1924.1) substance to produce streptokinase.
GMN 1928.4 · https://historyofmedicine.com/id/2733
1945 SNYDER, Marshall Lovejoy (1907 – 1969); ET AL
Effectiveness of a nitrofuran in the treatment of infected wounds.
First clinical use of “furacin” (nitrofuran). With C. L. Kiehn and J. W. Christopherson.
GMN 1929.1 · https://historyofmedicine.com/id/2738
1945 JOHNSON, Balbina A. (1897 – 1970); ET AL
Bacitracin: a new antibiotic produced by a member of the B, subtilis group.
With H. Anker and F. L. Meleney.
GMN 1936 · https://historyofmedicine.com/id/2789
1945 FELDMAN, William Hugh (1892 – 1974); HINSHAW, Horton Corwin (1902 – 2001)
Streptomycin in treatment of clinical tuberculosis: a preliminary report.
GMN 2350 · https://historyofmedicine.com/id/3125
1945 CURD, Francis Henry Swinton (1909 – 1948); ET AL
Studies on synthetic antimalarial drugs.
F. H. S. Curd, D. G. Davey, and F. L. Rose synthesized proguanil (“paludrine”) and first tested it in avian malaria.
GMN 5260 · https://historyofmedicine.com/id/8545
1945 ADAMS, Alfred Robert Davies (1901 – 1992)
Studies on synthetic antimalarial drugs. XIII. Results of a preliminary investigation of the therapeutic action of 4888 (paludrine) on acute attacks of benign tertian malaria.
First use of proguanil in human malaria. With B. G. Maegraith, J. D. King, R. H. Townsend, T. H. Davey, and R. E. Havard.
GMN 5261 · https://historyofmedicine.com/id/8546
1945 THORNDIKE, Lynn (1882 – 1965); RUFINUS (1250 – )
The herbal of Rufinus. Edited from the unique manuscript by Lynn Thorndike, assisted by Francis S. Benjamin, Jr.
First printed edition of an herbal written circa 1287 by Rufinus, a medieval monk / physician unknown before this edition. Rufinus was titular abbot in absentia of the monastery of Tyre, and plenipotentiary to the arc…
GMN 12618 · https://historyofmedicine.com/id/14858
1945 ROÍG Y MESA, Juan Tomás (1877 – 1971)
Plantas medicinale aromaticas o venenosas de Cuba. 2 vols.
GMN 13061 · https://historyofmedicine.com/id/15313
1946 DOMAGK, Gerhard Johannes Paul (1895 – 1964); ET AL
Ueber eine neue, gegen Tuberkelbazillen in vitro wirksame Verbindungsklasse.
Introduction of thiosemicarbazone in treatment of tuberculosis. With R. Behnisch, F. Mietzsch, and H. Schmidt.
GMN 2351 · https://historyofmedicine.com/id/3129
1946 HART, Philip Montagu D'Arcy (1900 – 2006)
Chemotherapy of tuberculosis. Researches during the past 100 years.
GMN 2359 · https://historyofmedicine.com/id/3167
1946 MOST, Harry (1907 – 1994); LONDON, Irving M. (1918 – 2018); LAVIETES, Paul Harold (1907 – 1990)
Chloroquine for treatment of acute attacks of vivax malaria.
Harry Most led the development of chloroquine for use in treating American troops suffering from malaria. At the beginning of the American involvement in the war there were more American casualties from malaria than f…
GMN 5261.1 · https://historyofmedicine.com/id/8547
1946 FLEMING, Sir Alexander (1881 – 1955)
Penicillin: Its practical application. Edited by Sir Alexander Fleming.
This was the only book that Fleming ever published on penicillin. American issue, Philadelphia: Blakiston, 1946.
GMN 12623 · https://historyofmedicine.com/id/14863
1947 AINSWORTH, Geoffrey Clough (1905 – 1998); ET AL
“Aerosporin”, an antibiotic produced by Bacillus aerosporus Greer.
Discovery of aerosporin (polymyxin). With A. M. Brown and G. Brownlee.
GMN 1937 · https://historyofmedicine.com/id/2791
1947 EHRLICH, John (1907 – 1992); ET AL
Chloromycetin, a new antibiotic from a soil actinomycete.
Production of chloramphenicol from Streptomyces venezuelae. With Q. R. Bartz, R. M. Smith, D. A. Joslyn and P. R. Burkholder.
GMN 1938 · https://historyofmedicine.com/id/2792
1947 HERRELL, Wallace Edgar (1909 – 1992); HEILMAN, Fordyce Russell (1905 – 1960); ET AL
Procaine penicillin G (duracillin); a new salt of penicillin which prolongs the action of penicillin.
Procaine benzylpenicillin also known as penicillin G procaine was developed by Herrell and colleagues. With D.R. Nichols.
GMN 1939 · https://historyofmedicine.com/id/2793
1947 STANSLY, Philip Gerald (1912 – 1998); ET AL
Polymyxin: a new chemotherapeutic agent.
With R. G. Shepherd and H. J. White.
GMN 1941 · https://historyofmedicine.com/id/2795
1947 HEWITT, Reginald Irving (1911 – ); ET AL
Experimental chemotherapy of filariasis. III. Effect of 1-diethylcarbamyl-4-methyl-piperazine hydrochloride against naturally acquired filarial infections in cotton rats and dogs.
Proof of antifilarial action of diethylcarbarmazine citrate (hetrazan). With S. Kushner, H. W. Stewart, E. White, W. S. Wallace, and Y. Subbarow.
GMN 5351.3 · https://historyofmedicine.com/id/6884
1947 VAN HOOF, L.
Sur la chimiothérapie de l’onchocercose. (Note préliminaire).
First effective chemotherapy (suramin) for onchocerciasis. With C. Heurard, E. Peel, and M. Wanson.
GMN 5351.4 · https://historyofmedicine.com/id/6887
1947 SMADEL, Joseph Edwin (1907 – 1963); JACKSON, Elizabeth B.
Chloromycetin, an antibiotic with chemotherapeutic activity in experimental rickettsial and viral infections.
Introduction of chloramphenicol, used in treatment of typhus.
GMN 1940 · https://historyofmedicine.com/id/8617
1947 SCHULLIAN, Dorothy May (1906 – 1989); POL, Nicolaus (1467 – 1532); FISCH, Max Harold (1900 – 1995)
Nicolaus Pol Doctor 1494 by Max H. Fisch. With a critical text of his guaiac tract, edited with a translation by Dorothy M. Schullian.
The 1494 in the title comes from the year in which Pol became a physician, and his habit of writing his name and that date in his books. The volume includes a study of books from Nicolaus Pol's library in Cleveland an…
GMN 6940 · https://historyofmedicine.com/id/9105
1947 CURTIN, Leonora Scott Muse (1879 – 1972); MOORE, Michael Roland Shaw (1941 – 2009)
Healing herbs of the upper Rio Grande.
Revised and edited by Michael Moore as Healing herbs of the upper Rio Grande: Traditional medicine of the Southwest (Sante Fe: Western Edge Press, 1997).
GMN 9343 · https://historyofmedicine.com/id/11525
1947 MAEHLER, Richard R.
Physicians' desk reference to pharmaceutical specialties and biologicals. Richard R. Maehler, Editor of Compilation and Arrangement.
This work underwent its 71st edition in 2017.
GMN 13043 · https://historyofmedicine.com/id/15294
1947 PAREDES BORJA, Virgilio (1858 – 1983)
La contribución del Ecuador a la material médica: La quina.
GMN 13496 · https://historyofmedicine.com/id/15771
1948 HALD, Jens
The sensitizing effect of tetraethylthiuramdisulphide (Antabuse) to ethyl alcohol.
Introduction of “antabuse” in the treatment of alcoholism. With E. Jacobsen and V. Larsen. See also Lancet, 1948, 2, 1004.
GMN 2091 · https://historyofmedicine.com/id/2572
1948 AHLQUIST, Raymond Perry (1914 – 1983)
A study of the adrenotropic receptors.
Described the concept of α and β adrenergic receptors in the sympathetic nervous system, and placed specific receptors into pharmacologic mechanisms.
GMN 1929.4 · https://historyofmedicine.com/id/2745
1948 BROTZU, Giuseppe (1895 – 1976)
Ricerche su di un nuovo antibiotico.
Brotzu showed that a Cephalosporium acremonium filtrate inhibited the growth of Gram-positive and -negative organisms.
GMN 1943 · https://historyofmedicine.com/id/2802
1948 HARKNESS, Arthur Herbert (1889 – 1970); BROWNLEE, G
Leprosy treated with sulphetrone in 1943.
Clinical use of solapsone (sulphetrone).
GMN 2442.1 · https://historyofmedicine.com/id/2925
1948 FARBER, Sidney (1903 – 1973)
Temporary remissions in acute leukemia in children produced by folic acid antagonist 4-amethopteroylglutamic acid (aminopterin).
With L. K. Diamond, R. D. Mercer, R. F. Sylvester, and V. A. Wolff.
GMN 2660.1 · https://historyofmedicine.com/id/3370
1948 CHRISTIE, Ronald Victor (1902 – 1986)
Penicillin in subacute bacterial endocarditis. Report to the Medical Research Council on 269 patients treated in 14 centres appointed by the Penicillin Clinical Trials Committee.
GMN 2880 · https://historyofmedicine.com/id/4224
