1884 KRÖNLEIN, Rudolph Ulrich (1847 – 1910)
Ueber Lungenchirurgie.
Resection of portion of a lobe that was invaded by sarcoma of the rib.
GMN 3174.1 · https://historyofmedicine.com/id/4162
1884 THOMPSON, Sir Henry (1820 – 1904)
On tumours of the bladder.
Includes description of Thompson’s operation for tumors of the bladder.
GMN 4180 · https://historyofmedicine.com/id/6078
1884 GRAWITZ, Paul Albert (1850 – 1932)
Die Entstehung von Nierentumoren aus Nebennierengewebe.
An important investigation of the origin of hypernephroma (“Grawitz tumor”). See also Arch. klin. Chir., 1884, 30, 824-34.
GMN 4220 · https://historyofmedicine.com/id/6305
1885 ARNOLD, Julius (1835 – 1915)
Untersuchungen über staubinhalation und staubmetastase.
On the effects of dust inhalation. Digital facsimile from the Internet Archive at this link.
GMN 10383 · https://historyofmedicine.com/id/12575
1886 MIKULICZ-RADECKI, Jan (Johann Freiherr von) (1850 – 1905)
Ein Fall von Resection des carcinomatösen Oesophagus mit plastischem Ersatz des excidierten Stückes.
Von Mikulicz was the first to make a plastic reconstruction of the oesophagus after the resection of its cervical portion for carcinoma.
GMN 3487 · https://historyofmedicine.com/id/3881
1886 FRÄNKEL, Felix
Ein Fall von doppelseitigem, völlig latent verlaufenen Nebennieren-tumor und gleichzeitiger Nephritis mit Veränderungen am Circulationsapparat und Retinitis.
Pheochromocytoma first described. Republished in book form.
GMN 3865 · https://historyofmedicine.com/id/4915
1886 PÉAN, Jules-Émile (1830 – 1898)
Ablation des tumeurs flbreuses ou myomes du corps de l’utérus par la voie vaginale.
Péan’s method of morcellement of the uterus for the removal of tumors.
GMN 6084 · https://historyofmedicine.com/id/7487
1887 KRASKE, Paul (1851 – 1930)
Die sacrale Methode der Exstirpation von Mastdarmkrebsen und die Resectio recti.
Kraske introduced the sacral method of resection of the rectum for carcinoma.
GMN 3490 · https://historyofmedicine.com/id/3889
1887 FRÄNKEL, Bernhard (1836 – 1911)
Erste Heilung eines Larynx-Cancroids vermittelst Ausrottung per vias naturales.
First successful intralaryngeal extirpation of a malignant growth.
GMN 3296 · https://historyofmedicine.com/id/4209
1888 BRAMWELL, Sir Byrom (1847 – 1931)
Intracranial tumours.
GMN 4574 · https://historyofmedicine.com/id/444
1888 WEHR, V
Demonstration der durch Impfung von Hund auf Hund erzeugten Carcinomknötchen.
A tumor transplant from dog to dog was reported by Wehr.
GMN 2620.2 · https://historyofmedicine.com/id/3147
1888 BARD, Louis (1857 – 1930); PIC, Adrien (1862 – )
Contribution à l’étude clinique et anatomo-pathologique du cancer primitif du pancréas.
“Bard-Pic syndrome” first described.
GMN 3630 · https://historyofmedicine.com/id/4587
1889 HANAU, Arthur Nathan (1858 – 1900)
Erfolgreiche experimentelle Uebertragung von Carcinom.
Hanau successfully transplanted cancer in mammals.
GMN 2621 · https://historyofmedicine.com/id/3150
1889 KAHLER, Otto (1849 – 1893)
Zur Symptomatologie des multiplen Myeloms.
“Kahler’s disease” – multiple myeloma.
GMN 4351 · https://historyofmedicine.com/id/5753
1889 SENN, Nicholas (1844 – 1908)
Experimental surgery.
Senn made important experimental studies on air embolism, introduced a method of diagnosing intestinal perforation by means of insufflation of hydrogen (see No. 3494), and used X-rays in the treatment of leukemia. He …
GMN 5620 · https://historyofmedicine.com/id/7166
1890 RUSSELL, William (1852 – 1940)
An address on a characteristic organism of cancer.
“Russell’s bodies.”
GMN 2622 · https://historyofmedicine.com/id/3155
1891 EHRLICH, Paul (1854 – 1915)
Farbenanalytische Untersuchungen zur Histologie und Klinik des Blutes.
Extension of Ehrlich’s work on the differential blood count. By means of his methods of staining blood cells Ehrlich differentiated two types of leukemia, lymphatic and myelogenous.
GMN 3069.1 · https://historyofmedicine.com/id/928
1891 MORAU, Henri (1860 – )
Inoculation en série d’une tumeur épithéliale de la souris blanche.
In 1889 Morau transferred epitheliomata in mice and by 1893 had carried his experiments through 17 generations, the first systematic survey of tumor-host relationships from a purely biological viewpoint.
GMN 2622.1 · https://historyofmedicine.com/id/3159
1891 MARCHAND, Felix Jacob (1846 – 1928)
Ueber eine Geschwulst der sogen. Glandula carotica oder des Nodulus caroticus. In Festschrift Rudolf Virchow, 1, 547-54.
First account of the pathology of carotid body tumors.
GMN 3791 · https://historyofmedicine.com/id/4714
1892 BLOCH, Oscar Thorvald (1847 – 1926)
Om extra-abdominal Behandlung af cancer intestinalis (rectum derfra undtaget) med en Fremstilling af de for denne Sygdom foretagne Operationer og deres Resultater.
Bloch was first to employ the two-stage (Mikulicz) operation for cancer of the colon. See also No. 3527.
GMN 3502 · https://historyofmedicine.com/id/3921
1892 DRESCHFELD, Julius (1845 – 1907)
Clinical lecture on acute Hodgkin’s disease
Dreschfeld preceded Kundrat in differentiating Hodgkin’s disease and lymphosarcoma.
GMN 3772 · https://historyofmedicine.com/id/4659
1893 KUNDRAT, Hans (1845 – 1893)
Ueber Lympho-Sarkomatosis.
Kundrat separated lymphosarcoma (“Kundrat’s disease”) from other malignant tumors involving the lymphatic system.
GMN 2623 · https://historyofmedicine.com/id/3163
1893 FRANK, Rudolf (1862 – 1913)
Eine neue Methode der Gastrostomie bei Carcinoma oesophagi.
See No. 3512.
GMN 3508 · https://historyofmedicine.com/id/3966
1893 SÄNGER, Max (1853 – 1903)
Ueber Sarcoma uteri deciduo-cellulare und andere deciduale Geschwülste.
A detailed classification of “deciduomata”, chorionic neoplasms, and a review of the literature.
GMN 6094 · https://historyofmedicine.com/id/7512
1894 AXENFELD, Karl Theodor Paul Polykarpos (1867 – 1930)
Ueber die eitrige metastatische Ophthalmie, besonders ihre Aetiologie und prognostische Bedeutung.
Classic account of metastatic ophthalmia.
GMN 5938 · https://historyofmedicine.com/id/6897
1894 –1895 HALSTED, William Stewart (1852 – 1922)
The results of operations for the cure of cancer of the breast performed at the Johns Hopkins Hospital from June, 1889, to January, 1894.
Halsted’s operation invariably excised the pectoralis major muscle in radical mastectomy. His operation, modified by the retention of the pectoral muscles, remains the cornerstone of surgical treatment of carcinoma of…
GMN 5640 · https://historyofmedicine.com/id/7262
1894 OSLER, Sir William (1849 – 1919)
Lectures on the diagnosis of abdominal tumors. Reprinted from the New York Medical Journal.
This 165-page "monograph, based on lectures delivered to the postgraduate class at the Johns Hopkins Hospital in 1893, includes 67 case reports and 43 illustrations, some of which are photographs that depict patients …
GMN 11652 · https://historyofmedicine.com/id/13853
1895 REHN, Ludwig (1849 – 1930)
Blasengeschwülste bei Fuchsin-Arbeitem.
Rehn noted the frequent appearance of papilloma and carcinoma of the bladder among men employed in the aniline dye industry.
GMN 2128.1 · https://historyofmedicine.com/id/2659
1895 KAHLDEN, Clemens von (1859 – 1903)
Ueber eine eigenthümliche Form des Ovarial carcinoms.
Granulosa cell tumor first described.
GMN 6097 · https://historyofmedicine.com/id/7521
1895 MARCHAND, Felix Jacob (1846 – 1928)
Über die sogenannten “decidualen” Geschwülste im Anschluss an normale Geburt, Abort, Blasenmole und Extrauterinschwangerschaft.
Marchand’s theory of the histogenesis of choriocarcinoma (chorionepithelioma). He considered that such tumors derived from trophoblast and not from decidua.
GMN 6097.1 · https://historyofmedicine.com/id/7522
1895 WILLIAMS, John Whitridge (1866 – 1931)
Deciduoma malignum.
First case of choriocarcinoma reported in North America.
GMN 6100 · https://historyofmedicine.com/id/7529
1896 BECQUEREL, Antoine Henri (1852 – 1908)
Sur les radiations émises par phosphorescence.
The discovery of radioactivity – research stimulated by Roentgen’s discovery of x rays. In 1903 Becquerel received half of the Nobel Prize in Physics 1903 "in recognition of the extraordinary services he has rendered …
GMN 2001 · https://historyofmedicine.com/id/4181
1896 BEATSON, Colonel Sir George Thomas (1848 – 1933)
On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment, with illustrative cases.
Öophorectomy in the treatment of breast cancer.
GMN 5778.1 · https://historyofmedicine.com/id/6824
1896 KRUKENBERG, Friedrich Ernst (1870 – 1946)
Ueber das Fibrosarcoma ovarii mucocellulare (carcinomatodes).
Original description of “Krukenberg’s tumor”.
GMN 6101 · https://historyofmedicine.com/id/7531
1897 MCBRIDE, Peter (1854 – 1946)
Photographs of a case of rapid destruction of the nose and face.
Malignant granuloma of the nose first described.
GMN 3309.1 · https://historyofmedicine.com/id/4515
1897 PALTAUF, Richard (1858 – 1924)
Lymphosarkom (Lymphosarkomatose, Pseudoleukämie, Myelom, Chlorom).
“Paltauf-Sternberg disease” (see also No. 3776). On the European Continent the name “Hodgkin-Paltauf-Sternberg disease” is in use.
GMN 3775 · https://historyofmedicine.com/id/4668
1898 CURIE, Pierre (1859 – 1906); CURIE, Marie Sklodowska (1867 – 1934)
Sur une substance nouvelle radio-active, contenue dans la pechblende.
The Curies, studying the radioactivity of minerals containing uranium and thorium, isolated from pitchblend a substance which they called radium and which they showed to possess an astonishing degree of radioactivity.…
GMN 2003 · https://historyofmedicine.com/id/1914
1898 STERNBERG, Carl (1872 – 1935)
Ueber eine eigenartige, unter dem Bilde der Pseudoleukämie verlaufende Tuberkulose des lymphatischen Apparates.
In his classic description of lymphadenoma, Sternberg separated it from aleukemic leukemia, with which it had hitherto been included.
GMN 3776 · https://historyofmedicine.com/id/4672
1898 FABRE-DOMERGUE, Paul-Louis (1861 – 1940)
Les cancers épithéliaux. Histologie - Histogenèse - Etiologie - Applications thérapeutiques.
GMN 11152 · https://historyofmedicine.com/id/13349
1899 SJÖGREN, Tage Anton Ultimus (1859 – 1939)
Fall af epiteliom behandladt med Roentgenstraler.
In June 1899 Sjögren was the first successfully to use Roentgen rays in the treatment of cancer.
GMN 2624 · https://historyofmedicine.com/id/3170
1899 HALSTED, William Stewart (1852 – 1922)
Contribution to the surgery of the bile passages, especially of the common bile-duct.
“Among Halsted’s many outstanding surgical accomplishments those related to surgery of the biliary tract are lesser known. However, he is commonly credited with performing the first successful operation for a primary …
GMN 3639.1 · https://historyofmedicine.com/id/4642
1899 WILMS, Carl Max Wilhelm (1867 – 1918)
Die Mischgeschwülste. I. Die Mischgeschwülste der Niere.
Embryoma of the kidney (“Wilms’s tumor”). For the history of the operation for Wilms’s tumor see B. Thomasson and M.M. Ravitch, Wilms Tumor, Urol. Surg., 1961, 11, 83-100.
GMN 4227 · https://historyofmedicine.com/id/5058
1899 ORTHMANN, Ernst Gottlob (1858 – 1922)
Zur Casuistik einiger seltenerer Ovarial- und Tuben-Tumoren.
“Brenner tumor” first described; see also No. 6118.
GMN 6109.1 · https://historyofmedicine.com/id/7548
1900 BENDA, Carl (1857 – 1933)
Beiträge zur normalen und pathologischen Histologie der menschlichen Hypophysis cerebri.
Benda showed that the pituitary tumor in acromegaly consists of chromophil cells.
GMN 3888 · https://historyofmedicine.com/id/4950
1900 CULLEN, Thomas Stephen (1868 – 1953)
Cancer of the uterus: Its pathology, symptomatology, diagnosis, and treatment. Also the pathology of diseases of the endometrium.
Includes first clinical and pathological study of hyperplasia of the endometrium. Cullen is remembered eponymically for “Cullen’s sign”, a discoloration of the skin about the umbilicus, regarded as a sign of ruptured …
GMN 6110 · https://historyofmedicine.com/id/7550
1900 WERTHEIM, Ernst (1864 – 1920)
Zur Frage der Radical operation beim Uteruskrebs.
Wertheim’s radical operation for cancer of the uterus.
GMN 6114 · https://historyofmedicine.com/id/7557
1900 OSLER, Sir William (1849 – 1919); MCCRAE, Thomas (1870 – 1935)
Cancer of the stomach: A clinical study.
This was Osler's first collaboration with Thomas McCrae. Osler and McCrae reviewed 150 cases of cancer of the stomach seen at Johns Hopkins in an encyclopedic fashion. Surgery was often recommended for definitive diag…
GMN 11289 · https://historyofmedicine.com/id/13486
1901 LOEB, Leo (1869 – 1959)
On transplantation of tumours.
Loeb successfully transplanted cystic sarcoma of the thyroid in rats. He established the fact that growth of the transplant occurred through proliferation of its peripheral cells.
GMN 2624.1 · https://historyofmedicine.com/id/3174
1901 BEHLA, Robert Franz (1850 – 1921)
Die Carcinomlitteratur. Eine Zusammenstellung der in-und ausländischen Krebsschriften bis 1900.
GMN 2661 · https://historyofmedicine.com/id/3443
1901 PEPPER, William Jr. (1843 – 1898)
A study of congenital sarcoma of the liver and suprarenal. With report of a case.
Pepper’s type of adrenal medullary tumor.
GMN 3866 · https://historyofmedicine.com/id/4917
