1860 NIEMANN, Albert (1834 – 1861)
Ueber eine neue organische Base in den Cocablättern.
Isolation of cocaine, 1859, from the coca leaf, brought from Peru by Scherzer.
GMN 1865 · https://historyofmedicine.com/id/2423
1868 MORÉNO Y MÄIZ, Tomás
Recherches chimiques et physiologiques sur l’erythroxylum coca du Pérou et la cocaïne.
The author, formerly a surgeon in the Peruvian army, issued the first study of the pharmacological action of cocaine, containing the earliest suggestion of its use as a local anesthetic. Leclerc issued the commercial …
GMN 1868 · https://historyofmedicine.com/id/2451
1880 ANREP, Vasili Konstantinovich (1852 – 1927)
Ueber die physiologische Wirking des Cocaïn.
Anrep studied the action of cocaine and, like Moréno y Maïz, suggested that it might be used as a local anesthetic.
GMN 1871 · https://historyofmedicine.com/id/2470
1884 FREUD, Sigmund (1856 – 1939)
Ueber coca.
Freud described his observations (with himself as subject) on the effects of cocaine, including its abolition of hunger and fatigue, the “exhilaration and lasting euphoria”. He also described its supposed non-addictiv…
GMN 1880.1 · https://historyofmedicine.com/id/2515
1884 JELINEK, Edmund (1852 – 1928)
Das Cocain als Anästheticum und Analgeticum für den Pharynx und Larynx.
Cocaine first employed in laryngology.
GMN 3292 · https://historyofmedicine.com/id/4199
1884 KOLLER, Carl (1857 – 1944)
Vorläufige Mitteilung über locale Anästheserung am Auge.
Introduction of cocaine as a local anesthetic; this was the first local anesthetic employed (16 September 1884). Freud (No. 1880.1) is accredited by some with this innovation, but in this connection see the letter by …
GMN 5678 · https://historyofmedicine.com/id/7365
1884 KOLLER, Carl (1857 – 1944); KNAPP, Jacob Hermann (1832 – 1911)
On cocaine and its use in ophthalmic and general surgery.
Knapp translated Koller's paper (No. 5678) into English and with the English translation published a large amount of supplementary material by American surgeons who had recently experimented with cocaine as a local an…
GMN 8655 · https://historyofmedicine.com/id/10832
1885 HALSTED, William Stewart (1852 – 1922)
Practical comments on the use and abuse of cocaine; suggested by its invariably successful employment in more than a thousand minor surgical operations.
The first experiments on local infiltration anesthesia were made by Halsted, who even produced anesthesia by the intradermal injection of water. Through the process of self-experimentation Halsted became addicted to c…
GMN 5679 · https://historyofmedicine.com/id/7369
1885 CORNING, James Leonard (1855 – 1923)
Spinal anaesthesia and local medication of the cord.
Spinal anesthesia introduced. Corning showed experimentally that cocaine exerts a prolonged anesthetic effect while arresting the circulation in the anesthetized area. He first described injection of cocaine between t…
GMN 5680 · https://historyofmedicine.com/id/7371
1890 PERNICE, Ludwig; OBERST, Maximilian (1849 – 1925)
Ueber Cocainanasthesie.
Maximilian Oberst’s method of conduction anesthesia was first reported by Pernice, his pupil.
GMN 5681 · https://historyofmedicine.com/id/7378
1895 RECLUS, Jean Jacques Paul (1847 – 1914)
La cocaine en chirurgie.
The first French book on local anesthesia.
GMN 12876 · https://historyofmedicine.com/id/15123
1899 BIER, August Karl Gustav (1861 – 1949)
Versuche über Cocainisirung des Rückenmarkes.
Bier introduced the use of cocaine as a spinal anesthetic.
GMN 5684 · https://historyofmedicine.com/id/7392
1901 CRILE, George Washington (1864 – 1943)
An experimental and clinical research into certain problems relating to surgical operations.
Crile made important contributions to knowledge regarding shock. He originated the theory that it is due to exhaustion of the vasomotor center. (See also No. 5629.) Chapter V: On the physiologic action of cocain and e…
GMN 5624 · https://historyofmedicine.com/id/7198
1902 CUSHING, Harvey Williams (1869 – 1939)
On the avoidance of shock in major amputations by cocainization of large nerve-trunks preliminary to their division.
William S. Halsted was first to use infiltration anesthesia (see No. 5679) and it was later developed by Cushing.
GMN 5689 · https://historyofmedicine.com/id/7419
