1945 CHRISTENSEN, Lauritz Royal (1915 – 1997)
Streptococcal fibrinolysis. A proteolytic reaction due to a serum enzyme activated by streptococcal fibrinolysin.
Purification and concentration of Tillett and Garner’s (No. 1924.1) substance to produce streptokinase.
GMN 1928.4 · https://historyofmedicine.com/id/2733
1945 COMLY, Hunter Hall (1919 – )
Cyanosis in infants caused by nitrates in well water.
Methemoglobinemia. Comly first suggested the above hypothesis, since proved valid.
GMN 3103 · https://historyofmedicine.com/id/3799
1945 COOMBS, Robert Royston Amos ( (1921 – 2006); ET AL
Detection of weak and “incomplete” Rh agglutinins: a new test.
Coombs’s test for detecting antibodies in various clinical scenarios, such as Rh disease and blood transfusion. With A. E. Mourant and R. R. Race. A fuller description appears in Brit. J. exp. Path.,1945, 26, 255-66.
GMN 3104 · https://historyofmedicine.com/id/3805
1945 WIENER, Alexander Solomon (1907 – 1976)
Conglutination test for Rh sensitization.
Conglutination test.
GMN 3105 · https://historyofmedicine.com/id/3808
1945 SPIES, Tom Douglas (1902 – 1960); ET AL
Observations of the anti-anemic properties of synthetic folic acid.
Hemopoietic properties of folic acid reported. With C. F. Vilter, M. B. Koch, and M. H. Caldwell.
GMN 3150 · https://historyofmedicine.com/id/4002
1946 PATERSON, Edith (1900 – 1995); ET AL
Leukaemia treated with urethane compared with deep x-ray therapy.
Urethane in treatment of leukemia. With A. Haddow, I. Ap Thomas, and J. M. Watkinson.
GMN 3106 · https://historyofmedicine.com/id/3811
1946 ANGIER, Robert Crane (1917 – )
The structure and synthesis of liver. L. casei factor.
Isolation, determination of structure, and final synthesis of folic acid.
GMN 3151 · https://historyofmedicine.com/id/4005
1946 GOETSCH, Anne Carlton Tompkins (1917 – 2003); ET AL
Observations on the effect of massive doses of iron given intravenously to patients with hypochromic anemia.
GMN 3152 · https://historyofmedicine.com/id/4008
1947 OWREN, Paul Arnor (1905 – 1990)
The coagulation of blood. Investigations on a new clotting factor.
Discovery of the Factor V. Preliminary account in Proc. Norwegian Acad. Sci., 1941, 17, 21.
GMN 912.5 · https://historyofmedicine.com/id/1085
1947 WALSH, Robert John (1917 – 1983); MONTGOMERY, Carmel M.
A new human iso-agglutinin subdividing the MN blood groups.
S blood-group antigen.
GMN 913 · https://historyofmedicine.com/id/1089
1947 MOURANT, Arthur Ernest (1904 – 1994)
The use of blood groups in anthropology.
GMN 195 · https://historyofmedicine.com/id/3482
1947 SOULIER, Jean Pierre (1913 – 2003); GUEGUEN, Jean
Action hypoprothrombinémiante (anti-K) de la phényl-indanedione étudiée expérimentalement chez le lapin. Son application chez l’homme.
Introduction of phenylindanedione.
GMN 3107 · https://historyofmedicine.com/id/3814
1947 NISSIM, Joseph Abraham
Intravenous administration of iron.
GMN 3153 · https://historyofmedicine.com/id/4011
1948 SMITH, Ernest Lester (1904 – 1992)
Presence of cobalt in the anti-pernicious anaemia factor.
Independently of Rickes et al., Lester Smith isolated vitamin B12 in Britain. See also Nature (Lond.), 1948, 161, 638.
GMN 1092 · https://historyofmedicine.com/id/875
1948 DIAMOND, Louis Klein (1902 – 1999)
Replacement transfusion as a treatment for erythroblastosis fetalis.
Exchange transfusion.
GMN 3107.1 · https://historyofmedicine.com/id/3816
1948 GIBSON, Quentin Howieson (1918 – 2011)
The reduction of methaemoglobin in red blood cells and studies on the cause of idiopathic methaemoglobinaemia.
Cause of hereditary methemoglobinemia elucidated.
GMN 3107.2 · https://historyofmedicine.com/id/3819
1948 REINIS, Z; KUBIK, Mirko
Klinische Erfahrungen mit einem neuen Präparat der Cumarinreihe.
Introduction of ethyl biscoumacetate (“tromexan”).
GMN 3108 · https://historyofmedicine.com/id/3823
1948 WEST, Randolph (1890 – )
Activity of vitaminB12 in Addisonian pernicious anemia.
First demonstration of the effectiveness of vitamin B12 in pernicious anemia.
GMN 3154 · https://historyofmedicine.com/id/4013
1949 PAULING, Linus Carl (1901 – 1994); ITANO, Harvey Akio (1920 – 2010); SINGER, Seymour Jonathan (1924 – 2017); WELLS, Ibert C. (1921 – 2011)
Sickle cell anemia, a molecular disease.
First recognition, by Pauling and colleagues, of a structural hemoglobin variant, and the beginning of the molecular approach to disease.
GMN 3154.1 · https://historyofmedicine.com/id/4015
1949 NEEL, James Van Gundia (1915 – 2000)
The inheritance of sickle cell anemia.
Genetic evidence that sickle-cell disease is inherited in a simple Mendelian manner.
GMN 3154.2 · https://historyofmedicine.com/id/4053
1949 UNGLEY, Charles Cady (1902 – 1958)
Vitamin B12 in pernicious anaemia: parenteral administration.
GMN 3155 · https://historyofmedicine.com/id/4054
1952 BIGGS, Rosemary Peyton (1921 – 2001); ET AL
Christmas disease, a condition previously mistaken for haemophilia.
Christmas disease, hemophilia B, due to lack of Factor IX. Named after the patient whose case was the first recorded example. With six co-authors.
GMN 3108.1 · https://historyofmedicine.com/id/3824
1953 BURCHENAL, Joseph Holland (1912 – 2006); ET AL
Clinical evaluation of a new antimetabolite, 6-mercaptopurine, in treatment of leukemia and allied diseases.
Clinical introduction of 6-mercaptopurine in treatment of acute leukemia and chronic myelocytic leukemia. With nine co-authors.
GMN 3108.3 · https://historyofmedicine.com/id/3826
1953 HADDOW, Sir Alexander (1907 – 1976); TIMMIS, Geoffrey Millward
Myleran in chronic myeloid leukaemia: chemical constitution and biological action.
Introduction of myleran (busulphan). For results, see pp. 208-13.
GMN 3108.4 · https://historyofmedicine.com/id/3829
1953 SHAY, Harry (1898 – ); ET AL
Treatment of leukemia with triethylenethiophosphoramide (Thio-TEPA); preliminary results in experimental and clinical leukemia.
With C. Zarafonetis, N. Smith, I. Woldow and D. C. H. Sun.
GMN 3108.5 · https://historyofmedicine.com/id/3830
1955 GALTON, David Abraham Goiten (1922 – 2007)
Clinical trials of p-(DI-2-chloroethylamino)-phenylbutyric acid (CB 1348) in malignant lymphoma.
Clinical use of chlorambucil for chronic lymphatic leukemia. With L. G. Israels, J. D. N. Nabarro, and M. Till.
GMN 3108.6 · https://historyofmedicine.com/id/3831
1957 INGRAM, Vernon Martin (1924 – 2006)
Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin.
Sickle-cell hemoglobin differs from normal hemoglobin by a single amino acid (valine for glutamic acid).
GMN 3155.1 · https://historyofmedicine.com/id/4055
1957 PAYNE, Rose Marise (1909 – )
Leukocyte agglutinins in human sera. Correlations between blood transfusions and their development.
Leucocyte typing.
GMN 2578.23 · https://historyofmedicine.com/id/4239
1959 INGRAM, Vernon Martin (1924 – 2006); STRETTON, Antony Oliver Ward (1936 – )
Genetic basis of the thalassaemia diseases.
GMN 3155.2 · https://historyofmedicine.com/id/4056
1959 LINK, Karl Paul Gerhard (1901 – 1978)
The discovery of Dicumarol and its sequels.
An historical account of the discovery of the anticoagulant Warfarin by the primary investigator. The first use for this substance was rat poison. Digital facsimile from ahajournals.org at this link.
GMN 11405 · https://historyofmedicine.com/id/13604
1961 LOCK, Stephen Penford (1929 – ); ET AL
Stomatocytosis: a hereditary red cell anomaly associated with haemolytic anaemia.
With R. Sephton Smith and R. M. Hardisty.
GMN 3155.3 · https://historyofmedicine.com/id/4090
1963 LILEY, Albert William (1929 – 1983)
Intrauterine transfusion of foetus in haemolytic disease.
GMN 3108.7 · https://historyofmedicine.com/id/3833
1964 FREDA, Vincent J. (1927 – 2003); ET AL
Successful prevention of experimental Rh sensitization in man with an anti-Rh gamma2-globulin antibody preparation.
With J. G. Gorman and W. Pollack.
GMN 3108.8 · https://historyofmedicine.com/id/3836
1966 LEHMANN, Hermann (1910 – 1985); HUNTSMAN, Richard George (1927 – 2015)
Man’s haemoglobins: including the haemoglobinopathies and their investigation.
Explains the current distribution of sickling throughout the world.
GMN 3155.4 · https://historyofmedicine.com/id/4091
1968 ELLISON, Rose Ruth (1923 – 2009); ET AL
Arabinosyl cytosine: A useful agent in the treatment of acute leukemia in adults.
Cytosine arabinoside. With J. P. Holland, M. Weil, et al.
GMN 3108.9 · https://historyofmedicine.com/id/3838
1968 LEHMANN, Hermann (1910 – 1985); PERUTZ, Max Ferdinand (1914 – 2002)
Molecular pathology of human haemoglobin.
Perutz opened up "the field of 'molecular pathology,' relating a structural abnormality to a disease" (Aaron Klug, "Max Perutz 1914-2002," Science 295 ([2002] 2383). Specifically Perutz showed that hemoglobin molecule…
GMN 6916 · https://historyofmedicine.com/id/9081
1973 ZIMMERMAN, David R.
Rh: The intimate history of a disease and its conquest.
GMN 14089 · https://historyofmedicine.com/id/16400
1974 BOROVICZENY, Karl Georg von
Einführung in die Geschichte der Haematologie.
Thirteen contributions edited by Boroviczény, H. Schipperges, and E. Seidler. Includes chronological table of events in the history of medicine and a bibliography.
GMN 3161.4 · https://historyofmedicine.com/id/4103
1974 BESSIS, Marcel (1917 – 1994)
Corpuscles: Atlas of red blood cell shapes.
A spectacular oversize atlas reproducing 121 photographs of erythrocytes as visualized with a scanning electron microscope. The first edition was published in English, followed by an edition in French in 1976.
GMN 11553 · https://historyofmedicine.com/id/13752
1975 HAMBERG, Mats; ET AL
Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.
With J. Stevenson and B. Samuelsson.
GMN 1931.7 · https://historyofmedicine.com/id/2762
1976 MILLER, Louis Howard (1935 – ); MASON, Steven J.; CLYDE, David Francis (1925 – 2002); ET AL
The resistance factor to Plasmodium vivax in blacks.
The authors showed that the Plasmodium vivax parasite requires the Fya/Fyb Duffy antigen/chemokine receptor on the surface of red blood cells for penetration of human red blood cells. Because most African and American…
GMN 11888 · https://historyofmedicine.com/id/14093
1980 WINTROBE, Maxwell Myer (1901 – 1986)
Blood, pure and eloquent. A story of discovery, of people, and of ideas.
A collective work by 19 authors, edited by M. M. Wintrobe. This is a detailed history of haematology, well documented and well indexed.
GMN 3161.5 · https://historyofmedicine.com/id/4106
1985 WINTROBE, Maxwell Myer (1901 – 1986)
Hematology, the blossoming of a science: a story of inspiration and effort.
GMN 3161.7 · https://historyofmedicine.com/id/4110
1990 BIGELOW, Wilfred Gordon (1913 – 2005)
Mysterious heparin: The key to open heart surgery.
GMN 12334 · https://historyofmedicine.com/id/14558
1992 BERNARD, Jean (1907 – 2006); BESSIS, Marcel (1917 – 1994); BINET, Jacques-Louis (1932 – )
Histoire illustrée de l'hematologie: De l'antiquité à nos jours.
GMN 8607 · https://historyofmedicine.com/id/10784
1992 GOTTLIEB, A. Matthew
A pictorial history of blood practices and transfusion.
GMN 13062 · https://historyofmedicine.com/id/15314
2001 OWEN, Charles Archibald Jr. (1915 – 2001)
A history of blood coagulation.
GMN 7101 · https://historyofmedicine.com/id/9268
2016 PIERCE, Stephen R.; REID, Marion E.
Bloody brilliant! A history of blood groups and blood groupers.
GMN 8859 · https://historyofmedicine.com/id/11037
2020 FEDER, Henry M. Jr.; REZUKE, William N.
Infectious mononucleosis diagnosed by Downey cells: Sometimes the old ways are better.
The Downey cell method for the diagnosis of infectious mononucleosis remains effective and cost-effective nearly 100 years after it was discovered: "An 18-year-old woman visited her physician because she had a fever, …
GMN 12117 · https://historyofmedicine.com/id/14326
