This monumental work is a landmark in dermatological history. Sir Norman Walker translated it into English in 1896. Unna, short in stature but a giant among dermatologists, initiated the study of the skin by means of diascopy and gave several original descriptions of affections of the skin. The acne bacillus is described for the first time on p. 357.

An extensive and valuable collection of illustrations in dermatology. Includes 377 chromolithographs.

"In publishing this hand atlas of skin diseases, I wish to provide students with an aid to their studies and general practitioners with a means of comparison and verification when diagnosing skin diseases... The hand atlas not only has to contain all common and unusual forms of diseases, it must also show all of the modifications they can assume according to their site, extensiveness, and phase of development or regression. Our dermatology clinic here at Vienna University has a collection of teaching aids, consisting of coloured original water-colour paintings commissioned by Ferdinand Hebra. These paintings now number almost 1000. Most of them are the masterly work of Elfinger and Karl Heitzmann..." (Quoted by Ehring, Skin Diseases: 5 Centuries of Scientific Illustration [1989] p. 180).

Finsen was a pioneer in the treatment of lupus by means of light. English translation, 1901.

First application of radium in the treatment of lupus.

Sabouraud’s method of radiological treatment of ringworm.

Chaoul therapy.

Introduction of calciferol in the treatment of lupus. A more extensive report, “Le traitement des tuberculoses cutanées par la vitamine D₂ à hautes doses”, appeared in the same journal, 1946, 8 sér., 6, 310-46.

Dowling and Prosser Thomas introduced calciferol in the treatment of lupus independently of Charpy (no. 4010) whose work was unknown to them owing to the wartime isolation of France.

Use of griseofulvin in the treatment of ringworm.

An early history of diseases, with extensive sections on ophthalmology (ff. 66-77) and urology (ff. 260-271). Lib. IV, Cap. iii, page 196 contains the first recorded case of gastric ulcer. Lib. VI. cap. iii contains the first description of angioneurotic edema (later described as Quincke's edema, No. 4081). Digital facsimile from the Medical Heritage Library, Internet Archive at this link.

First clinical and experimental proof of infection by a microparasite. Bonomo observed Sarcoptes scabiei, the scabies mite. This gave researchers grounds to think in terms of objective, exogenous pathogenic agents as the cause of disease. This pamphlet was in part translated by Richard Mead in Phil. Trans.,(1702-03), 1703, 23, 1296-99; it was reproduced in facsimile, with Mead’s translation, in Arch. Derm. Syph. (Chicago), 1928, 18, 1-25. See 2529.1.

First known description of Ichthyosis hystrix, a group of rare skin disorders in the ichthyosis family of skin disorders characterized by massive hyperkeratosis with an appearance like spiny scales. Digital facsimile from the Royal Society at this link.

Machin’s observations referred to the Lambert family, and were followed through successive generations of the family by Henry Baker in "A supplement to the account of a distempered skin, published in the 424th number of the Philosophical Transactions," Phil. Trans., 1755, 49,  21-24. Digital facsimile of Baker's paper from the Royal Society at this link. 

The early history of scleroderma is confused with that of leprosy, ichthyosis, and keloid. Crusio appears to be the first to differentiate it. Gintrac in 1847 coined the term “scleroderma”. It is now included among the connective tissue diseases. Digital facsimile from the Internet Archive at this link.

Underwood laid the foundation of modern pediatrics. His work was superior to anything that had previously appeared and remained the most important book on the subject for sixty years, passing through many editions. The first edition (p.76) includes the first description of sclerema neonatorum (“Underwood’s disease”). That edition also contains a description of "aphthae of thrush."

In the second edition (1789, volume 2, pp. 122-27) Underwood presented a description of congenital heart disease in children. This was the first pediatric treatise to do so. Also, in the second edition, volume 2, pp. 53-57 entitled "Debility of the lower extremities," Underwood was the first to consider poliomyelitis as an entity.

First recorded description of multiple neurofibromatosis. Akenside was better known as a poet;  he was caricatured as the republican doctor of Tobias Smollett's The Adventures of Peregrine Pickle.

Wichmann definitely established the parasitic aetiology of scabies.

Original description of cornu cutaneum.

Modern dermatology may be said to start with Willan. His classification of skin diseases gained him the Fothergillian Medal of the Medical Society of London in 1790. He established a standard nomenclature which is still more or less in use today. He was also a clinician of great ability who made numerous original observations. His book was issued in four parts under the title “Description and treatment of cutaneous diseases”, from 1798 to 1808, and only vol. 1 had been completed when Willan died. The first three parts exist in revised versions. Copies of the book may contain varying states of the parts. See F. Sutherland, Willan’s Cutaneous diseases, J. Hist. Med., 1958, 13, 92-94, supplementing T. Beswick, Robert Willan, J. Hist. Med., 1957, 12, 349-65. The above work and that of Alibert (No. 3986) are the first dermatological works with colored plates. 

Includes (pp. 73-76) original description of prurigo mitis; under the name “ichthyosis cornea” Willan quoted Crusio’s case of scleroderma (see pp. 197-212); Willan also established psoriasis as a separate skin disease (pp. 152-88). 

The largest and most spectacular of the early classics of dermatology, with hand-colored illustrations unsurpassed for their quality of execution. The illustrations are also the first on the subject in a French book. This book also contains the first description of mycosis fungoides (pian fungoide, framboesia mycoides), one of several conditions to which the name of Alibert has been attached.

First description of ecthyma terebrans, “pemphigus gangrenosa”.

This was the most influential textbook of dermatology of the 19th century, and the work which conveyed Willan’s system to most of the medical world. Included in the book was material by Willan which remained unpublished from his unfinished On cutaneous diseases. The Synopsis also “contained material original to Bateman himself…and it also provided insights into the origins of the morphologic system and an appreciation of its limitations not to be found in the work it was designed to complete” (Crissey & Parish). Description of lichen urticatus appears on p. 13.

This treatise on infantile eczema is the only fascicule of the second volume of Willan’s On cutaneous diseases (No.4018) that ever appeared in print. It was edited for publication after Willan's death by his stepson-in-law Ashby Smith.

Bateman, the pupil of Willan, continued his teacher’s classification of skin diseases. The above work is notable for its 72 colored plates. Strictly speaking it is the first atlas of dermatology, as Willan’s work falls more into the category of illustrated treatise. This book includes numerous original contributions by Bateman. Originally issued in 12 fasciculi from 1814-1817. Unchanged reprint, 1828. 

Includes (pl. lii) important description of herpes iris (erythema iris), and of the eczema due to external irritation (pl. lv-lviii, eczema solare, impetiginoides, rubrum mercuriale). Pl. lxi represents the first description of molluscum contagiosum, but according to Paterson (No. 4032) the disease was probably noticed by Tilesius about 1793. Bateman refers to Tilesius but calls his case molluscum pendulum. 

First accurate description of keloid (“Alibert’s keloid”), although it was mentioned by Retz in 1790.

Contains (vol. 2, p. 214) first description of sycosis barbae (“Alibert’s mentagra”).

Arthur Jacob, Professor of Anatomy and physiology in Dublin, described “Jacob’s ulcer”, rodent ulcer attacking the face, especially the eyelid.

Demonstration of the human itch-mite, Sarcoptes scabiei. It was due to Renucci that the Sarcoptes was recognized as the one cause of scabies and its parasitic nature finally accepted.

Laurent Théodore Biett (1781-1840), was a pupil of Alibert, Willan, and Bateman. His classic description of lupus erythematoides migrans (“Biett’s disease”) occurs on pp. 11 and 415 of the above work.

The discovery of a fungus as the cause of favus (Achorion schönleinii). Schönlein communicated this important discovery in a letter of less than 200 words and one illustration. It represents the first conspicuous step in the attribution of disease to the action of minute parasites. Schönlein was the founder of modern clinical teaching in Germany.

Independently of Schönlein (No. 4029) Gruby discovered the achorion of favus, describing it definitely as the cause of the disease, a point about which Schönlein was in doubt.

See No. 4032.

Henderson and Paterson described the inclusion body of molluscum contagiosum, “Henderson–Paterson body”.

Boeck, eminent Norwegian dermatologist and syphilologist, was the first to describe Norwegian itch, scabies crustosa (“Boeck’s scabies”).

First accurate description of Trichophyton mentagrophytes, the fungus responsible for sycosis barbae. English translation of this and Gruby’s other five papers read to l’Académie des Sciences in Zakon & Benedek, David Gruby and the centenary of medical mycology, 1841-1941, Bull. Hist. Med., 1944, 16, 155-68.

First accurate description of Microsporon audouini, the fungus of Willan’s porrigo decalvans, tinea tonsurans, “Gruby’s disease”.

Gruby discovered a fungus, Trichophyton tonsurans, in ringworm of the scalp.

First description of pemphigus foliaceus, “Cazenave’s disease”. The article is unsigned.

Eichstedt discovered Pityrosporum orbiculare, fungus of pityriasis versicolor (“Eichstedt’s disease”).

Lupus erythematosus – “Cazenave’s disease”.

In their classic account of xanthoma multiplex, Addison and Gull believed they were describing a new disease, but Rayer had been the first to mention it. (See No. 3989; see also the later paper by Gull, Guy’s Hosp. Rep., 1852, 2 ser., 8, 149.)

Addison described two forms of keloid, that described by Alibert, and the “true keloid” (the skin disease morphoea, “Addison’s keloid”).

First description of tinea cruris (eczema marginatum, “Bärensprung’s disease”).

Devergie is remembered for his clear description of pityriasis rubra pilaris, (“Devergie’s disease”). He was the first to demonstrate the presence of a fungus in eczema marginatum.

First description of this condition (“Hebra’s pityriasis”).

Chromidrosis first described.

First modern description of mycetoma of the foot – “Madura foot”, “Carter’s mycetoma”. It was mentioned by E. Kaempfer in his Amoenitates exoticae, Lemgo, 1712, p. 561. Colebrook at the Madura Dispensary is said to have given it the name “Madura foot” in 1846. See also No. 4066.

Gibert’s name is associated with pityriasis rosea, which he first established as a definite clinical entity. His complete and accurate description of this condition is on page 402 of vol. 1 of the above work.

Complete description of tinea cruris (eczema marginatum), first described by Bärensprung in 1854.

First description of keratosis follicularis.

Erythema induratum scrophulosorum (“Bazin’s disease”) first described.

First description of lineae atrophicae.

Description of dissecting-room warts (verrucae necrogenicae),tuberculosis verrucosa cutis (also known as Lupus verrucosus, Prosector's wart, and "Warty tuberculosis"^[ the cutaneous tuberculosis of Laennec, sometimes called “Wilks’s disease”.

First recorded case of dermatomyositis, now regarded as a connective tissue disease.

“Impetigo of Tilbury Fox”, impetigo contagiosa, first described.

Colloid degeneration of the skin (“Wagner’s disease”) was first described by Wagner who gave it the name “Colloid milium”.

Poikiloderma congenitale (Rothmund).

Urticaria pigmentosa (Mastocytosis of the skin) described by Nettleship, was named eponymically “Nettleship’s disease”.

Tinea nodosa (trichorrhexis nodosa, “Paxton’s disease”) first described.

First description, tinea imbricata. Turner described the disease while serving as a medical missionary in Samoa.

First description of dermatitis exfoliativa neonatorum (“Rittershain’s disease”).

Although Hippocrates mentioned this condition, Erasmus Wilson first named it and described it as we know it today. It has been called “Wilson’s disease”; an eponym discarded since its use to describe the progressive lenticular degeneration of Kinnier Wilson.

Hebra was the first to describe impetigo herpetiformis, more fully dealt with by Kaposi, his son-in-law.

First description of “Kaposi’s sarcoma” – multiple idiopathic hemorrhagic sarcoma. English translation in CA, 1982, 32, 342-47.

First description of erythema serpens, usually called “erysipeloid of Rosenbach”, following the latter’s paper in Arch. klin. Chir., 1887, 36, 346.

Original description of dysidrosis (pompholyx).

See No. 4047.

Vol. 1 pp. 49-52: Hutchinson’s classic description of cheiropompholyx, dysidrosis (“Hutchinson’s disease”). The first description and illustration of sarcoidosis is on p. 42.

First description of porokeratosis (Mibelli).

First description of the condition called by Herxheimer and Hartmann in 1902 “acrodermatitis chronica atrophicans”, and known eponymically as “Taylor’s disease”.

Although Quincke described angioneurotic edema with great precision and has given his name to it (“Quincke’s disease”, “Quincke’s edema”), Milton first noted it, calling it “giant urticaria”.

“Koebner phenomenon” – appearance at points of injury of any skin lesion that is not an ordinary manifestation or complication of the injury.

Original description of angiokeratoma (“Mibelli’s disease” – so named from the latter’s description of it in 1891; see No. 4105).

Hutchinson’s summer prurigo.

On p. 298 is the first description of hydradenitis destruens suppurativa, later named “Pollitzer’s disease” from the latter’s important description of it in J. cutan. gen.-urin. Dis., 1892, 10, 9-24.

Introduction of chrysarobin in dermatology.

First description of prurigo nodularis. In 1909 J. N. Hyde (Diseases of the skin, Philadelphia, p. 174) was responsible for its present name and for the eponym “Hyde’s disease”.

First description of epidermolysis bullosa.

First description of dermatitis herpetiformis (“Duhring’s disease”; see No. 4083).

“Maffucci’s syndrome” – cavernous hemangioma with enchondromas of skeleton, producing deformities.

Excellent pathological study of this condition (“Kaposi’s disease”), which he first described in Virchow’s Handbuch der speziellen Pathologie und Therapie, 1876, 2, 182.

Hereditary angioedema is also known as Quincke’s edema, from the latter’s excellent description of it, but he was preceded by several other writers, including Donati (No. 4011.2) and Milton (No. 4070). It is also called “Bannister’s disease”. English translation in No. 2241.

One of Virchow’s distinguished pupils, von Recklinghausen gave a classic description of neurofibromatosis, adding much to the knowledge of the condition, which later became known as “Recklinghausen’s disease”. The article first appeared as a contribution to the Virchow Festschrift, also published in 1882. See No. 4566.

First description of skin changes and necropsy findings in pseudoxanthoma elasticum. See No. 4096.1 and Trans. St. John’s Hosp. Derm. Soc., 1972, 58, 235-50 (F.M. Pope).

Duhring’s best work in dermatology. He brought together, under the name of “dermatitis herpetiformis” (“Duhring’s disease”) the group of eruptions which morphologically lay between urticaria and the toxic erythemas on the one hand and pemphigus on the other. Duhring wrote the first American textbook on dermatology.

Robinson wrote an excellent textbook on dermatology in 1884, the year in which he published the first description of hydrocystoma (“Robinson’s disease”).

First description of lymphoderma perniciosa, premycotic or leukemic erythrodermia.

Kaposi is credited with the first description of this condition, sometimes called “Kaposi’s disease”, and probably a rare variety of lichen planus.

“Neumann’s disease” – pemphigus vegetans. This was first described by Alibert. English translation (New Sydenham Society), 1897.

“Vidal’s disease” – neurodermatitis.

First description of impetigo circumpilaris infantilis (“Bockhart’s impetigo”).

“Giovanni’s disease”. He described the developmental defect of hair follicles known as pili multigemini.

Although not the first to describe this condition, Kaposi established its status.

Unna’s seborrhoeic eczema.

White, a pupil of Hebra, was an outstanding personality in American dermatology; he held the first chair in that subject in the U.S.A. The eponym “White’s disease” refers to his description of keratosis follicularis in J. cutan. gen.-urin. Dis., 1889, 7, 201-09, a condition described earlier by Lutz and later by Darier.

Folliculitis decalvans of Quinquaud first described. At about the same time, P. A. Robert described it independently in his thesis, Paris, 1889.

Besnier–Boeck–Schaumann disease, Boeck’s sarcoid. Boeck (No. 4128) wrote a classic paper on the subject and later Schaumann’s paper (No. 4149) resulted in a triple eponym. (See No. 4067).

Erythema elevatum diutinum (“Bury’s disease”).

In 1889 Chauffard gave an important description of pseudoxanthoma elasticum. Further reports on his patient were published by Besnier and Doyon, Darier, and Hallopeau and Laffitte, the last in Ann. Derm. Syph. (Paris), 1903, 4, 595.

Dyskeratosis follicularis was so well described by Darier that it is universally known as “Darier’s disease”. J. C. White also described it (see No. 4093) and the first description is accredited to H.C. Lutz (No. 4050).

“Hilliard’s lupus”. Hutchinson made an innovation in terminology when he named the disease after the patient instead of the physician describing it. The Archives, which ran to 11 volumes, were written entirely by Hutchinson. See also Polyclinic, 1900, 2, 104-09, for a fuller description of this patient.

“Jacquet’s disease”, “Jacquet’s dermatitis”, papulo-lenticular erythema of the napkin area.