2018 REICH, David (1973 – )
Who we are and how we got here: Ancient DNA and the new science of the human past.
GMN 10145 · https://historyofmedicine.com/id/12334
2018 LEWIS, Daniel
Belonging on an island: Birds, extinction, and evolution in Hawai'i.
GMN 10425 · https://historyofmedicine.com/id/12618
2018 PÄÄBO, Svante (1955 – ); SLON, Viviane; MAFESSONI, Fabrizio; VERNOT, Benjamin; ET AL
The genome of the offspring of a Neanderthal mother and a Denisovan father.
Paleogenomic study of a single bone fragment from a female hominin found in the Denisova Cave in the Altai mountains of Russia provided "direct evidence for genetic mixture between Neanderthals and Denisovans on at le…
GMN 14099 · https://historyofmedicine.com/id/16410
2018 SZYMANOWSKI, Julius Alfons Nikolai (1829 – 1868); KIMSEY, Isaac J.; AL-HASHIMI, Hashim M.; ET AL
Dynamic basis for dG•dT misincorporation via tautomerization and ionization.
In 1953 Watson and Crick proposed that rarely formed isomers of DNA bases cause spontaneous mutations to occur during the copying of DNA. Such mutations would be easily accommodated because tautomeric mispairs do not …
GMN 14151 · https://historyofmedicine.com/id/16466
2019 ARMSTRONG, Gregory L.; MACCANNELL, Duncan R.; TAYLOR, Jill; ET AL
Pathogen genomics in public health.
"An important transformation is under way in public health. Next-generation sequencing (also called “high-throughput sequencing”) is reshaping communicable disease surveillance, allowing for earlier detection and more…
GMN 11398 · https://historyofmedicine.com/id/13597
2019 ALMEIDA, Alexandre; MITCHELL, Alex L.; BOLAND, Miguel; ET AL
A new genomic blueprint of the human gut microbiota.
Order of authorship in the original publication: Almeida, Mitchell, Boland.... Abstract: "The composition of the human gut microbiota is linked to health and disease, but knowledge of individual microbial species is n…
GMN 11462 · https://historyofmedicine.com/id/13661
2019 PORTER, James W.
The professional library of James W. Porter on corals and coral reefs.
GMN 11804 · https://historyofmedicine.com/id/14006
2019 LIU, David Ruchien (1973 – ); ANZALONE, Andrew V.; RANDOLPH, Peyton B.; DAVIS, Jessie R.; ET AL
Search-and-replace genome editing without double-stranded breaks or donor DNA.
Order of authorship in the original publication: Anzalone, Randolph, Davis....Liu. Liu and colleagues modified the CRISPR tool to create the "prime editing" or precise genome editing technique. Working with human and …
GMN 11866 · https://historyofmedicine.com/id/14070
2019 BORLIK, Todd Andrew
Literature and nature in the English renaissance: An ecocritical anthology. Edited by Todd Andrew Borlik.
GMN 11999 · https://historyofmedicine.com/id/14207
2020 DOUDNA, Jennifer Anne (1964 – )
The promise and challenge of therapeutic genome editing.
A review of the scope of potential genome editing applications, the strategies from the most basic (2012) to the most recent (i.e. No. 11866), the current status of tissue specific delivery, accuracy, precision and sa…
GMN 11867 · https://historyofmedicine.com/id/14071
2020 HAMPTON, Hannah G.; WATSON, Bridget N. J.; FINERAN, Peter C.
The arms race between bacteria and their phage foes.
Order of authorship in the original publication: Hampton, Watson, Fineran. Summarizes, and documents with 173 references, the extensive research on the multitude of methods that bacteriophages use to disable the CRISP…
GMN 11868 · https://historyofmedicine.com/id/14072
2020 MENDOZA, Senen D.; NIEWEGLOWSKA, Eliza S.; GOVINDARAJAN, Sutharsan; ET AL
A bacteriophage nucleus like compartment shields DNA from CRISPR nucleases.
Order of authorship in the original publication: Mendoza, Nieweglowska, Govindarajan. The authors showed that the large phage that specifically infects a Pseudomonas bacterium segregates its DNA, which the phage CRISP…
GMN 11876 · https://historyofmedicine.com/id/14080
2020 DOUDNA, Jennifer Anne (1964 – ); AL-SHAYEB, Basem; SACHDEVA, Rohan; CHEN, Lin-Xin; ET AL
Clades of huge phages from across Earth's ecosystems.
Order of authorship in the original publication: Al-Shayeb, Sachdeva, Chen.... Doudna. Open access, available from nature.com at this link. This paper was a collaboration of about 50 scientists of diverse regions and …
GMN 11877 · https://historyofmedicine.com/id/14081
2020 IMACHI, Hiroyuki; NOBU, Masaru K.; NAKAHARA, Nozomi; TAKAI, Ken; ET AL
Isolation of an archeon at the prokaryote eukaryote interface.
(Order of authorship in the original publication: Imachi, Nobu, Nakahara...Takai.) The authors report that after 12 years of research they have cultured a microorganism that may be the transitional species between pro…
GMN 12302 · https://historyofmedicine.com/id/14524
2020 XU, Chi; KOHLER, Timothy A.; LENTON, Timothy Michael (1973 – ); SVENNING, Jens-Christian (1970 – ); SCHEFFER, Martin (1958 – )
Future of the human climate niche.
Significance "We show that for thousands of years, humans have concentrated in a surprisingly narrow subset of Earth’s available climates, characterized by mean annual temperatures around ∼13 °C. This distribution lik…
GMN 12602 · https://historyofmedicine.com/id/14842
2020 MORANGE, Michel (1950 – )
The black box of biology: A history of the molecular revolution. Translated by Matthew Cobb.
"The Black Box of Biology shows that what led to the incredible transformation of biology was not a simple accumulation of new results, but the molecularization of a large part of biology. In fact, Morange argues, the…
GMN 12639 · https://historyofmedicine.com/id/14880
2020 SENIOR, Andrew W.; EVANS, Richard; JUMPER, John; ET AL
Improved protein structure prediction using potentials from deep learning.
Order of authorship in the original paper: Senior, Evans, Jumper. ABSTRACT: "Protein structure prediction can be used to determine the three-dimensional shape of a protein from its amino acid sequence. This problem is…
GMN 13106 · https://historyofmedicine.com/id/15359
2020 SUMMERHAYES, Colin P.
Paleoclimatology: From snowball earth to the anthropocene.
GMN 13466 · https://historyofmedicine.com/id/15740
2020 WRAPP, Daniel; WANG, Nianshuang; CORBETT, Kizzmekia Shanta (1986 – ); GRAHAM, Barney S.; ET AL
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Posted online on February 17, 2020. 2019-nCoV was an interim name for the Novel Coronavirus. These studies, which included the 3D structure of the RBD (receptor binding domain) within the S protein, provided informati…
GMN 13483 · https://historyofmedicine.com/id/15757
2020 HOLMES, Edward Charles (1965 – ); ZHANG, Yong-Zhen (Zhang Yongzhen) (1964 – )
Novel 2019 coronavirus genome.
https://virological.org/t/novel-2019-coronavirus-genome/319 "Novel 2019 coronavirus genome "10th January 2020 "This posting is communicated by Edward C. Holmes, University of Sydney on behalf of the consortium led by …
GMN 13485 · https://historyofmedicine.com/id/15759
2020 EVANS, John H. (1965 – )
The human gene editing debate.
"Provides a history of the debate about gene editing, a summary of the ethics, and a proposal for moving forward. Re-conceptualizes the historical discussion about gene editing in the context of today's widespread use…
GMN 13776 · https://historyofmedicine.com/id/16063
2020 PÄÄBO, Svante (1955 – ); ZEBERG, Hugo
The major genetic risk factor for severe COVID-19 is inherited from Neanderthals.
Expanding on previous findings by a genome wide association study of severe COVID-19, specifically with respiratory failure which had found that a gene cluster residing on chromosome 3 had a significant association wi…
GMN 14098 · https://historyofmedicine.com/id/16409
2020 NAKANE, Takanore; KOTECHA, Abhay; SENTE, Andrija; ET AL
Single particle cryo-EM at atomic resolution.
The authors located individual atoms with a protein molecule for the first time using cryo-EM. This was the highest resolution imaging of a single protein molecule achieved to date using cryo-EM. Order of authorship o…
GMN 14185 · https://historyofmedicine.com/id/16501
2021 FRANGOUL, Haydar A.; ALTSHULER, David Matthew (1964 – ); CAPPELLINI, Maria Domenica; ET AL
CRISPR-Cas9 gene editing for sickle cell disease and ß-thalassemia.
First application of CRISPR gene editing in the successful cure of diseases. Order of authorship in the original publication: Frangoul, Altshuler, Cappellini. (Thanks to Juan Weiss for this reference and its interpret…
GMN 13478 · https://historyofmedicine.com/id/15752
2021 EVANS, Richard; JUMPER, John; HASSABIS, Demis (1976 – ); ET AL
Highly accurate protein structure prediction with AlphaFold.
Abstract: "Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function. Through an enormous experimental effort1,2,3,4, the structures of around 100,0…
GMN 14026 · https://historyofmedicine.com/id/16333
2021 LIU, David Ruchien (1973 – ); COLLINS, Francis Sellers (1950 – ); KOBLAN, Luke W.; ERDOS, Michael R.; WILSON, Christopher; ET AL
In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice.
Using the base editor enzyme developed by Liu (GM11865), the authors report that they can “correct the pathogenic HGPS mutation in cultured fibroblasts derived from children with progeria and in a mouse model of HGPS.…
GMN 14218 · https://historyofmedicine.com/id/16535
2022 NURK, Sergei; KOREN, Sergei; RHIE, Arang; MIGA, Karen Elizabeth Hayden; ET AL
The complete sequence of a human genome.
The first sequence of the complete human genome, telomere to telomere, including transcriptional and epigenetic state of the repeat elements, adding 8% novel genome information left unresolved since the 2001 draft seq…
GMN 14022 · https://historyofmedicine.com/id/16329
2022 VIRADI, Mihaly; ANYANGO, Stephen; VELANKAR, Sameer; ET AL
AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models.
Abstract: "The AlphaFold Protein Structure Database (AlphaFold DB, https://alphafold.ebi.ac.uk) is an openly accessible, extensive database of high-accuracy protein-structure predictions. Powered by AlphaFold v2.0 of …
GMN 14027 · https://historyofmedicine.com/id/16334
2022 CARLSON, Colin J. (1996 – ); ALBERY, Gregory F.; MEROW, Cory; ET AL
Climate change increases cross-species viral transmission risk.
1) Using a phylogeographical model of the mammal-virus network, and projections of geographical range shifts, the authors assert that 3,139 mammal species will aggregate in new combinations at high elevations, seeking…
GMN 14049 · https://historyofmedicine.com/id/16359
2022 KORZH, Vladimir P.; GASANOV, Eugene V.
Genetics of atavism.
Abstract: "Atavisms have attracted people’s attention for a long time. First, atavisms excited their imagination and created fertile ground for myths and superstitions. With the development of science, atavisms became…
GMN 14107 · https://historyofmedicine.com/id/16418
2023 NIEH, James C.; DONG, Shihao; LIN, Tao; TAN, Ken
Social signal learning of the waggle dance in honey bees.
The authors showed that the complex waggle dance, previously thought to be an inborn trait, is partly learned by young bees as they observe more experienced bees. Abstract: "Honey bees use a complex form of spatial re…
GMN 14139 · https://historyofmedicine.com/id/16453
12963 PAULING, Linus Carl (1901 – 1994); ZUCKERKANDL, Émile (1922 – 2013)
Chemical paleogenetics: Molecular "restoration studies' of extinct forms of life.
Coinage of the term "paleogenetics" in what may be the first publication on the possibility of reconstructing extinct life forms through molecular biology. "Attention is attracted to the possibility of reconstructing …
GMN 14368 · https://historyofmedicine.com/id/16700
