1886 MAYER, Adolf Eduard Maydolf (1843 – 1942)
Ueber die Mosaikkrankheit des Tabaks.
Mayer was first to describe and name tobacco mosaic disease and to demonstrate its infectious nature, that it could be transferred between plants, similar to bacterial infections. Translation in Phytopathological Clas…
GMN 2503.1 · https://historyofmedicine.com/id/3207
1892 IVANOVSKI, Dmitri Iosifovich (Ivanowski; Iwanowski) (1864 – 1920)
Ueber die Mosaikkrankheit der Tabakspflanze.
The Russian botanist Ivanovski demonstrated that the agent responsible for tobacco mosaic disease could pass through the finest filter then available. This was the starting point of research into the etiology of virus…
GMN 2506.2 · https://historyofmedicine.com/id/3229
1898 BEIJERINCK, Martinus Willem (1851 – 1931)
Ueber ein Contagium vivum fluidum als Ursache der Fleckenkrankheit der Tabaksblätter.
Beijerinck confirmed the findings of Ivanovski. He showed that the tobacco mosaic virus would diffuse through agar. "Like Ivanovsky before him and Adolf Mayer, predecessor at Wageningen, Beijerinck could not culture t…
GMN 2512 · https://historyofmedicine.com/id/3254
1935 STANLEY, Wendell Meredith (1904 – 1971)
Isolation of a crystalline protein possessing the properties of tobacco-mosaic virus.
Stanley first crystallized a virus— tobacco mosaic virus. The following year Bawden, Pirie, Bernal and Fankuchen (No. 12005) showed that tobacco mosaic virus molecules are asnisometric and consist of ribonucleoprotein…
GMN 2524.5 · https://historyofmedicine.com/id/3353
1936 BERNAL, John Desmond (1901 – 1971); BAWDEN, Sir Frederick Charles (1908 – 1972); PIRIE, Norman Wingate (1907 – 1997); FANKUCHEN, Isidor (1904 – 1964); ET AL
Liquid crystalline substances from virus infected plants.
Order of authorship in the original publication: Bawden, Pirie, Bernal, Fankuchen. The authors isolated and crystallized tobacco mosaic virus, finding for the first time that a virus contained nucleic acids, when othe…
GMN 12005 · https://historyofmedicine.com/id/14213
1955 FRAENKEL-CONRAT, Heinz Ludwig (1910 – 1999); WILLIAMS, Robley Cook (1908 – 1995)
Reconstitution of active tobacco mosaic virus from its inactive protein and nucleic acid components.
First reconstitution of a virus.
GMN 2527 · https://historyofmedicine.com/id/3465
1955 FRANKLIN, Rosalind Elsie (1920 – 1958)
Structure of tobacco mosaic virus.
The first discovery of the geometry of a protein structure. Franklin, whose X-ray photographs of DNA were crucial to Watson and Crick's discovery of the molecule's double helix structure in 1953, began researching the…
GMN 14001 · https://historyofmedicine.com/id/16306
1956 GIERER, Alfred (1929 – ); SCHRAMM, Gerhard (1910 – 1989)
Infectivity of ribonucleic acid from tobacco mosaic virus.
Proof that nucleic acid produces infectivity. See also Z. Naturf., 1956, 11b, 138-42.
GMN 2578.17 · https://historyofmedicine.com/id/4154
1999 HARRISON, Bryan Desmond (1931 – ); WILSON, T. M. A.
Tobacco mosaic virus: Pioneering research for a century. A theme issue edited by B. D. Harrison and T. M. A. Wilson.
GMN 11071 · https://historyofmedicine.com/id/13267
2001 CREAGER, Angela N. H. (1963 – )
The life of a virus: Tobacco mosaic virus as an experimental model, 1930-1965.
Tobacco mosaic virus was the first virus isolated and crystallized.
GMN 9337 · https://historyofmedicine.com/id/11519
