1978 ALTER, Harvey James (1935 – ); PURCELL, Robert Harry (1935 – ); HOLLAND, Paul; ET AL

Transmissible agent in non-A, non-B hepatitis.

The first paper recording the discovery of what was, eleven years later in 1989, named the hepatitis C virus (see No. 12653). Harvey Alter and colleagues inoculated the serum/plasma of 4 patients with non-A/non-B hepa…

GMN 13540 · https://historyofmedicine.com/id/15817

1989 HOUGHTON, Michael; CHOO, Qui-Lim; KUO, George Ching-Hung; BRADLEY, Daniel W. (1941 – ); OVERBY, Lacy Rasco (1920 – 1994); WEINER, A. J.

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome.

In this paper Houghton and colleagues named “hepatitis C” for the first time. They cloned and isolated the viral RNA genome and demonstrated that a patient who had high antibodies to a ‘native/wild strain’, reacted sp…

GMN 12653 · https://historyofmedicine.com/id/14896

1997 RICE, Charles Moen (1952 – ); KOLYKHALOV, Alexander M; AGAPOV, Eugene V.; ET AL

Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA.

Rice and colleagues constructed a viral RNA genome with the 3’ region and a consensus region to exclude potential inactivating mutations, which was then injected into the liver of chimps. That RNA, specifically encode…

GMN 13541 · https://historyofmedicine.com/id/15818