1910 HERRICK, James Bryan (1861 – 1954)
Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia.
Identification of the sickle-cell type of anemia. Abstract "This case is reported because of the unusual blood findings, no duplicate of which I have ever seen described. Whether the blood picture represents merely a …
GMN 3133 · https://historyofmedicine.com/id/3939
1922 MASON, Verne Rheem (1889 – 1965)
Sickle-cell anemia.
Mason gave sickle-cell anemia its present name.
GMN 3136.1 · https://historyofmedicine.com/id/3943
1949 PAULING, Linus Carl (1901 – 1994); ITANO, Harvey Akio (1920 – 2010); SINGER, Seymour Jonathan (1924 – 2017); WELLS, Ibert C. (1921 – 2011)
Sickle cell anemia, a molecular disease.
First recognition, by Pauling and colleagues, of a structural hemoglobin variant, and the beginning of the molecular approach to disease.
GMN 3154.1 · https://historyofmedicine.com/id/4015
1949 NEEL, James Van Gundia (1915 – 2000)
The inheritance of sickle cell anemia.
Genetic evidence that sickle-cell disease is inherited in a simple Mendelian manner.
GMN 3154.2 · https://historyofmedicine.com/id/4053
1954 ALLISON, Anthony Clifford (1925 – 2014)
Protection afforded by sickle-cell trait against subtertian malarial infection.
Allison was the first to connect a hereditary disease (sickle cell disease) to an infectious disease (malaria). He proved that heterozygous and homozygous individuals to the sickle cell trait or disease respectively s…
GMN 11887 · https://historyofmedicine.com/id/14091
1957 INGRAM, Vernon Martin (1924 – 2006)
Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin.
Sickle-cell hemoglobin differs from normal hemoglobin by a single amino acid (valine for glutamic acid).
GMN 3155.1 · https://historyofmedicine.com/id/4055
1966 LEHMANN, Hermann (1910 – 1985); HUNTSMAN, Richard George (1927 – 2015)
Man’s haemoglobins: including the haemoglobinopathies and their investigation.
Explains the current distribution of sickling throughout the world.
GMN 3155.4 · https://historyofmedicine.com/id/4091
1968 LEHMANN, Hermann (1910 – 1985); PERUTZ, Max Ferdinand (1914 – 2002)
Molecular pathology of human haemoglobin.
Perutz opened up "the field of 'molecular pathology,' relating a structural abnormality to a disease" (Aaron Klug, "Max Perutz 1914-2002," Science 295 ([2002] 2383). Specifically Perutz showed that hemoglobin molecule…
GMN 6916 · https://historyofmedicine.com/id/9081
1985 MULLIS, Kary Banks (1944 – 2019); ET AL
Enzymatic amplication of B-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.
Polymerase chain reaction first published. With Randall K. Saiki, Stephen Scharf, Fred Faloona et al. Order of authorship in the original paper was Saiki, Scharf, Faloona, Mullis.... In 1993 the Nobel Prize in Chemist…
GMN 10785 · https://historyofmedicine.com/id/12981
2001 WAILOO, Keith A. (1962 – )
Dying in the City of the Blues: Sickle cell anemia and the politics of race and health.
"Set in Memphis, home of one of the nation's first sickle cell clinics, Dying in the City of the Blues reveals how the recognition, treatment, social understanding, and symbolism of the disease evolved in the twentiet…
GMN 10335 · https://historyofmedicine.com/id/12527
2021 FRANGOUL, Haydar A.; ALTSHULER, David Matthew (1964 – ); CAPPELLINI, Maria Domenica; ET AL
CRISPR-Cas9 gene editing for sickle cell disease and ß-thalassemia.
First application of CRISPR gene editing in the successful cure of diseases. Order of authorship in the original publication: Frangoul, Altshuler, Cappellini. (Thanks to Juan Weiss for this reference and its interpret…
GMN 13478 · https://historyofmedicine.com/id/15752
