1822 –1823 MARCET, Alexander John Gaspard (1770 – 1822)

Account of a singular variety of urine, which turned black soon after being discharged; with some particulars respecting its chemical properties.

Alkaptonuria described.

GMN 3912 · https://historyofmedicine.com/id/5014

1859 BOEDEKER, Carl Wilhelm (1815 – 1895)

Lieber das Alcapton; ein neuer Beitrag zur Frage: welche Stoffe des Harns können Kupferreduction bewirken?

Excretion of homogentisic acid (in alkaptonuria) first described.

GMN 3913 · https://historyofmedicine.com/id/5024

1909 GARROD, Sir Archibald Edward (1857 – 1936)

Inborn errors of metabolism.

Garrod established chemical individuality as a paradigm of Mendelian variation. His study, which he began around the turn of the 20th century, coincided with the rediscovery of Mendel's laws of inheritance in 1900. He…

GMN 244.1 · https://historyofmedicine.com/id/5049