1924 CALMETTE, Léon Charles Albert (1863 – 1933); GUÉRIN, Camille (1872 – 1961); WEILL-HALLÉ, Benjamin (1875 – 1958); ET AL
Essai d’immunisation contre l’infection tuberculeuse.
B.C.G. (Bacille Calmette–Guérin) vaccine was first produced in 1906 and subcultured for 13 years. It was first used as a prophylactic against tuberculosis in children in 1921. It remains in use. See also No. 2346.
GMN 2343 · https://historyofmedicine.com/id/3094
1924 DICK, George Frederick (1881 – 1967); DICK, Gladys Rowena Henry (1881 – 1963)
A skin test for susceptibility to scarlet fever.
The “Dick test” for the determination of individual susceptibility to scarlet fever.
GMN 5082 · https://historyofmedicine.com/id/5946
1924 DICK, George Frederick (1881 – 1967); DICK, Gladys Rowena Henry (1881 – 1963)
The etiology of scarlet fever.
Proof that streptococcus is the cause of scarlet fever.
GMN 5082.1 · https://historyofmedicine.com/id/5949
1925 CHURCHMAN, John Woolman (1877 – 1937)
Intravenous use of dyes.
Churchman demonstrated the selective bactericidal action of gentian violet against staphylococci. See also J. exp. Med., 1912, 16, 221-47; J. Urol., 1924, 11, 1-18.
GMN 1911 · https://historyofmedicine.com/id/2673
1926 MURRAY, Everitt George Dunne (1890 – 1964); ET AL
A disease of rabbits characterised by a large mononuclear leucocytosis, caused by a hitherto undescribed bacillus acterium monocytogenes (n. sp.).
Isolation of Listeria monocytogenes. With R. A. Webb and M. B. R. Swann.
GMN 2522.1 · https://historyofmedicine.com/id/3312
1926 PLACE, Edwin Hemphill (1880 – ); ET AL
Erythema arthriticum epidemicum; preliminary report.
“Haverhill fever” first reported. The writers isolated an organism, later found to be identical with Streptothrix muris ratti and Streptobacillus moniliformis. With L. E. Sutton and O. Willner.
GMN 5328 · https://historyofmedicine.com/id/6636
1926 SEIBERT, Florence Barbara (1897 – 1991)
Isolation of a crystalline protein with tuberculin activity.
Siebert identified the active agent in tuberculin as a protein.
GMN 12386 · https://historyofmedicine.com/id/14613
1927 CALMETTE, Léon Charles Albert (1863 – 1933); GUÉRIN, Camille (1872 – 1961); BOQUET, Alfred (1879 – 1947); NÈGRE, Léopold (1879 – 1961)
Sur la vaccination préventive des enfants nouveau-nés contre la tuberculose par le B.C.G.
GMN 2346 · https://historyofmedicine.com/id/3105
1927 CALMETTE, Léon Charles Albert (1863 – 1933); GUÉRIN, Camille (1872 – 1961); BOQUET, Alfred (1879 – 1947); NÈGRE, Léopold (1879 – 1961)
La vaccination préventive contre la tuberculose par le "BGG". Par Albert Calmette avec la collaboration de C. Guérin, A. Boquet et L. Nègre.
A 250-page monograph, with bibliographical references, on the development of the BCG vaccine from M. bovis, from 1909 to 1927 by the scientists involved. (Thanks to Ron Cox for this reference.)
GMN 11994 · https://historyofmedicine.com/id/14202
1928 –1929 THOMSON, David (1884 – 1969); THOMSON, Robert (1888 – )
The pathogenic streptococci. An historical survey of their role in human and animal disease.
Documents over 1,600 studies.
GMN 2523 · https://historyofmedicine.com/id/3321
1931 ANDERSON, James Stirling (1891 – 1976); ET AL
On the existence of two forms of diphtheria bacillus B. diphtheria gravis and B. diphtheriae mitis.
J. S. Anderson, F. C. Happold, J. W. McLeod, and J. G. Thomson were the first to distinguish the gravis, mitis, and intermediate types of C. diphtheriae.
GMN 5072 · https://historyofmedicine.com/id/5914
1932 CROHN, Burrill Bernard (1884 – 1983); ET AL
Regional ileitis. A pathologic and clinical entity.
“Crohn’s disease” – regional ileitis. With L. Ginzburg and G. D. Oppenheimer. "Some of Crohn's initial research into the causes of the Crohn's disease was centered around his personal conviction that it was caused by …
GMN 3551 · https://historyofmedicine.com/id/4062
1932 THOMSON, David (1884 – 1969); THOMSON, Robert (1888 – )
The common cold, with special reference to the part played by streptococci, pneumococci, and other organisms.
Annals of the Pickett-Thomson Research Lab., Vol. 8.
GMN 3204 · https://historyofmedicine.com/id/4321
1933 LANCEFIELD, Rebecca Craighill (1895 – 1981)
A serological differentiation of human and other groups of hemolytic streptococci.
Lancefield determined the principal pathogenic strains of hemolytic streptococci and subdivided them into types. All important strains pathogenic to humans fall into Lancefield’s Group A.
GMN 2524.2 · https://historyofmedicine.com/id/3337
1934 GRIFFITH, Frederick (1879 – 1941)
The serological classification of Streptococcus pyogenes.
Griffith’s classification of streptococci. Digital facsimile from PubMedCentral at this link.
GMN 2524.3 · https://historyofmedicine.com/id/3346
1934 SEIBERT, Florence Barbara (1897 – 1991)
The isolation and properties of the purified protein derivative of tuberculin
Purification of tuberculin (PPD). By the 1940s Seibert's PPD was the international standard for tuberculin tests.
GMN 12387 · https://historyofmedicine.com/id/14614
1935 KLIENEBERGER-NOBEL, Emmy (1892 – 1985)
The natural occurrence of pleuropneumonia-like organisms in apparent symbiosis with Streptobacillus moniliformis and other bacteria.
Klieneberger isolated typical strains of pleuropneumonia-like organisms from Strep, moniliformis.
GMN 2524.4 · https://historyofmedicine.com/id/3350
1937 LEMIERRE, André (1875 – 1956); ET AL
Sur une nouvelle fièvre par morsure de rat.
A. Lemierre, J. Reilly, A. Laporte, and M. Morin isolated Streptobacillus moniliformis from a case of rat-bite fever.
GMN 5329 · https://historyofmedicine.com/id/6643
1939 STERNE, Max (1905 – 1997)
The use of anthrax vaccines prepared from avirulent (uncapsulatec) variants of Bacillus anthracis.
Nonencapsulated spore vaccine.
GMN 5172.1 · https://historyofmedicine.com/id/6264
1945 FELDMAN, William Hugh (1892 – 1974); HINSHAW, Horton Corwin (1902 – 2001)
Streptomycin in treatment of clinical tuberculosis: a preliminary report.
GMN 2350 · https://historyofmedicine.com/id/3125
1948 MACCALLUM, Sir Peter (1885 – 1974); ET AL
A new mycobacterial infection in man.
Myco. ulcerans first described. With J. C. Tolhurst, G. Buckle, and H. A. Sissons.
GMN 2526 · https://historyofmedicine.com/id/3453
1958 EISEMAN, Ben (1917 – 2012); BASCOM, George S. (1927 – 1993); SILEN, W.; ET AL
Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis.
Order of authorship in the original publication: Eiseman, Silen, Bascom.... Report of the first "fecal transplant / fecal therapy," also known as "faecal microbiota transplanation," for recurrent / resistant C. diffic…
GMN 11458 · https://historyofmedicine.com/id/13657
1995 SØRENSON, Anne L.; NAGAI, Sadamu; HOUEN, Gunnar; ANDERSEN, Peter Lawaetz; ET AL
Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis.
Andersen and colleagues found that a protein fraction obtained from M. tuberculosis was immunologically active in mice, suggesting that it was one of the proteins recognized by T cells. In this paper the authors ident…
GMN 11997 · https://historyofmedicine.com/id/14205
1996 MAHAIRAS, Gregory G.; SABO, Peter J.; HICKEY, Mark J.; ET AL
Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis.
Order of authorship in the original publication: Mahairas, Sabo, Hickey.... From the Abstract: "The live attenuated bacillus Calmette-Guérin (BCG) vaccine for the prevention of disease associated with Mycobacterium tu…
GMN 11995 · https://historyofmedicine.com/id/14203
1998 COLE, S. T.; ET AL
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Abstract: "Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tubercu…
GMN 11998 · https://historyofmedicine.com/id/14206
2005 FREDRICS, David N.; FIEDLER, Tina N.; MARRAZZO, Jeanne M.
Molecular identification of bacteria associated with bacterial vaginosis.
Order of authorship in the original publication: Fredricks, Fiedler, Marrazzo. Using molecular methods, the authors confirmed that absence or greatly reduced number of Lactobacilli was associated with vaginosis. They …
GMN 11396 · https://historyofmedicine.com/id/13595
2007 CORR, Sinéad Cristin; LI, Yin; REIDEL, Christian U.; HILL, Colin; ET AL
Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118.
Order of authorship in the original publication: Corr, Li, Reidel...Hill. The authors discovered that Lactobacilli produce a bacteriocin, a peptidic toxin that inhibits the growth of similar or closely related bacteri…
GMN 11478 · https://historyofmedicine.com/id/13677
2013 NOOD, Els van; VRIEZE, Anne; NIEUWDORP, Max; ET AL
Duodenal infusion of donor feces for recurrent Clostridium difficile.
Order of authorship in the original publication: Nood, Vrieze, Nieuwdorp....This research provided convincing evidence that fecal donation (faecal microbiota transplantation) is more effective therapy for virulent C. …
GMN 11459 · https://historyofmedicine.com/id/13658
2018 PIEWNGAM, Pipat; ZHENG, Yue; NGUYEN, Thuan H.; ET AL
Pathogen elimination by probiotic Bacillus via signaling interference.
Order of authorship in the original publication: Piewngam, Zheng, Nguygen....The authors discovered a mechanism by which probiotics help maintain a healthy microbiome. They showed that Bacillus subtilis can produce a …
GMN 11480 · https://historyofmedicine.com/id/13679
2026 CALMETTE, Léon Charles Albert (1863 – 1933); GUÉRIN, Camille (1872 – 1961); SCHWARTZ, David Alan (1953 – ); MIGLIORINI, Lou
Discovery of a handwritten laboratory notebook by Albert Calmette and Camille Guérin describing experimental studies and development of the BCG vaccine for tuberculosis
"Abstract: Background: The Bacille Calmette–Guérin (BCG) vaccine against tuberculosis is the most widespread vaccine in the world. Discovered by French investigators Albert Calmette and Camille Guérin at the Pasteur I…
GMN 14354 · https://historyofmedicine.com/id/16684
