1882 KOCH, Robert Heinrich Hermann (1843 – 1910)
Die Aetiologie der Tuberkulose.
Discovery of the tubercle bacillus announced March 24, 1882. This paper also contains a statement of “Koch’s postulates”. See also Nos. 2536 and 5167. Koch published a fuller account as "Die Aetiologie der Tuberkulose…
GMN 2331 · https://historyofmedicine.com/id/3057
1898 SMITH, Theobald (1859 – 1934)
A comparative study of bovine tubercle bacilli and of human bacilli from sputum.
First clear differentiation between the bovine and human types of tubercle bacillus.
GMN 2335 · https://historyofmedicine.com/id/3074
1908 MENDEL, Felix (1862 – 1925)
Die von Pirquet'sche Hautreaktion und die intravenöse Tuberkulinbehandlung.
First publication on the The Mantoux test or Mendel–Mantoux test (also known as the Mantoux screening test, tuberculin sensitivity test, Pirquet test, or PPD test for purified protein derivative) is a tool for screeni…
GMN 12385 · https://historyofmedicine.com/id/14611
1912 KOCH, Robert Heinrich Hermann (1843 – 1910); GAFFKY, Georg Theodor August (1850 – 1918); SCHWALBE, Julius (1866 – 1930); PFUHL, Ernst (1876 – 1940)
Gesammelte Werke von Robert Koch. Unter Mitwirkung von G. Gaffky and E. Pfuhl. Herausgegeben von J. Schwalbe. 2 vols. [in 3).
For his work on tuberculosis Koch received the Nobel Prize in 1905. Digital facsimile from the Internet Archive at this link. See T.D. Brock, Robert Koch: A life in medicine and bacteriology, Madison, WS: Science-Tech…
GMN 86 · https://historyofmedicine.com/id/1437
1926 SEIBERT, Florence Barbara (1897 – 1991)
Isolation of a crystalline protein with tuberculin activity.
Siebert identified the active agent in tuberculin as a protein.
GMN 12386 · https://historyofmedicine.com/id/14613
1934 SEIBERT, Florence Barbara (1897 – 1991)
The isolation and properties of the purified protein derivative of tuberculin
Purification of tuberculin (PPD). By the 1940s Seibert's PPD was the international standard for tuberculin tests.
GMN 12387 · https://historyofmedicine.com/id/14614
1995 SØRENSON, Anne L.; NAGAI, Sadamu; HOUEN, Gunnar; ANDERSEN, Peter Lawaetz; ET AL
Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis.
Andersen and colleagues found that a protein fraction obtained from M. tuberculosis was immunologically active in mice, suggesting that it was one of the proteins recognized by T cells. In this paper the authors ident…
GMN 11997 · https://historyofmedicine.com/id/14205
1996 MAHAIRAS, Gregory G.; SABO, Peter J.; HICKEY, Mark J.; ET AL
Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis.
Order of authorship in the original publication: Mahairas, Sabo, Hickey.... From the Abstract: "The live attenuated bacillus Calmette-Guérin (BCG) vaccine for the prevention of disease associated with Mycobacterium tu…
GMN 11995 · https://historyofmedicine.com/id/14203
1998 COLE, S. T.; ET AL
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Abstract: "Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tubercu…
GMN 11998 · https://historyofmedicine.com/id/14206
2026 CALMETTE, Léon Charles Albert (1863 – 1933); GUÉRIN, Camille (1872 – 1961); SCHWARTZ, David Alan (1953 – ); MIGLIORINI, Lou
Discovery of a handwritten laboratory notebook by Albert Calmette and Camille Guérin describing experimental studies and development of the BCG vaccine for tuberculosis
"Abstract: Background: The Bacille Calmette–Guérin (BCG) vaccine against tuberculosis is the most widespread vaccine in the world. Discovered by French investigators Albert Calmette and Camille Guérin at the Pasteur I…
GMN 14354 · https://historyofmedicine.com/id/16684
