1908 GELMO, Paul (1879 – 1961)

Ueber Sulfamide der p-Amidobenzolsulfonsäure.

Para-aminobenzenesulfonamide (sulphanilamide) first prepared.

GMN 1948 · https://historyofmedicine.com/id/2822

1930 RUIZ, Celestino L. (1904 – ); ET AL

Contribución al estudio sobre la composición quimica de la insulina. Estudio de algunos cuerpos sintéticos solfurados con acción hypoglucemiante.

Discovery of the hypoglycemic effect of certain sulphonamide derivatives. With L. L. Silva and L. Libenson.

GMN 3973 · https://historyofmedicine.com/id/5284

1935 DOMAGK, Gerhard Johannes Paul (1895 – 1964)

Ein Beitrag zur Chemotherapie der bakteriellen Infektionen.

Introduction of Prontosil, the first drug containing sulfanilamide. In 1939 Domagk was awarded the Nobel Prize in Physiology or Medicine "for the discovery of the antibacterial effects of prontosil."

GMN 1949 · https://historyofmedicine.com/id/2824

1935 BOVET, Daniel (1907 – 1992); TRÉFOUËL, Jacques (1897 – 1977); TRÉFOUËL, Thérèse (1892 – 1978); NITTI, Federico (1903 – 1947)

Activité du p-aminophénylsulfamide sur les infections streptococciques expérimentales de la souris et du lapin.

The Tréfouëls and colleagues assumed that the sulfonamide group was responsible for the results obtained with Domagk’s Prontosil. Their work led them to introduce sulfanilamide.

GMN 1950 · https://historyofmedicine.com/id/2826

1936 COLEBROOK, Leonard (1883 – 1967); KENNY, Méave

Treatment of human puerperal infections, and of experimental infections in mice, with prontosil.

Chemotherapeutic treatment of puerperal sepsis.

GMN 6281 · https://historyofmedicine.com/id/8005

1937 LEVADITI, Constantin (1874 – 1953); VAISMAN, A

La toxi-infection gonococcique expérimentale et son traitement chimiothérapique.

Levaditi and Vaisman showed that sulfanilamide protected mice against gonococcal infection.

GMN 5213.1 · https://historyofmedicine.com/id/7817

1937 DEES, John Essary (1910 – 1993); COLSTON, John Archibald Campbell (1886 – 1971)

The use of sulfanilamide in gonococcic infections. Preliminary report.

GMN 5214.1 · https://historyofmedicine.com/id/7818

1938 WHITBY, Sir Lionel Ernest Howard (1895 – 1956)

Chemotherapy of pneumococcal and other infections with 2-(p-aminobenzenesulphonamido) pyridine.

Experimental proof of the efficacy of sulfapyridine (M & B 693) in pneumococcal pneumonia.

GMN 1951 · https://historyofmedicine.com/id/2827

1938 GAISFORD, Wilfrid Fletcher (1902 – 1988); EVANS, Gladys Mary (1897 – 1973)

Treatment of pneumonia with 2-(p-aminobenzenesulphonamido) pyridine.

Clinical proof of the value of sulphapyridine. M & B 693 (sulphapyridine) treatment of pneumonia. This followed the experimental work of L. E. H. Whitby (see No. 1951).

GMN 1952 · https://historyofmedicine.com/id/2829

1940 GSELL, Otto (1902 – 1990)

Chemotherapie akuter Infektionskrankheiten durch Ciba 3714 (Sulfanilamidothiazol).

First important clinical trial of sulfathiazole.

GMN 1953 · https://historyofmedicine.com/id/2831

1940 MARSHALL, Eli Kennerly Jr. (1889 – 1966); ET AL

Sulfanilylguanidine: a chemotherapeutic agent for intestinal infections.

Sulphaguanidine was introduced by E. K. Marshall, A. C. Bratton, H. J. White, and J. T. Litchfield.

GMN 1954 · https://historyofmedicine.com/id/2833

1940 ROBLIN, Richard Owen Jr. (1907 – 1985); ET AL

Chemotherapy, II. Some sulfanilamido heterocycles.

Synthesis of sulphamerazine, by R. O. Roblin, J. H. Williams, P. S. Winnek, and J. P. English.

GMN 1955 · https://historyofmedicine.com/id/2835

1940 WOODS, Donald Devereux (1912 – 1964)

The relation of p-amniobenzoic acid to the mechanism of the action of sulphanilamide.

Isolation of p-aminobenzoic acid, a structural analog of sulfanilamide.

GMN 1955.1 · https://historyofmedicine.com/id/2837

1941 FINLAND, Maxwell (1902 – 1987); ET AL

Sulfadiazine. Therapeutic evaluation and toxic effects on four hundred and forty-six patients.

Introduction of sulphadiazine. With E. Strauss and O. L. Peterson.

GMN 1956 · https://historyofmedicine.com/id/2839

1941 POTH, Edgar Jacob (1899 – ); KNOTTS, Frank Louis (1912 – 1989)

Succinyl sulfathiazole, a new bacteriostatic agent locally active in the gastrointestinal tract.

Introduction of sulfasuxidine.

GMN 1957 · https://historyofmedicine.com/id/2842

1942 MACARTNEY, Donald William; ET AL

Sulphamethazine: Clinical trial of a new sulphonamide.

Sulfadimidine (also spelled Sulphadimidine) with G. S. Smith, R. W. Luxton, W. A. Ramsay, and J. Goldman. [Also designated as Vol. 239 by publishers of The Lancet.]

GMN 1958 · https://historyofmedicine.com/id/2844

1942 RICH, Arnold Rice (1893 – 1968)

The rôle of hypersensitivity in periarteritis nodosa; as indicated by seven cases developing during serum sickness and sulfonamide therapy.

Rich considered hypersensitivity to be an important factor in the aetiology of periarteritis nodosa.

GMN 2924 · https://historyofmedicine.com/id/4922

2007 LESCH, John E. (1945 – )

The first miracle drugs: How the sulfa drugs transformed medicine.

"In the decade from 1935-1945, while the Second World War raged in Europe, a new class of medicines capable of controlling bacterial infections launched a therapeutic revolution that continues today. The new medicines…

GMN 9230 · https://historyofmedicine.com/id/11412