1975 KÖHLER, Georges Jean Franz (1946 – 1995); MILSTEIN, César (1927 – 2002)
Continuous cultures of fused cells secreting antibody of predefined specificity.
Hybridomas. In 1984 Köhler and Milstein shared the Nobel Prize in Physiology or Medicine with Niels K. Jerne, "for theories concerning the specificity in development and control of the immune system and the discovery …
GMN 2578.43 · https://historyofmedicine.com/id/4314
1989 CLARK, Richard P.
Botulinum toxin: a treatment for facial asymmetry caused by facial nerve paralysis.
First documentation of a cosmetic use for botulinum toxin (Botox). This was one of the early documented applications of a biological medical product.
GMN 11378 · https://historyofmedicine.com/id/13577
2013 SCHWERIN, Alexander von; STOFF, Heiko; WAHRIG, Bettina
Biologics. A history of agents made from living organisms in the twentieth century. Edited by Alexander von Schwerin, Heiko Stoff and Bettina Wahrig.
GMN 11915 · https://historyofmedicine.com/id/14120
2016 MULANGU, Sabue; CORTI, Davide; MISASI, John; ET AL
Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody.
The cited paper was immediately followed in the same issue of Science by: John Misasi, Morgan A. Gilman, Masaru Kanekiyo et al, "Structural and molecular basis for Ebola virus neutralization by protective human antibo…
GMN 11375 · https://historyofmedicine.com/id/13574
2019 MULANGU, Sabue; DODD, Lori E.; DAVEY, Richard T. Jr.; ET AL
A randomized, controlled trial of Ebola virus disease therapeutics.
Order of authorship in the original publication: Mulangu, Dodd, Davey.... One synthetic drug (Remdesivir, an antiviral) and 3 biologicals were used in this trial. The 3 biologicals were: REGN-EB3, a triple monoclonal …
GMN 11374 · https://historyofmedicine.com/id/13573
2020 BAUM, Alina; AJITHDOSS, Dharani K.; KYRATSOUS, Christos A.; ET AL
REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters.
The authors, working at Regeneron, showed that a cocktail of two potent neutralizing monoclonal antibodes reduced virus load in the airways and diminshed viral induced pathological sequelae when given both as a prophy…
GMN 13523 · https://historyofmedicine.com/id/15799
2021 WEINREICH, David. M.; SIVAPALASINGAM, Sumathi; NORTON, Thomas; ET AL
REGN-COV-2, a neutralizing antibody cocktail, in outpatients with Covid-19.
The authors showed that the Regeneron antibody cocktail has a low incidence of side effects and a profound and rapid effect on viral load, with most reduction occurring within 48 hours, even in patents with the highes…
GMN 13524 · https://historyofmedicine.com/id/15800
