1926 –1927 ROEHL, Wilhelm ( – 1929)
Die Wirkung des Plasmochins auf die Vogelmalaria.
Introduction of plasmoquine (pamaquin) in the treatment of malaria.
GMN 5256 · https://historyofmedicine.com/id/7917
1928 SINTON, Brigadier John Alexander (1884 – 1956); BIRD, William
Studies in malaria, with special references to treatment. Part IX. Plasmoquine in the treatment of malaria.
Clinical trials of pamaquin.
GMN 5256.1 · https://historyofmedicine.com/id/7918
1932 KIKUTH, Walter (1896 – 1968)
Zur Weiterentwicklung synthetisch dargestellter Malariamittel. I. Ueber die chemotherapeutische Wirkung des Atebrin.
Introduction of atebrin (mepacrine, quinacrine).
GMN 5257 · https://historyofmedicine.com/id/7919
1945 CURD, Francis Henry Swinton (1909 – 1948); ET AL
Studies on synthetic antimalarial drugs.
F. H. S. Curd, D. G. Davey, and F. L. Rose synthesized proguanil (“paludrine”) and first tested it in avian malaria.
GMN 5260 · https://historyofmedicine.com/id/8545
1945 ADAMS, Alfred Robert Davies (1901 – 1992)
Studies on synthetic antimalarial drugs. XIII. Results of a preliminary investigation of the therapeutic action of 4888 (paludrine) on acute attacks of benign tertian malaria.
First use of proguanil in human malaria. With B. G. Maegraith, J. D. King, R. H. Townsend, T. H. Davey, and R. E. Havard.
GMN 5261 · https://historyofmedicine.com/id/8546
1946 MOST, Harry (1907 – 1994); LONDON, Irving M. (1918 – 2018); LAVIETES, Paul Harold (1907 – 1990)
Chloroquine for treatment of acute attacks of vivax malaria.
Harry Most led the development of chloroquine for use in treating American troops suffering from malaria. At the beginning of the American involvement in the war there were more American casualties from malaria than f…
GMN 5261.1 · https://historyofmedicine.com/id/8547
1948 ALVING, Alf Sven (1902 – 1965)
Pentaquine (Sn-13,276), a therapeutic agent effective in reducing the relapse rate in vivax malaria.
Clinical trials of pentaquine. With B. Craige, R. Jones, C. M. Whorton, T. N. Pullman, and L. Eichelberger.
GMN 5261.2 · https://historyofmedicine.com/id/8548
1950 EDGCOMB, John Harold (1924 – 2007); ET AL
Primaquine, S.N. 13,272, a new curative agent in vivax malaria: a preliminary report.
Introduction of primaquine.
GMN 5262.3 · https://historyofmedicine.com/id/8552
1951 FALCO, E. A.
2:4-Diaminopyrimidines – a new series of antimalarials.
Preparation and laboratory tests of pyrimethamine. With L. G. Goodwin, G. H. Hutchings, I. M. Rollo, and P. B. Russell.
GMN 5262.4 · https://historyofmedicine.com/id/8553
1951 ROLLO, Ian McIntosh (1926 – 2015)
A 2:4-diamino pyrimidine in the treatment of proguanil-resistant laboratory malarial strains.
Pyrimethamine (daraprim).
GMN 5262.5 · https://historyofmedicine.com/id/8554
