1905 THOMAS, Harold Wolferstan (1875 – 1931); BREINL, Anton (1880 – 1944)
Report on trypanosomes, trypanosomiasis, and sleeping sickness, being an experimental investigation into their pathology and treatment.
Thomas and Breinl discovered that arsanilic acid, was more potent in the treatment of laboratory trypanosomiasis than arsenic in inorganic form. As a crystalline powder it was introduced medically as Atoxyl. Thomas an…
GMN 5279 · https://historyofmedicine.com/id/8592
1906 NICOLLE, Maurice (1862 – 1932); MESNIL, Félix (1868 – 1938)
Traitement des trypanosomiases par les “couleurs de benzidine”.
Introduction of trypan-blue in the treatment of trypanosomiasis. Second paper by Mesnil and Nicolle.
GMN 5280 · https://historyofmedicine.com/id/6339
1907 EHRLICH, Paul (1854 – 1915)
Chemotherapeutische Trypanosomen-Studien.
The first account of induced microbial drug resistance. Ehrlich encountered induced drug resistance in microbes while researching arsenical preparations as cures for sleeping sickness and other trypanosome-caused illn…
GMN 5281 · https://historyofmedicine.com/id/6342
1908 PLIMMER, Henry George (1856 – 1918); THOMSON, John D.
Further results of the experimental treatment of trypanosomiasis in rats.
Trial of antimony in the treatment of trypanosomiasis.
GMN 5282 · https://historyofmedicine.com/id/6343
1920 HAENDEL, Ludwig (1869 – 1939); JOETTEN, Karl Wilhelm (1886 – 1958)
Ueber chemotherapeutische Versuche mit “205 Bayer”, einen neuen trypanoziden Mittel von besonderer Wirkung.
Introduction of “Bayer 205” (germanin, suramin, naphuride).
GMN 5286 · https://historyofmedicine.com/id/6361
1921 PEARCE, Louise (1886 – 1959)
Studies on the treatment of human trypanosomiasis with tryparsamide (the sodium salt of N-phenylglycineamide-p-arsonic acid).
Introduction of tryparsamide in the treatment of trypanosomiasis.
GMN 5287 · https://historyofmedicine.com/id/6364
1923 FOURNEAU, Ernest (1872 – 1949)
Chimiothérapie des trypanosomiasis.
Introduction of moranyl (“Foumeau 309”).
GMN 5288 · https://historyofmedicine.com/id/6368
1926 LEVADITI, Constantin (1874 – 1953)
Essai de prophylaxie des trypanosomiases par des dérivés phénylarsiniques administré
First attempt to induce prophylaxis by chemical means in trypanosomiasis. With S. Nicolau and I. Galloway.
GMN 5289 · https://historyofmedicine.com/id/6371
1979 ÕMURA, Satoshi (1935 – ); BURG, Richard W.; MILLER, Brinton M.; BAKER, Edward E.; ET AL
Avermectins, new family of potent anthelmintic agents: Producing organism and fermentation.
The authors, lead by Omura, announced the discovery of Streptomyces avermilitis. They described the structure of avermectin, and reported preliminary observations that this drug is antiparasitic. (Order of authorship …
GMN 12630 · https://historyofmedicine.com/id/14871
1979 CAMPBELL, William Cecil (1930 – ); EGERTON, J. R.; OSTLIND, D. A.; BLAIR, L. S.; ET AL
Avermectins, new family of potent anthelminthic agents, efficacy of the B1a component.
Campbell and colleagues reported unprecedented antiparasitic effects of the agent in vivo, and that the "B1a" component of the molecule was most effective as a single oral dose. (Order of authorship in the original pu…
GMN 12631 · https://historyofmedicine.com/id/14872
1983 CAMPBELL, William Cecil (1930 – ); FISHER, M. H.; STAPLEY, E. O.; ET AL
Ivermectin: A potent new antiparasitic agent.
Abstract "Ivermectin is the 22,23-dihydro derivative of avermectin B1, a macrocyclic lactone produced by an actinomycete, Streptomyces avermitilis. It is active at extremely low dosage against a wide variety of nemato…
GMN 12632 · https://historyofmedicine.com/id/14873
