1953 CHANG, Min Chueh (1908 – 1991); PINCUS, Gregory Goodwin (1903 – 1967)

The effects of progesterone and related compounds on ovulation and early development in the rabbit.

First practical demonstration of an oral contraceptive.

GMN 1931.2 · https://historyofmedicine.com/id/2754

1954 DJERASSI, Carl (1923 – 2015); MIRAMONTES CARDÉNAS, Luis Ernesto (1925 – 2004); ROSENKRANZ, George (1916 – ); SONDHEIMER, Franz (1926 – 1981)

Steroids. LIV.Synthesis of 19-Nov-17α-ethynyltestosterone and 19-Nor-17α-methyltestosterone.

Synthesis of Norethisterone (or norethindrone) (or 19-nor-17α-ethynyltestosterone), the first highly active progestin analog that was effective when taken by mouth. This molecule became part of one of the first succes…

GMN 7085 · https://historyofmedicine.com/id/9252