1922 FLEMING, Sir Alexander (1881 – 1955)

On a remarkable bacteriolytic element found in secretions and tissues.

Lysozyme, an antimicrobial enzyme that is a component of secretions such as tears and saliva. Digital facsimile from royalsocietypublishing.org at this link

GMN 1910.1 · https://historyofmedicine.com/id/2667

1986 YARCHOAN, Robert (1950 – ); WEINHOLD, Kent James; LYERLY, Herbert Kim; ET AL

Administration of 3'-Azido-3'-Deoxythmymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex.

Order of authorship in the original publication: Yarchoan, Weinhold, Lyerly. The first antiviral AIDS drug, later named "Retrovir"/ Zidovudine/AZT. (Thanks to Juan Weiss for this reference and its interpretation.)

GMN 11106 · https://historyofmedicine.com/id/13302

2019 MULANGU, Sabue; DODD, Lori E.; DAVEY, Richard T. Jr.; ET AL

A randomized, controlled trial of Ebola virus disease therapeutics.

Order of authorship in the original publication: Mulangu, Dodd, Davey.... One synthetic drug (Remdesivir, an antiviral) and 3 biologicals were used in this trial. The 3 biologicals were: REGN-EB3, a triple monoclonal …

GMN 11374 · https://historyofmedicine.com/id/13573

2021 OWEN, Dafydd R.; ALLERTON, Charlotte M. N.; ANDERSON, Annaliesa S.

An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.

The authors showed how a coronavirus specific protease inhibitor designed in the lab, that could be administered by mouth to humans, achieved excellent plasma concentrations and antiviral potency. This drug, marketed …

GMN 14023 · https://historyofmedicine.com/id/16330