1759 HILLARY, William (1697 – 1763)
Observations on the changes of the air and the concomitant epidemical diseases, in the Island of Barbados.
Hillary included good accounts of lead colic and infective hepatitis, and probably the first description of sprue (celiac disease).
GMN 1770 · https://historyofmedicine.com/id/3314
1874 HAYEM, Georges (1841 – 1933)
Contribution à l’étude de l’hépatite interstitielle chronique avec hypertrophie (sclérose ou cirrhose hypertrophique du foie).
Classic description of chronic interstitial hepatitis.
GMN 3623 · https://historyofmedicine.com/id/4568
1885 LÜRMAN, August
Eine Icterusepidemie.
Dr. Lürman, a general practitioner in Bremen, was first to report homologous serum hepatitis. English translation in Human viral hepatitis, by A. J. Zuckerman, 2nd ed., New York, 1972, pp. 4-10.
GMN 3628 · https://historyofmedicine.com/id/4581
1891 STADELMANN, Ernst (1853 – 1941)
Der Icterus und seine verschiedenen Formen.
GMN 3633 · https://historyofmedicine.com/id/4621
1912 ROGERS, Sir Leonard (1868 – 1962)
The rapid cure of amoebic dysentery and hepatitis by hypodermic injections of soluble salts of emetine.
Following up the work of Vedder, Rogers showed that the soluble salts of emetine could be safely injected subcutaneously. The general use of emetine, introduced by Rogers, diminished the incidence of liver abscess – a…
GMN 5190 · https://historyofmedicine.com/id/7047
1931 DAUBNEY, Robert (1891 – ); HUDSON, John Richard
Enzootic hepatitis or Rift Valley fever. An undescribed virus disease of sheep, cattle and man from East Africa.
First description.
GMN 5541 · https://historyofmedicine.com/id/6730
1942 VOEGT, H
Zur Aetiologie der Hepatitis epidemica.
Transmission of infective hepatitis agent.
GMN 3664.1 · https://historyofmedicine.com/id/4813
1944 MACCALLUM, Frederick Ogden; BRADLEY, W. H.
Transmission of infective hepatitis to human volunteers.
MacCallum and Bradley finally proved the nature of both serum and infective hepatitis.
GMN 3664.2 · https://historyofmedicine.com/id/4815
1957 ISAACS, Alick (1921 – 1967); LINDENMANN, Jean (1924 – 2015)
Virus interference. I. The interferon.
Discovery of interferon type I, a protein that interferes with viral replication. "While working together at the NIMR, Lindenmann and Isaacs noticed that if they killed viruses using heat and applied the dead viruses …
GMN 2578.22 · https://historyofmedicine.com/id/4236
1965 BLUMBERG, Baruch Samuel (1925 – 2011); ALTER, Harvey James (1935 – ); VISNICH, S.; ET AL
A “new” antigen in leukemia sera.
(Order of authorship in the original publication: Blumberg, Alter, Visnich.) Discovery of Australia antigen, hepatitis B antigen, Aa, later called HBsAg. Blumberg received half of the Nobel Prize for Medicine in Biolo…
GMN 3666.4 · https://historyofmedicine.com/id/4823
1967 KRUGMAN, Saul (1911 – 1995); ET AL
Infectious hepatitis. Evidence for two distinctive clinical, epidemiological, and immunological types of infection.
With J. P. Giles and J. Hammond.
GMN 3666.5 · https://historyofmedicine.com/id/4824
1968 BLUMBERG, Baruch Samuel (1925 – 2011); BAYER, Manfred E. (1928 – 2015); WERNER, Barbara G.
Particles associated with Australia antigen in the sera of patients with leukemia, Down's syndrome and hepatitis.
Particles with the appearance of a virus were detected by electron microscopy in the serum of individuals with Au. These were subsequently shown to be the surface antigen particles, different from the whole virus part…
GMN 6840 · https://historyofmedicine.com/id/9004
1969 –1972 BLUMBERG, Baruch Samuel (1925 – 2011); MILLMAN, Irving (1923 – 2012)
Vaccine against viral hepatitis and process. Serial No. 864,788 filed 10 /8 /[19]69. Patent 3636191 issued 1/ 18/ [19]72.
First description of the hepatitis B vaccine, the first cancer vaccine, US patent 3636191A. Millman and Blumberg discovered that the blood of individuals carrying the hepatitis B virus contained particles of the outsi…
GMN 6841 · https://historyofmedicine.com/id/9005
1970 DANE, David Maurice Surrey (1923 – 1998); CAMERON, C. H.; BRIGGS, E. Moya
Virus-like particles in serum of patients with Australia-antigen-associated hepatitis.
(Order of authorship in the original publication: Dane, Cameron, Briggs.) The authors showed that the "Australian antigen" was a virus causing hepatitis B. (Thanks to Juan Weiss for this reference and its interpretati…
GMN 12305 · https://historyofmedicine.com/id/14527
1970 SHERLOCK, Sheila Patricia Violet Dame (1918 – 2001); NIAZI, S. P.; FOX, R. A.
Chronic liver disease and primary liver-cell cancer with hepatitis-associated (Australia) antigen in serum.
(Order of authorship in the original publication: Sherlock, Niazi, Fox...). The authors demonstrated that the hepatitis B virus can cause cancer. (Thanks to Juan Weiss for this reference and its interpretation.)
GMN 12306 · https://historyofmedicine.com/id/14528
1970 BLUMBERG, Baruch Samuel (1925 – 2011); MILLMAN, Irving (1923 – 2012); BAYER, Manfred E. (1928 – 2015); LOEB, Lawrence A.
Australia antigen (a hepatitis-associated antigen). Purification and physical properties.
Purification of the Australia antigen and investigation of its physical properties. (Order of authorship in the original publication: Millman, Loeb, Bayer, Blumberg.) Blumberg shared the 1976 Nobel Prize in Physiology…
GMN 12321 · https://historyofmedicine.com/id/14544
1973 FEINSTONE, Stephen Mark; KAPIKIAN, Albert Zaven (1930 – 2014); PURCELL, Robert Harry (1935 – )
Hepatitis A: Detection by immune electron microscopy of a viruslike antigen associated with acute illness.
Identification of the Hepatitis A virus.
GMN 12652 · https://historyofmedicine.com/id/14895
1989 HOUGHTON, Michael; CHOO, Qui-Lim; KUO, George Ching-Hung; BRADLEY, Daniel W. (1941 – ); OVERBY, Lacy Rasco (1920 – 1994); WEINER, A. J.
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome.
In this paper Houghton and colleagues named “hepatitis C” for the first time. They cloned and isolated the viral RNA genome and demonstrated that a patient who had high antibodies to a ‘native/wild strain’, reacted sp…
GMN 12653 · https://historyofmedicine.com/id/14896
