2013 DOUDNA, Jennifer Anne (1964 – ); JINEK, Martin; CHENG, Aaron; EAST, Alexandra; ET AL
RNA-programmed genome editing in human cells.
Order of authorship in the original publication: Jinek, East, Cheng...Doudna. Doudna and colleagues presented the first demonstration that the CRISPR Cas/Cas9 bacterial editing tool functions could be applied in human…
GMN 11845 · https://historyofmedicine.com/id/14049
2013 CONG, Le; RAN, F. Ann; COX, David; ZHANG, Feng (1981 – ); ET AL
Multiplex genome engineering using CRISPR/Cas systems.
Order of authorship in the original publication: Cong, Ran, Cox....Zhang. Zhang and colleagues edited the genome of human and mouse cells (mammalian cells). Digital facsimile from PubMedCentral at this link. (Thanks t…
GMN 11846 · https://historyofmedicine.com/id/14050
2013 MALI, Prashant; YANG, Luhan; ESVELT, Kevin Michael; CHURCH, George McDonald (1954 – ); ET AL
RNA-guided human genome engineering via Cas9.
Order of authorship in the original publication: Mali, Yang, Esvelt....Church. Church and colleagues reported genome editing in human cells. Digital facsimile from PubMedCentral at this link. (Thanks to Juan Weiss for…
GMN 11847 · https://historyofmedicine.com/id/14051
2014 DOUDNA, Jennifer Anne (1964 – ); CHARPENTIER, Emmanuelle (1968 – )
The new frontier of genome engineering with CRISPR-Cas9.
Order of authorship in the original paper: Doubna, Charpenter. "Abstract "The advent of facile genome engineering using the bacterial RNA-guided CRISPR-Cas9 system in animals and plants is transforming biology. We rev…
GMN 11849 · https://historyofmedicine.com/id/14053
2014 NIU, Yuyu; SHEN, Bin; CUI, Yiqiang; ET AL
Generation of gene-modified Cynomolgus monkey via CAS9/RNA-mediated gene targeting in one-cell embryos.
Order of authorship in the original publication: Niu, Shen, Cui. The authors presented the first evidence that CRISPR can work in primates. Open Archive version available from Cell at this link. "Summary "Monkeys serv…
GMN 11863 · https://historyofmedicine.com/id/14067
2015 WHITWORTH, Kristin Marie; ROWLAND, Raymond R. R.; EWEN, Catherine L.; PRATHER, Randall S.; ET AL
Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus.
Order of authorship in the original publication: Whitworth, Rowland, Ewen, ... Prather. Using the CRISPR Cas molecular gene-editing tool, Prather and colleagues edited the gene that codes for the CD163 protein in adul…
GMN 11848 · https://historyofmedicine.com/id/14052
2015 LIANG, Puping; ZHANG, Xiya; XU, Yanwen; ET AL
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes.
This paper was rejected by both Nature and Science partly for "ethical objections." When published it immediately triggered worldwide controversy among scientists and the public. This was the first application of the …
GMN 11864 · https://historyofmedicine.com/id/14068
2017 GAUDELLI, Nicole M.; KOMOR, Alexis C.; REES, Holly; LIU, David Ruchien (1973 – ); ET AL
Programmable base editing of A-T to G-C.
Order of authorship in the original publication: Gaudelli, Komor, Rees....Liu. Liu and colleagues developed an advanced CRISPR system that can edit pairings of DNA nucleotide bases Adenine and Thymine into Guanine and…
GMN 11865 · https://historyofmedicine.com/id/14069
2019 LIU, David Ruchien (1973 – ); ANZALONE, Andrew V.; RANDOLPH, Peyton B.; DAVIS, Jessie R.; ET AL
Search-and-replace genome editing without double-stranded breaks or donor DNA.
Order of authorship in the original publication: Anzalone, Randolph, Davis....Liu. Liu and colleagues modified the CRISPR tool to create the "prime editing" or precise genome editing technique. Working with human and …
GMN 11866 · https://historyofmedicine.com/id/14070
2020 DOUDNA, Jennifer Anne (1964 – )
The promise and challenge of therapeutic genome editing.
A review of the scope of potential genome editing applications, the strategies from the most basic (2012) to the most recent (i.e. No. 11866), the current status of tissue specific delivery, accuracy, precision and sa…
GMN 11867 · https://historyofmedicine.com/id/14071
2021 FRANGOUL, Haydar A.; ALTSHULER, David Matthew (1964 – ); CAPPELLINI, Maria Domenica; ET AL
CRISPR-Cas9 gene editing for sickle cell disease and ß-thalassemia.
First application of CRISPR gene editing in the successful cure of diseases. Order of authorship in the original publication: Frangoul, Altshuler, Cappellini. (Thanks to Juan Weiss for this reference and its interpret…
GMN 13478 · https://historyofmedicine.com/id/15752
2021 LIU, David Ruchien (1973 – ); COLLINS, Francis Sellers (1950 – ); KOBLAN, Luke W.; ERDOS, Michael R.; WILSON, Christopher; ET AL
In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice.
Using the base editor enzyme developed by Liu (GM11865), the authors report that they can “correct the pathogenic HGPS mutation in cultured fibroblasts derived from children with progeria and in a mouse model of HGPS.…
GMN 14218 · https://historyofmedicine.com/id/16535
