2005 MOJICA, Francisco Juan Martinez (1963 – ); DÍEZ-VILLASEÑOR, César; GARCÍA-MARTÍNEZ, Jesús
Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements.
Order of authorship in the original publication: Mojica, Díez-Villaseñor, Jesus García-Martínez. In this paper Mojica and colleagues showed the the CRISPR system is a bacterial immune system against viral attack. This…
GMN 11842 · https://historyofmedicine.com/id/14046
2007 HORVATH, Philippe (1970 – ); BARRANGOU, Rodolphe; FREMAUX, Christophe; DEVEAU, Hélène
CRISPR provides acquired resistance against viruses in prokaryotes.
Horvath and his team provided key details of the extremely complex mechanisms involved in CRISPR's function as an immune system for bacteria against bacteriophages. Analogous to Pasteur's heroic role in saving the Fre…
GMN 11843 · https://historyofmedicine.com/id/14047
2012 DOUDNA, Jennifer Anne (1964 – ); CHARPENTIER, Emmanuelle (1968 – ); JINEK, Martin; CHYLINSKI, Krzysztof; FONFARA, Ines; HAUER, Michael
A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity.
Order of authorship in the original publication: Jinek, Chylinski, Fonfar, Hauer, Doudna, Charpentier. Doudna, Charpentier and colleagues showed for the first time that the CRISPR evolutionary immune tool of bacteria …
GMN 11844 · https://historyofmedicine.com/id/14048
2015 WHITWORTH, Kristin Marie; ROWLAND, Raymond R. R.; EWEN, Catherine L.; PRATHER, Randall S.; ET AL
Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus.
Order of authorship in the original publication: Whitworth, Rowland, Ewen, ... Prather. Using the CRISPR Cas molecular gene-editing tool, Prather and colleagues edited the gene that codes for the CD163 protein in adul…
GMN 11848 · https://historyofmedicine.com/id/14052
2020 HAMPTON, Hannah G.; WATSON, Bridget N. J.; FINERAN, Peter C.
The arms race between bacteria and their phage foes.
Order of authorship in the original publication: Hampton, Watson, Fineran. Summarizes, and documents with 173 references, the extensive research on the multitude of methods that bacteriophages use to disable the CRISP…
GMN 11868 · https://historyofmedicine.com/id/14072
2020 MENDOZA, Senen D.; NIEWEGLOWSKA, Eliza S.; GOVINDARAJAN, Sutharsan; ET AL
A bacteriophage nucleus like compartment shields DNA from CRISPR nucleases.
Order of authorship in the original publication: Mendoza, Nieweglowska, Govindarajan. The authors showed that the large phage that specifically infects a Pseudomonas bacterium segregates its DNA, which the phage CRISP…
GMN 11876 · https://historyofmedicine.com/id/14080
2020 DOUDNA, Jennifer Anne (1964 – ); AL-SHAYEB, Basem; SACHDEVA, Rohan; CHEN, Lin-Xin; ET AL
Clades of huge phages from across Earth's ecosystems.
Order of authorship in the original publication: Al-Shayeb, Sachdeva, Chen.... Doudna. Open access, available from nature.com at this link. This paper was a collaboration of about 50 scientists of diverse regions and …
GMN 11877 · https://historyofmedicine.com/id/14081
