1978 HUTCHISON, III, Clyde A.; SMITH, Michael (1932 – 2000); ET AL

Mutagenesis at a specific position in a DNA sequence.

Smith and Hutchison introduced site-directed mutagenesis, or oligonucleotide-directed mutagenesis, into molecular biology, resolving the problem of how to determine the effect of a single mutant gene with efficiency. …

GMN 13986 · https://historyofmedicine.com/id/16289