1979 LEVINE, Arnold Jay (1939 – ); LINZER, Daniel I. H. (1954 – )

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40 transformed cells and uninfected embryonal carcinoma cells.

Levine discovered the tumor suppressor protein p53, also known as Tumor protein P53. Because it prevents cancer formation TP 53 is classified as a tumor suppressor gene. The discovery was completed in 1989 and recorde…

GMN 14007 · https://historyofmedicine.com/id/16312

1994 SKOLNICK, Mark Henry (1946 – ); MIKI, Yoshio; SHATTUCK-EIDENS, Donna; ET AL

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

Discovery of the BRCA1 gene using the technique of restriction fragment length polymorphism (RFLP). (Thanks to Juan Weiss for this reference and its interpretation.)

GMN 14015 · https://historyofmedicine.com/id/16322

1994 STRATTON, Sir Michael Rudolf (1957 – ); WOOSTER, Richard; NEUHAUSEN, Susan L.; MANGION, Jonathan; ET AL

Location of a breast cancer susceptibility gene, BRACA2, to chromosome 13q12-13.

Stratton and colleagues discovered the BRCA2 gene. Oder of authorship in the original publication: Wooster, Neuhausen, Mangion....Stratton. (Thanks to Juan Weiss for this reference and its interpretation.)

GMN 14016 · https://historyofmedicine.com/id/16323