1870 WEGNER, Friedrich Rudolph Georg (1843 – 1917)
Ueber hereditäre Knochensyphilis bei jungen Kindern.
“Wegner’s disease” – osteochondritic separation of the epiphyses in congenital syphilis.
GMN 4339 · https://historyofmedicine.com/id/5678
1871 –1872 DUHRING, Louis Adolphus (1845 – 1913); MAURY, Francis Fontaine (1840 – 1879)
Photographic review of medicine and surgery. A bi-monthly illustration of interesting cases, accompanied by notes. Edited by F.F. Maury [and] L.A. Duhring. Vols. 1 & 2 (All published).
The leading 19th century American publication of artistic medical photography. Each of the two volumes includes 24 mounted photographs. The photographs ilustrate cases of unusual and extreme disease, such as gross def…
GMN 10585 · https://historyofmedicine.com/id/12778
1876 WELCH, Francis Henry (1839 – 1910)
On aortic aneurism in the army and the conditions associated with it.
Welch, an Army surgeon, supported the theory of a causal connexion between syphilis and aneurysm.
GMN 2983 · https://historyofmedicine.com/id/5160
1878 –1879 KLEBS, Theodor Albrecht Edwin (1834 – 1913)
Das Contagium der Syphilis. Eine experimentelle Studie.
Klebs inoculated syphilis into apes and probably saw the spirochete before Schaudinn and Hoffmann.
GMN 2392 · https://historyofmedicine.com/id/3325
1886 –1890 MANSUROV, Nikolai Porfir'evich (1834 – 1892)
Klinicheskii sbornik po dermatologii i sifilologii. 4 vols.
Mansurov was the first dermatologist in Russia, and one of the first physicians to use photography systematically in medical illustration. This was a periodical, illustrated with original photographs, of which Manusro…
GMN 7744 · https://historyofmedicine.com/id/9916
1889 BALZER, Félix (1849 – 1929)
Expériences sur la toxicité du bismuth.
Balzer was the first to suggest bismuth in the treatment of syphilis.
GMN 2394 · https://historyofmedicine.com/id/3334
1891 –1895 BURET, Frédéric
Syphilis today and among the ancients. 2 vols.
GMN 2422 · https://historyofmedicine.com/id/2881
1891 CHIARI, Hans (1851 – 1916)
Ueber Magensyphilis.
Important study of gastric syphilis.
GMN 3498 · https://historyofmedicine.com/id/3911
1892 –1896 BRAMWELL, Sir Byrom (1847 – 1931)
Atlas of clinical medicine. 3 vols.
Published at the end of the 19th century, and employing the wide variety of illustration technologies then available, including color lithography, lithography, and photography, this work testifies to the breadth and d…
GMN 10621 · https://historyofmedicine.com/id/12814
1895 JARISCH, Adolf (1850 – 1902)
Therapeutische Versuche bei Syphilis.
Jarisch-Herxheimer reaction; see also No. 2397.
GMN 2396 · https://historyofmedicine.com/id/3343
1895 DÖHLE, Karl Gottfried Paul (1855 – 1928)
Ueber Aortenerkrankung bei Syphilitischen und deren Beziehung zur Aneurysmenbildung.
Döhle clearly defined a specific syphilitic lesion of the aorta as a prerequisite of aortic aneurysm.
GMN 2985.1 · https://historyofmedicine.com/id/5176
1897 FOURNIER, Jean Alfred (1832 – 1915)
Les chancres extra-génitaux.
GMN 2395 · https://historyofmedicine.com/id/3338
1899 HELLER, Arnold Ludwig Gotthilf (1840 – 1913)
Die Aortensyphilis als Ursache von Aneurysmen.
Heller established the fact that syphilis is a cause of aortic aneurysm.
GMN 2987 · https://historyofmedicine.com/id/5184
1901 –1911 BLOCH, Iwan (Ivan) (1872 – 1922)
Der Ursprung der Syphilis. 2 pts.
Bloch was a chief modern supporter of the theory of the Columbian origin of syphilis.
GMN 2423 · https://historyofmedicine.com/id/2882
1902 HERXHEIMER, Karl (1861 – 1944)
Ueber eine bei Syphilitischen vorkommende Quecksilberreaktion.
See No. 2396.
GMN 2397 · https://historyofmedicine.com/id/3344
1903 –1904 METCHNIKOFF, Élie [MECHNIKOV] (1845 – 1916); ROUX, Pierre Paul Émile (1853 – 1933)
Études expérimentales sur la syphilis.
Metchnikoff and Roux successfully transmitted syphilis from man to the higher apes. Although not the first to do this, they recorded much new information concerning the disease.
GMN 2398 · https://historyofmedicine.com/id/3347
1904 CHIARI, Hans (1851 – 1916)
Ueber die syphilitischen Aortenerkrankungen.
GMN 2815 · https://historyofmedicine.com/id/3489
1905 HOFFMANN, Erich (1868 – 1959); SCHAUDINN, Fritz Richard (1871 – 1906)
Vorläufiger Bericht über das Vorkommen von Spirochaeten in syphilitischen Krankheitsprodukten und bei Papillomen.
On March 3, 1905, Schaudinn discovered the causal organism of syphilis Spirochaeta pallida, in serum obtained from a genital lesion by Hoffmann. Schaudinn later renamed the spirochete Treponema pallidum.
GMN 2399 · https://historyofmedicine.com/id/3349
1906 BERTARELLI, Ernesto (1873 – 1957)
Ueber die Transmission der Syphilis auf das Kaninchen. Vorläufiger Bericht.
Transmission of syphilis to rabbits.
GMN 2399.1 · https://historyofmedicine.com/id/3351
1906 LANDSTEINER, Karl (1868 – 1943); MUCHA, Viktor (1877 – 1919)
Zur Technik der Spirochaetenuntersuchung.
Dark field method of diagnosis for presence of T. pallidum.
GMN 2400 · https://historyofmedicine.com/id/3357
1906 LEVADITI, Constantin (1874 – 1953)
A propos de l’impregnation au nitrate d’argent des spirochètes sur coupes.
Levaditi’s method of staining T. pallidum.
GMN 2401 · https://historyofmedicine.com/id/3359
1906 WASSERMANN, August von (1866 – 1925); ET AL
Eine serodiagnostische Reaktion bei Syphilis.
The “Wassermann reaction”, a specific diagnostic blood test for syphilis, and a modification of the complement-fixation reaction of Bordet and Gengou. With A. Neisser and C. Bruck.
GMN 2402 · https://historyofmedicine.com/id/3363
1906 REUTER, Karl
Ueber Spirochaeta pallida in der Aortenwand bei Hellerscher Aortitis.
Treponema pallidum first discovered in the diseased aorta.
GMN 2824 · https://historyofmedicine.com/id/3531
1910 EHRLICH, Paul (1854 – 1915); HATA, Sahachiro (1873 – 1938)
Die experimentelle Chemotherapie der Spirillosen (Syphilis, Rückfallfieber, Hühnerspirillose, Frambösie).
After many experiments on the action of synthetic drugs upon spirochetal diseases, Ehrlich and Hata in 1909 discovered Arsphenamine (Salvarsan, "the arsenic that saves", also known as “606”), an effective treatment fo…
GMN 2403 · https://historyofmedicine.com/id/3366
1911 NOGUCHI, Hideyo (1876 – 1928)
A method for the pure cultivation of pathogenic Treponema pallidum (Spirochaeta pallida).
Pure culture of T. pallidum first obtained. Digital facsimile from digitalcommon.oshu.edu at this link.
GMN 2404 · https://historyofmedicine.com/id/3368
1912 SUDHOFF, Karl Friedrich Jakob (1853 – 1938)
Aus der Frühgeschichte der Syphilis.
Sudhoff believed in the pre-Columbian existence of syphilis.
GMN 2424 · https://historyofmedicine.com/id/2883
1912 EHRLICH, Paul (1854 – 1915)
Ueber Laboratoriumsversuche und klinische Erprobung von Heilstoffen.
Introduction of neoarsphenamine (neosalvarsan).
GMN 2405 · https://historyofmedicine.com/id/3371
1912 SUDHOFF, Karl Friedrich Jakob (1853 – 1938)
Mal Franzoso in Italien in der ersten Hälfte des 15. Jahrhunderts.
Forms Heft 5 of K. Sudhoff & G. Sticker: Zur historischen Biologie der Krankheitserreger.
GMN 2425 · https://historyofmedicine.com/id/3650
1913 LANGE, Karl Friedrich August (1883 – )
Die Ausflockung kolloidalen Goldes durch Zerebrospinalflüssigkeit bei luetischenAffektiondesZentralnervensystems.
Lange’s colloidal gold test for the diagnosis of cerebrospinal syphilis. See also Berl. klin. Wschr., 1912, 49, 897-901.
GMN 2406 · https://historyofmedicine.com/id/3374
1917 MEINICKE, Ernst (1878 – 1945)
Ueber ein neue Methode der serologischen Luesdiagnose.
Meinicke diagnostic reaction.
GMN 2407 · https://historyofmedicine.com/id/3375
1919 SACHS, Hans (1877 – 1945); GEORGI, Walter (1889 – 1920)
Zur Kritik des serologischen Luesnachweises mittels Ausflockung.
Sachs–Georgi diagnostic reaction.
GMN 2408 · https://historyofmedicine.com/id/3378
1919 WEICHARDT, Julius Wolfgang (1875 – 1945); SCHRADER, Erich
Über die Serodiagnostik der Syphilis mittels Ausflockung durch cholesterinierte Extrakte.
Weichardt’s reagent.
GMN 2409 · https://historyofmedicine.com/id/3382
1920 WARTHIN, Aldred Scott (1866 – 1931); STARRY, Allen Chronister (1890 – 1973)
A more rapid and improved method of demonstrating spirochetes in tissues (Warthin and Starry’s cover-glass method).
Warthin and Starry’s method.
GMN 2410 · https://historyofmedicine.com/id/3386
1921 LEVADITI, Constantin (1874 – 1953); SAZERAC, Robert (1875 – )
Traitement de la syphilis par le bismuth.
Introduction of sodium-potassium bismuth tartrate in the treatment of syphilis.
GMN 2411 · https://historyofmedicine.com/id/3390
1922 KAHN, Reuben Leon (1887 – 1979)
A simple quantative precipitation reaction for syphilis.
Kahn test.
GMN 2412 · https://historyofmedicine.com/id/3402
1922 KOLMER, John Albert (1886 – 1962)
Studies in the standardization of the Wassermann reaction. XXX. A new complement-fixation test for syphilis based upon the results of studies in the standardization of technic.
Kolmer test.
GMN 2413 · https://historyofmedicine.com/id/3404
1923 DOHI, Keizo (1866 – 1931)
Beiträge zur Geschichte der Syphilis: insbesondere über ihren Ursprung und ihre Pathologie in Ostasien.
Gives, in an appendix, a list of writers on syphilis from 1495 to 1829. Digital facsimile from wellcomecollection.org at this link.
GMN 2426 · https://historyofmedicine.com/id/2884
1925 SUDHOFF, Karl Friedrich Jakob (1853 – 1938); SINGER, Charles Joseph (1876 – 1960)
The earliest printed literature on syphilis. Being ten tractates from the years 1495-98
GMN 2427 · https://historyofmedicine.com/id/2886
1926 LOEVENHART, Arthur Salomon (1878 – 1929); STRATMAN-THOMAS, Warren Kidwell (1894 – 1946)
On the chemotherapy of neurosyphilis and trypanosomiasis.
Study of the effect of twelve different substances in neurosyphilis and trypanosomiasis.
GMN 1915 · https://historyofmedicine.com/id/2682
1927 STOKES, John Hinchman (1885 – 1961); CHAMBERS, Stanley Owen (1897 – )
Bismuth arsphenamine sulphate.
Clinical introduction of bismarsen, synthesized by G. W. Raiziss in 1924.
GMN 2414 · https://historyofmedicine.com/id/3407
1931 JEANSELME, Antoine Edouard (1858 – 1935)
Histoire de la syphilis.
Forms tome I of Traité de la syphilis, ed. by E. Jeanselme and E. Shulmann.
GMN 2428 · https://historyofmedicine.com/id/2885
1932 EAGLE, Harry (1905 – 1992)
Studies in the serology of syphilis. VII. A new flocculation test for the serum diagnosis of syphilis.
Eagle flocculation test.
GMN 2414.1 · https://historyofmedicine.com/id/3409
1933 PUSEY, William Allen (1865 – 1940)
The history and epidemiology of syphilis.
GMN 2429 · https://historyofmedicine.com/id/3651
1934 TATUM, Arthur Lawrie (1884 – 1955); COOPER, Garrett Arthur (1904 – )
An experimental study of mapharsen (meta-amino para-hydroxy phenyl arsine oxide) as an antisyphilitic agent.
Introduction of mapharsen.
GMN 2415 · https://historyofmedicine.com/id/3412
1935 FLECK, Ludwik (1896 – 1961)
Entstehung und Entwicklung einer wissenschaftlichen Tatsache. Einführung in die Lehre vom Denkstil und Denkkollektiv.
A very thorough history of the discovery of the Wasserman reaction, and its acceptance by the scientific community. English translation: Genesis and development of a scientific fact, Chicago, Univ. of Chicago Press, 1…
GMN 2429.1 · https://historyofmedicine.com/id/2887
1935 FOERSTER, Otto Hottinger (1876 – 1965); ET AL
Mapharsen in the treatment of syphilis. A preliminary report.
Clinical use of mapharsen. With R. L. McIntosh, L. M. Wieder, H. R. Foerster, and G. A. Cooper.
GMN 2416 · https://historyofmedicine.com/id/3416
1937 HOLCOMBE, Richmond Cranston (1874 – 1945)
Who gave the world syphilis? The Haitian myth.
GMN 2430 · https://historyofmedicine.com/id/2888
1940 WHITWELL, James Richard (1863 – 1945)
Syphilis in earlier days.
GMN 2431 · https://historyofmedicine.com/id/2889
1941 PANGBORN, Mary Candace (1907 – 2003)
A new serologically active phospholipid from beef heart.
Cardiolipin antigen for serological diagnosis of syphilis. For isolation and purification see J. biol. Chem., 1942, 143, 247-56.
GMN 2417 · https://historyofmedicine.com/id/3420
1943 MAHONEY, John Friend (1889 – 1957); ARNOLD, Richard C. (1906 – 1992); HARRIS, Ad
Penicillin treatment of early syphilis. A preliminary report.
Mahoney and colleagues introduced penicillin in treatment of syphilis. This was the report of the first four cases of patients with early stages of the disease. Digital facsimile of the version published in the the Am…
GMN 2418 · https://historyofmedicine.com/id/3422
