1805 SERTÜRNER, Friedrich Wilhelm Adam (1783 – 1841)

Darstellung der reinen Mohnsäure (Opiumsäure); nebst einer chemischen Untersuchung des Opiums, mit vorzüglicher Hinsicht auf einen darin neu entdeckten Stoff.

Isolation of morphine from opium. This was the first isolation of an active ingredient from a plant.

GMN 1839 · https://historyofmedicine.com/id/2269

1874 WRIGHT, Charles Romley Alder (1844 – 1894)

On the action of organic acids and their anydrides on the natural alkaloïds. Part I.

In quest of a non-addictive alternative to morphine, Wright experimented with combining morphine with various acids. He boiled anhydrous morphine alkaloid with acetic anhydride over a stove for several hours and produ…

GMN 11087 · https://historyofmedicine.com/id/13283

1926 GOTTLIEB, Rudolf (1864 – 1924)

Vergleichende Messungen über die Gewöhnung des Atemzentrums an Morphin, Dicodid und Dilaudid.

Introduction of dilaudid (Hydromorphone)

GMN 1913 · https://historyofmedicine.com/id/2678

1939 EISLER, O; SCHAUMANN, O

Dolantin, ein neuartiges Spasmolytikum und Analgetikum. (Chemisches und pharmakologisches.)

Synthesis of pethidine (dolantin) (Demoral).

GMN 1927 · https://historyofmedicine.com/id/2723

2002 MUSTO, David Franklin (1936 – 2010); KORSMEYER, Pamela (1945 – ); MAULUCCI, Thomas W. Jr.

One hundred years of heroin. Edited by David F. Musto with the assistance of Pamela Korsmeyer and Thomas W. Maulucci, Jr.

GMN 12416 · https://historyofmedicine.com/id/14646